NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1016/0167-4781(91)90118-6; PubMed=1932124 [NCBI, ExPASy, EBI, Israel, Japan]
Nakano T., Graf T.;
"Goose-type lysozyme gene of the chicken: sequence, genomic organization and expression reveals major differences to chicken-type lysozyme gene.";
Biochim. Biophys. Acta 1090:273-276(1991).

Comments

CATALYTIC ACTIVITY: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Granulocyte compartment of myelomonocytic cells.
MISCELLANEOUS: Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.
SIMILARITY: Belongs to the glycosyl hydrolase 23 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X61001; CAA43319.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X61002; CAA43320.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X61197; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]
X61198; CAB37929.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S18463; S18463.

NP_001001470.1; -.

3D structure databases

HSSP

P00717; 1GBS. [HSSP ENTRY / PDB]

SMR

P27042; 28-211.

ModBase

P27042.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0003796;	Molecular function: lysozyme activity (inferred from electronic annotation from InterPro).
GO:0016998;	Biological process: cell wall catabolic process (inferred from electronic annotation from InterPro).
GO:0019835;	Biological process: cytolysis (inferred from electronic annotation from UniProtKB-KW).
GO:0042742;	Biological process: defense response to bacterium (inferred from electronic annotation from UniProtKB-KW).
GO:0009253;	Biological process: peptidoglycan catabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR002152; Glyco_hydro_23.
IPR008258; Lytic_TGlycosylase-like_cat.
Graphical view of domain structure.

Pfam

PF01464; SLT; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001065; Lysozyme_g; 1.

PR00749; LYSOZYMEG.

Genome annotation databases

Ensembl

ENSGALG00000016761; Gallus gallus. [Contig view]

GeneID

395708; -.

KEGG

gga:395708; -.

Phylogenomic databases

HOGENOM

P27042; -.

HOVERGEN

P27042; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antimicrobial; Bacteriolytic enzyme; Glycosidase; Hydrolase; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 26`	`26`	`Potential.`
`CHAIN`	`27 211`	`185`	`Lysozyme g.`	`PRO_0000012022`
`ACT_SITE`	`99 99`		`By similarity.`
`ACT_SITE`	`112 112`		`By similarity.`
`DISULFID`	`30 86`		`By similarity.`
`DISULFID`	`44 55`		`By similarity.`

Sequence information

Length: 211 AA [This is the length of the unprocessed precursor]

Molecular weight: 23238 Da [This is the MW of the unprocessed precursor]

CRC64: 8ECBE38AC9F67A9E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLGKNDPMCL VLVLLGLTAL LGICQGGTGC YGSVSRIDTT GASCRTAKPE GLSYCGVRAS 

        70         80         90        100        110        120 
RTIAERDLGS MNKYKVLIKR VGEALCIEPA VIAGIISRES HAGKILKNGW GDRGNGFGLM 

       130        140        150        160        170        180 
QVDKRYHKIE GTWNGEAHIR QGTRILIDMV KKIQRKFPRW TRDQQLKGGI SAYNAGVGNV 

       190        200        210 
RSYERMDIGT LHDDYSNDVV ARAQYFKQHG Y

P27042 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools