NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ACTR-IIB1; ACTR-IIB2; ACTR-IIB3 AND ACTR-IIB4).
STRAIN=BALB/c;
DOI=10.1016/0092-8674(92)90209-U; PubMed=1310075 [NCBI, ExPASy, EBI, Israel, Japan]
Attisano L., Wrana J.L., Cheifetz S., Massague J.;
"Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors.";
Cell 68:97-108(1992).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing. ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4.

Name	ActR-IIB1
Isoform ID	P27040-1
This is the isoform sequence displayed in this entry.

Name	ActR-IIB2
Isoform ID	P27040-2
Features which should be applied to build the isoform sequence: VSP_004952.

Name	ActR-IIB3
Isoform ID	P27040-3
Features which should be applied to build the isoform sequence: VSP_004951.

Name	ActR-IIB4
Isoform ID	P27040-4
Features which should be applied to build the isoform sequence: VSP_004951, VSP_004952.

SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M84120; AAA37172.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A40829; A40829.
B40829; B40829.
C40829; C40829.
D40829; D40829.

RefSeq

NP_031423.1; -.

UniGene

Mm.390239

3D structure databases

PDB

1S4Y; X-ray; 2.30 A; A/C=23-120.	[ExPASy / RCSB / EBI]
2H64; X-ray; 1.92 A; C=19-117.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1S4Y; -.
2H64; -.

ModBase

P27040.

Protein-protein interaction databases

DIP

DIP:5799N; -.

PTM databases

PhosphoSite

P27040; -.

Organism-specific databases

MGI

MGI:87912; Acvr2b.

GeneLynx

Acvr2b; Mus musculus.

Gene expression databases

ArrayExpress

P27040; -.

CleanEx

MM_ACVR2B; -.

GermOnline

ENSMUSG00000061393; Mus musculus.

Ontologies

GO:0048185;	Molecular function: activin binding (inferred from direct assay from MGI).
GO:0019838;	Molecular function: growth factor binding (inferred from mutant phenotype from MGI).
GO:0004674;	Molecular function: protein serine/threonine kinase activity (inferred from direct assay from MGI).
GO:0004712;	Molecular function: protein serine/threonine/tyrosine kinase activity (inferred from direct assay from MGI).
GO:0032147;	Biological process: activation of protein kinase activity (inferred from direct assay from MGI).
GO:0009952;	Biological process: anterior/posterior pattern formation (inferred from mutant phenotype from MGI).
GO:0007368;	Biological process: determination of left/right symmetry (inferred from mutant phenotype from MGI).
GO:0048617;	Biological process: embryonic foregut morphogenesis (inferred from mutant phenotype from MGI).
GO:0001702;	Biological process: gastrulation with mouth forming second (inferred from genetic interaction from MGI).
GO:0007507;	Biological process: heart development (inferred from mutant phenotype from MGI).
GO:0030073;	Biological process: insulin secretion (inferred from genetic interaction from MGI).
GO:0001822;	Biological process: kidney development (inferred from genetic interaction from MGI).
GO:0030324;	Biological process: lung development (inferred from genetic interaction from MGI).
GO:0007498;	Biological process: mesoderm development (inferred from genetic interaction from MGI).
GO:0042475;	Biological process: odontogenesis of dentine-containing tooth (inferred from mutant phenotype from MGI).
GO:0035265;	Biological process: organ growth (inferred from genetic interaction from MGI).
GO:0060021;	Biological process: palate development (inferred from genetic interaction from MGI).
GO:0031016;	Biological process: pancreas development (inferred from genetic interaction from MGI).
GO:0009791;	Biological process: post-embryonic development (inferred from genetic interaction from MGI).
GO:0009749;	Biological process: response to glucose stimulus (inferred from genetic interaction from MGI).
GO:0048705;	Biological process: skeletal morphogenesis (inferred from mutant phenotype from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF10; Activin_II_recpt_C; 1.

Pfam

PF01064; Activin_recp; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P27040.

Genome annotation databases

Ensembl

ENSMUSG00000061393; Mus musculus. [Contig view]

GeneID

11481; -.

KEGG

mmu:11481; -.

Phylogenomic databases

HOGENOM

P27040; -.

HOVERGEN

P27040; -.

Other

SOURCE

Acvr2b; Mus musculus.

ProtoNet

P27040.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`CHAIN`	`19 536`	`518`	`Activin receptor type-2B.`	`PRO_0000024405`
`TOPO_DOM`	`19 137`	`119`	`Extracellular (Potential).`
`TRANSMEM`	`138 158`	`21`	`Potential.`
`TOPO_DOM`	`159 536`	`378`	`Cytoplasmic (Potential).`
`DOMAIN`	`214 504`	`291`	`Protein kinase.`
`NP_BIND`	`220 228`	`9`	`ATP (By similarity).`
`ACT_SITE`	`345 345`		`Proton acceptor (By similarity).`
`BINDING`	`241 241`		`ATP (By similarity).`
`CARBOHYD`	`42 42`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`65 65`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`29 59`
`DISULFID`	`49 77`
`DISULFID`	`84 103`
`DISULFID`	`90 102`
`DISULFID`	`104 109`
`VAR_SEQ`	`124 131`		`Missing (in isoform ActR-IIB3 and isoform ActR-IIB4).`	`VSP_004951`
`VAR_SEQ`	`175 198`		`Missing (in isoform ActR-IIB2 and isoform ActR-IIB4).`	`VSP_004952`
`STRAND`	`28 33`	`6`
`HELIX`	`36 39`	`4`
`STRAND`	`43 48`	`6`
`STRAND`	`57 66`	`10`
`STRAND`	`69 79`	`11`
`HELIX`	`82 84`	`3`
`STRAND`	`93 96`	`4`
`STRAND`	`98 106`	`9`
`TURN`	`107 110`	`4`

Sequence information

Length: 536 AA [This is the length of the unprocessed precursor]

Molecular weight: 60542 Da [This is the MW of the unprocessed precursor]

CRC64: BF1C8CAC974BF5E2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 

        70         80         90        100        110        120 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 

       130        140        150        160        170        180 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEVRQCQR 

       190        200        210        220        230        240 
WAGRRDGCAD SFKPLPFQDP GPPPPSPLVG LKPLQLLEIK ARGRFGCVWK AQLMNDFVAV 

       250        260        270        280        290        300 
KIFPLQDKQS WQSEREIFST PGMKHENLLQ FIAAEKRGSN LEVELWLITA FHDKGSLTDY 

       310        320        330        340        350        360 
LKGNIITWNE LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN VLLKSDLTAV 

       370        380        390        400        410        420 
LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF QRDAFLRIDM YAMGLVLWEL 

       430        440        450        460        470        480 
VSRCKAADGP VDEYMLPFEE EIGQHPSLEE LQEVVVHKKM RPTIKDHWLK HPGLAQLCVT 

       490        500        510        520        530 
IEECWDHDAE ARLSAGCVEE RVSLIRRSVN GTTSDCLVSL VTSVTNVDLL PKESSI

P27040 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools