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UniProtKB/Swiss-Prot entry P27112

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATP4A_RABIT
Primary accession number P27112
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 74)
Name and origin of the protein
Protein name Potassium-transporting ATPase alpha chain 1
Synonyms EC 3.6.3.10
Proton pump
Gastric H(+)/K(+) ATPase subunit alpha
Gene name
Name: ATP4A
From
Oryctolagus cuniculus (Rabbit) [TaxID: 9986] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white;
DOI=10.1016/0167-4781(92)90100-E; PubMed=1316171 [NCBI, ExPASy, EBI, Israel, Japan]
Bamberg K., Mercier F., Reuben M.A., Kobayashi Y., Munson K.B., Sachs G.;
"cDNA cloning and membrane topology of the rabbit gastric H+/K(+)-ATPase alpha-subunit.";
Biochim. Biophys. Acta 1131:69-77(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X64694; CAA45927.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S23406; S23406.
RefSeq NP_001095171.1; -.
UniGene Ocu.3252
3D structure databases
HSSP P19156; 1IWC. [HSSP ENTRY / PDB]
ModBase P27112.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008900; Molecular function: hydrogen:potassium-exchanging ATPase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
GO:0006813; Biological process: potassium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006069; ATPase_cat_a.
IPR005775; ATPase_cat_a_euk.
IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR015127; H-K_ATPase_N.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF09040; H-K_ATPase_N; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00121; NAKATPASE.
TIGRFAMs TIGR01106; ATPase-IIC_X-K; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
BLOCKS P27112.
ProtoNet P27112.
Genome annotation databases
GeneID 100009279; -.
Phylogenomic databases
HOVERGEN P27112; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Hydrogen ion transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Potassium; Potassium transport; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
INIT_MET   1      1        Removed (By similarity). 
CHAIN   2   1035  1034     Potassium-transporting ATPase alpha chain 1. PRO_0000046256
TOPO_DOM   2     98  97     Cytoplasmic (Potential). 
TRANSMEM   99    119  21     Potential. 
TOPO_DOM   120    142  23     Lumenal (Potential). 
TRANSMEM   143    163  21     Potential. 
TOPO_DOM   164    299  136     Cytoplasmic (Potential). 
TRANSMEM   300    319  20     Potential. 
TOPO_DOM   320    331  12     Lumenal (Potential). 
TRANSMEM   332    349  18     Potential. 
TOPO_DOM   350    783  434     Cytoplasmic (Potential). 
TRANSMEM   784    803  20     Potential. 
TOPO_DOM   804    813  10     Lumenal (Potential). 
TRANSMEM   814    834  21     Potential. 
TOPO_DOM   835    854  20     Cytoplasmic (Potential). 
TRANSMEM   855    877  23     Potential. 
TOPO_DOM   878    929  52     Lumenal (Potential). 
TRANSMEM   930    949  20     Potential. 
TOPO_DOM   950    963  14     Cytoplasmic (Potential). 
TRANSMEM   964    982  19     Potential. 
TOPO_DOM   983    997  15     Lumenal (Potential). 
TRANSMEM   998   1018  21     Potential. 
TOPO_DOM   1019   1035  17     Cytoplasmic (Potential). 
ACT_SITE   387    387        4-aspartylphosphate intermediate (By similarity). 
METAL   728    728        Magnesium (By similarity). 
METAL   732    732        Magnesium (By similarity). 
MOD_RES   954    954        Phosphoserine; by PKA (By similarity). 
Sequence information
Length: 1035 AA [This is the length of the unprocessed precursor] Molecular weight: 114202 Da [This is the MW of the unprocessed precursor] CRC64: FCD600AC142CC14A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGKADNYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA 

        70         80         90        100        110        120 
ELEQKYQTSA TKGLSARLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA 

       130        140        150        160        170        180 
ICLIAFAIQA SEGDLTTDDN LYLALALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA 

       190        200        210        220        230        240 
TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP 

       250        260        270        280        290        300 
ECTHESPLET RNIAFFSTMC LEGTAQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE 

       310        320        330        340        350        360 
HFVDIIAGLA ILFGATFFVV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK 

       370        380        390        400        410        420 
RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ 

       430        440        450        460        470        480 
TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG 

       490        500        510        520        530        540 
YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP 

       550        560        570        580        590        600 
LDEQWREAFQ TAYLSLGGLG ERVLGFCHLY LSEKDYPPGY AFDVEAMNFP SSGLCFAGLV 

       610        620        630        640        650        660 
SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR 

       670        680        690        700        710        720 
VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG 

       730        740        750        760        770        780 
AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF 

       790        800        810        820        830        840 
DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES 

       850        860        870        880        890        900 
DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRPQ 

       910        920        930        940        950        960 
WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT RRLSAFQQGF 

       970        980        990       1000       1010       1020 
FRNRILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPMPFGLLI FVYDEIRKLG 

      1030 
VRCCPGSWWD QELYY
P27112 in FASTA format

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