|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1849653 [NCBI, ExPASy, EBI, Israel, Japan]
Bradbury A.,
Possenti R.,
Shooter E.M.,
Tirone F.;
"Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.";
Proc. Natl. Acad. Sci. U.S.A. 88:3353-3357(1991).
|
[2]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[3]
|
CHARACTERIZATION.
DOI=10.1016/0925-4773(94)90085-X; PubMed=7811636 [NCBI, ExPASy, EBI, Israel, Japan]
Iacopetti P.,
Barsacchi G.,
Tirone F.,
Maffei L.,
Cremisi F.;
"Developmental expression of PC3 gene is correlated with neuronal cell birthday.";
Mech. Dev. 47:127-137(1994).
|
[4]
|
CHARACTERIZATION.
PubMed=8891336 [NCBI, ExPASy, EBI, Israel, Japan]
Montagnoli A.,
Guardavaccaro D.,
Starace G.,
Tirone F.;
"Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition.";
Cell Growth Differ. 7:1327-1336(1996).
|
[5]
|
INTERACTION WITH PRKCABP.
DOI=10.1042/0264-6021:3540635; PubMed=11237868 [NCBI, ExPASy, EBI, Israel, Japan]
Lin W.-J.,
Chang Y.-F.,
Wang W.-L.,
Huang C.-Y.F.;
"Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1.";
Biochem. J. 354:635-643(2001).
|
|
|
|
- FUNCTION: Modulates transcription regulation mediated by ESR1 (By similarity). Anti-proliferative protein. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors.
- SUBUNIT: Binds the CCR4-NOT complex (By similarity). Interacts with PRKCABP.
- INTERACTION:
Q9EP80:Pick1; NbExp=2; IntAct=EBI-78953, EBI-77728;
- TISSUE SPECIFICITY: In brain at embryonic day 13.5, placenta, amnion, and spleen, which are proliferating and/or differentiating.
- INDUCTION: By nerve growth factor. At lower levels by epidermal growth factor and membrane depolarization. At much lower levels by fibroblast growth factor and interleukin 6.
- SIMILARITY: Belongs to the BTG family.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 158 AA [This is the length of the unprocessed precursor] |
Molecular weight: 17728 Da [This is the MW of the unprocessed precursor] |
CRC64: F9105D73C3CDF24A [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MSHGKRTDML PEIAAAVGFL TSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS
70 80 90 100 110 120
KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHQLLPSEL TLWVDPYEVS YRIGEDGSIC
130 140 150
VLYEEAPVAT SYGLLTCKNQ MMLGRSSPSK NYVMTVSS
|
P27049 in FASTA format |
|
ExPASy Home page
APAF Australia