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UniProtKB/Swiss-Prot entry P27041

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AVR2B_XENLA
Primary accession number P27041
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 65)
Name and origin of the protein
Protein name Activin receptor type-2B [Precursor]
Synonyms EC 2.7.11.30
Activin receptor type IIB
ACTR-IIB
Gene name
Name: acvr2b
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1313188 [NCBI, ExPASy, EBI, Israel, Japan]
Mathews L.S., Vale W.W., Kintner C.R.;
"Cloning of a second type of activin receptor and functional characterization in Xenopus embryos.";
Science 255:1702-1705(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M88594; AAB00480.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001084049.1; -.
UniGene Xl.1053
3D structure databases
HSSP P27038; 1BTE. [HSSP ENTRY / PDB]
SMR P27041; 26-119.
ModBase P27041.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
PANTHER PTHR23255:SF10; Activin_II_recpt_C; 1.
Pfam PF01064; Activin_recp; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P27041.
Genome annotation databases
GeneID 399277; -.
KEGG xla:399277; -.
Phylogenomic databases
HOVERGEN P27041; -.
Other
ProtoNet P27041.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   511  491     Activin receptor type-2B. PRO_0000024407
TOPO_DOM   21   136  116     Extracellular (Potential). 
TRANSMEM   137   157  21     Potential. 
TOPO_DOM   158   511  354     Cytoplasmic (Potential). 
DOMAIN   189   477  289     Protein kinase. 
NP_BIND   195   203  9     ATP (By similarity). 
ACT_SITE   320   320        Proton acceptor (By similarity). 
BINDING   216   216        ATP (By similarity). 
CARBOHYD   43    43        N-linked (GlcNAc...) (Potential). 
CARBOHYD   67    67        N-linked (GlcNAc...) (Potential). 
DISULFID   30    61        By similarity. 
DISULFID   86   105        By similarity. 
DISULFID   92   104        By similarity. 
DISULFID   106   111        By similarity. 
Sequence information
Length: 511 AA [This is the length of the unprocessed precursor] Molecular weight: 57936 Da [This is the MW of the unprocessed precursor] CRC64: A87F1E6BC78C92F0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGASVALTFL LLLATFRAGS GHDEVETREC IYYNANWELE KTNQSGVERL VEGKKDKRLH 

        70         80         90        100        110        120 
CYASWRNNSG FIELVKKGCW LDDFNCYDRQ ECIAKEENPQ VFFCCCEGNY CNKKFTHLPE 

       130        140        150        160        170        180 
VETFDPKPQP SASVLNILIY SLLPIVGLSM AILLAFWMYR HRKPSYGHVE INEDPGLPPP 

       190        200        210        220        230        240 
SPLVGLKPLQ LLDIKARGRF GCVWKARLLN EYVAVKIFPV QDKQSWQCEK EIFTTPGMKH 

       250        260        270        280        290        300 
ENLLEFIAAE KRGSNLEMEL WLITAFHDKG SLTDYLKGNL VSWNELCHIT ETMARGLAYL 

       310        320        330        340        350        360 
HEDVPRCKGE GHKPAIAHRD FKSKNVLLRN DLTAILADFG LAVRFEPGKP PGDTHGQVGT 

       370        380        390        400        410        420 
RRYMAPEVLE GAINFQRDSF LRIDMYAMGL VLWEIVSRCT AADGPVDEYL LPFEEEIGQH 

       430        440        450        460        470        480 
PSLEDLQEVV VHKKIRPVFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI 

       490        500        510 
RKSVNGTTSD CLVSIVTSVT NVDLPPKESS I
P27041 in FASTA format

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