ID   AVR2B_XENLA             Reviewed;         511 AA.
AC   P27041;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-NOV-2008, entry version 68.
DE   RecName: Full=Activin receptor type-2B;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor type IIB;
DE            Short=ACTR-IIB;
DE   Flags: Precursor;
GN   Name=acvr2b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92205349; PubMed=1313188;
RA   Mathews L.S., Vale W.W., Kintner C.R.;
RT   "Cloning of a second type of activin receptor and functional
RT   characterization in Xenopus embryos.";
RL   Science 255:1702-1705(1992).
CC   -!- FUNCTION: Receptor for activin A, activin B and inhibin A.
CC       Involved in transmembrane signaling.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; M88594; AAB00480.1; -; mRNA.
DR   RefSeq; NP_001084049.1; -.
DR   UniGene; Xl.1053; -.
DR   HSSP; P27038; 1BTE.
DR   SMR; P27041; 26-119.
DR   GeneID; 399277; -.
DR   KEGG; xla:399277; -.
DR   Xenbase; XB-FEAT-484247; acvr2b.
DR   HOVERGEN; P27041; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017002; F:activin receptor activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0032924; P:activin receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR015768; Activin_II_recpt_C.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF10; Activin_II_recpt_C; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding;
KW   Receptor; Serine/threonine-protein kinase; Signal; Transferase;
KW   Transmembrane.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    511       Activin receptor type-2B.
FT                                /FTId=PRO_0000024407.
FT   TOPO_DOM     21    136       Extracellular (Potential).
FT   TRANSMEM    137    157       Potential.
FT   TOPO_DOM    158    511       Cytoplasmic (Potential).
FT   DOMAIN      189    477       Protein kinase.
FT   NP_BIND     195    203       ATP (By similarity).
FT   ACT_SITE    320    320       Proton acceptor (By similarity).
FT   BINDING     216    216       ATP (By similarity).
FT   CARBOHYD     43     43       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     67     67       N-linked (GlcNAc...) (Potential).
FT   DISULFID     30     61       By similarity.
FT   DISULFID     86    105       By similarity.
FT   DISULFID     92    104       By similarity.
FT   DISULFID    106    111       By similarity.
SQ   SEQUENCE   511 AA;  57936 MW;  A87F1E6BC78C92F0 CRC64;
     MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL VEGKKDKRLH
     CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ VFFCCCEGNY CNKKFTHLPE
     VETFDPKPQP SASVLNILIY SLLPIVGLSM AILLAFWMYR HRKPSYGHVE INEDPGLPPP
     SPLVGLKPLQ LLDIKARGRF GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH
     ENLLEFIAAE KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL
     HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP PGDTHGQVGT
     RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT AADGPVDEYL LPFEEEIGQH
     PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI
     RKSVNGTTSD CLVSIVTSVT NVDLPPKESS I
//