[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0006-291X(91)91245-8; PubMed=1661587 [NCBI, ExPASy, EBI, Israel, Japan] Kondo M., Tashiro K., Fujii G., Asano M., Miyoshi R., Yamada R., Muramatsu M., Shiokawa K.; "Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation."; Biochem. Biophys. Res. Commun. 181:684-690(1991).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S70930; AAB20638.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066770; AAH66770.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JQ1317; JQ1317.

NP_001084061.1; -.

3D structure databases

HSSP

P27038; 1BTE. [HSSP ENTRY / PDB]

SMR

P27039; 27-120.

ModBase

P27039.

Family and domain databases

InterPro

IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF10; Activin_II_recpt_C; 1.

Pfam

PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00653; ACTIVIN2R.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P27039.

Genome annotation databases

GeneID

399283; -.

KEGG

xla:399283; -.

Phylogenomic databases

HOVERGEN

P27039; -.

Other

ProtoNet

P27039.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`CHAIN`	`21 514`	`494`	`Activin receptor type-2A.`	`PRO_0000024402`
`TOPO_DOM`	`21 136`	`116`	`Extracellular (Potential).`
`TRANSMEM`	`137 162`	`26`	`Potential.`
`TOPO_DOM`	`163 514`	`352`	`Cytoplasmic (Potential).`
`DOMAIN`	`193 486`	`294`	`Protein kinase.`
`NP_BIND`	`199 207`	`9`	`ATP (By similarity).`
`ACT_SITE`	`323 323`		`Proton acceptor (By similarity).`
`BINDING`	`220 220`		`ATP (By similarity).`
`CARBOHYD`	`46 46`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`67 67`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`88 88`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`31 61`		`By similarity.`
`DISULFID`	`51 79`		`By similarity.`
`DISULFID`	`86 105`		`By similarity.`
`DISULFID`	`92 104`		`By similarity.`
`DISULFID`	`106 111`		`By similarity.`

Sequence information

Length: 514 AA [This is the length of the unprocessed precursor]

Molecular weight: 57904 Da [This is the MW of the unprocessed precursor]

CRC64: 9FA4B4D7F9756C26 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGAATKLAFA VFLISCSSAG SILGRSETKE CIYYNANWEK DKTNSNGTEI CYGDNDKRKH 

        70         80         90        100        110        120 
CFATWKNISG SIEIVKQGCW LDDINCYNKS KCTEKKDSPD VFFCCCEGNY CNEKFYHSPE 

       130        140        150        160        170        180 
MEVTQPTSNP VTTKPPLFNT LLYSLVPIMV VAVIVLFSFW MYRHHKLAYP PVLVPTQDPG 

       190        200        210        220        230        240 
PPPPSPLLGL KPLQLLEVKA RGRFGCVWKA QLLNETVAVK IFPVQDKLSW QNEYEIYSLP 

       250        260        270        280        290        300 
GMKHENILYF IGAEKRGTNL DTDLWLITAF HEKGSLTDYL KANVVSWNEL CLIAETMARG 

       310        320        330        340        350        360 
LSHLHEDIPG LKDGHKPAVA HRDIKSKNVL LKNNLTACIA DFGLALKFEA GKSAGDTHGQ 

       370        380        390        400        410        420 
VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELAS RCTASDGPVD EYMLPFEEEV 

       430        440        450        460        470        480 
GQHPSLEDMQ EVVVHKKKRP ILRECWQKHA GMAMLCETIE ECWDHDAEAR LSAGCVEERI 

       490        500        510 
IQMQKLTNII TTEDIVTVVT MVTNVDFPPK ESSL

P27039 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools