ID   AVR2A_XENLA             Reviewed;         514 AA.
AC   P27039; Q5D043;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-NOV-2008, entry version 70.
DE   RecName: Full=Activin receptor type-2A;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor type IIA;
DE            Short=ACTR-IIA;
DE   Flags: Precursor;
GN   Name=acvr2a; Synonyms=acvr2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92095974; PubMed=1661587; DOI=10.1016/0006-291X(91)91245-8;
RA   Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R.,
RA   Muramatsu M., Shiokawa K.;
RT   "Activin receptor mRNA is expressed early in Xenopus embryogenesis and
RT   the level of the expression affects the body axis formation.";
RL   Biochem. Biophys. Res. Commun. 181:684-690(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for activin A, activin B and inhibin A.
CC       Involved in transmembrane signaling.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; S70930; AAB20638.1; -; mRNA.
DR   EMBL; BC066770; AAH66770.1; -; mRNA.
DR   PIR; JQ1317; JQ1317.
DR   RefSeq; NP_001084061.1; -.
DR   UniGene; Xl.1080; -.
DR   HSSP; P27038; 1BTE.
DR   SMR; P27039; 27-120.
DR   GeneID; 399283; -.
DR   KEGG; xla:399283; -.
DR   Xenbase; XB-FEAT-484011; acvr2a.
DR   HOVERGEN; P27039; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017002; F:activin receptor activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0032924; P:activin receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR015768; Activin_II_recpt_C.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   PANTHER; PTHR23255:SF10; Activin_II_recpt_C; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding;
KW   Receptor; Serine/threonine-protein kinase; Signal; Transferase;
KW   Transmembrane.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    514       Activin receptor type-2A.
FT                                /FTId=PRO_0000024402.
FT   TOPO_DOM     21    136       Extracellular (Potential).
FT   TRANSMEM    137    162       Potential.
FT   TOPO_DOM    163    514       Cytoplasmic (Potential).
FT   DOMAIN      193    486       Protein kinase.
FT   NP_BIND     199    207       ATP (By similarity).
FT   ACT_SITE    323    323       Proton acceptor (By similarity).
FT   BINDING     220    220       ATP (By similarity).
FT   CARBOHYD     46     46       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     67     67       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     88     88       N-linked (GlcNAc...) (Potential).
FT   DISULFID     31     61       By similarity.
FT   DISULFID     51     79       By similarity.
FT   DISULFID     86    105       By similarity.
FT   DISULFID     92    104       By similarity.
FT   DISULFID    106    111       By similarity.
SQ   SEQUENCE   514 AA;  57904 MW;  9FA4B4D7F9756C26 CRC64;
     MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI CYGDNDKRKH
     CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD VFFCCCEGNY CNEKFYHSPE
     MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG
     PPPPSPLLGL KPLQLLEVKA RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP
     GMKHENILYF IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG
     LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA GKSAGDTHGQ
     VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS RCTASDGPVD EYMLPFEEEV
     GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA GMAMLCETIE ECWDHDAEAR LSAGCVEERI
     IQMQKLTNII TTEDIVTVVT MVTNVDFPPK ESSL
//