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UniProtKB/Swiss-Prot entry P27037


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AVR2A_HUMAN
Primary accession number P27037
Secondary accession numbers Q53TH4 Q6NWV2 Q92474
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    June 10, 2008 (Entry version 92)
Name and origin of the protein
Protein name Activin receptor type-2A [Precursor]
Synonyms EC 2.7.11.30
Activin receptor type IIA
ACTR-IIA
ACTRIIA
Gene name
Name: ACVR2A
Synonyms: ACVR2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/0167-4781(92)90472-C; PubMed=1311955 [NCBI, ExPASy, EBI, Israel, Japan]
Matzuk M.M., Bradley A.;
"Cloning of the human activin receptor cDNA reveals high evolutionary conservation.";
Biochim. Biophys. Acta 1130:105-108(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
DOI=10.1016/0006-291X(92)91194-U; PubMed=1314589 [NCBI, ExPASy, EBI, Israel, Japan]
Donaldson C.J., Mathews L.S., Vale W.W.;
"Molecular cloning and binding properties of the human type II activin receptor.";
Biochem. Biophys. Res. Commun. 184:310-316(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
Geiser A.G.;
Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Iimura T., Oida S.;
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
VARIANTS ARG-258 AND ASN-306.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X63128; CAA44839.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M93415; AAA35504.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X62381; CAA44245.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D31770; BAA06548.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067418; AAH67418.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC009480; AAX93050.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067417; AAH67417.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069707; AAH69707.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ1486; JQ1486.
RefSeq NP_001607.1; -.
UniGene Hs.470174
3D structure databases
HSSP P27038; 1BTE. [HSSP ENTRY / PDB]
SMR P27037; 26-119.
ModBase P27037.
Protein-protein interaction databases
DIP DIP:520N; -.
IntAct P27037; -.
PTM databases
PhosphoSite P27037; -.
Organism-specific databases
H-InvDB HIX0029973; -.
HGNC HGNC:173; ACVR2A.
GeneLynx ACVR2A; Homo sapiens.
GenAtlas ACVR2A.
MIM 102581; gene. [NCBI / EBI]
PharmGKB PA24494; -.
GeneCards P27037.
Gene expression databases
ArrayExpress P27037; -.
CleanEx HS_ACVR2A; -.
GermOnline ENSG00000121989; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HGNC).
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0048186; Molecular function: inhibin beta-A binding (inferred from direct assay from HGNC).
GO:0004675; Molecular function: transmembrane receptor protein serine/threonine kinase activity (traceable author statement from ProtInc).
GO:0030509; Biological process: BMP signaling pathway (inferred from experiment from Reactome).
GO:0032927; Biological process: positive regulation of activin receptor signaling pathway (inferred from direct assay from HGNC).
GO:0045648; Biological process: positive regulation of erythrocyte differentiation (inferred from direct assay from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR015768; Activin_II_recpt_C.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
PANTHER PTHR23255:SF10; Activin_II_recpt_C; 1.
Pfam PF01064; Activin_recp; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P27037.
Genome annotation databases
Ensembl ENSG00000121989; Homo sapiens. [Contig view]
GeneID 92; -.
KEGG hsa:92; -.
NMPDR fig|9606.3.peg.18734; -.
Phylogenomic databases
HOGENOM P27037; -.
HOVERGEN P27037; -.
Other
LinkHub P27037; -.
SOURCE ACVR2A; Homo sapiens.
ProtoNet P27037.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Polymorphism; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   513  494     Activin receptor type-2A. PRO_0000024398
TOPO_DOM   20   135  116     Extracellular (Potential). 
TRANSMEM   136   161  26     Potential. 
TOPO_DOM   162   513  352     Cytoplasmic (Potential). 
DOMAIN   192   485  294     Protein kinase. 
NP_BIND   198   206  9     ATP (By similarity). 
ACT_SITE   322   322        Proton acceptor (By similarity). 
BINDING   219   219        ATP (By similarity). 
CARBOHYD   43    43        N-linked (GlcNAc...) (Potential). 
CARBOHYD   66    66        N-linked (GlcNAc...) (Potential). 
DISULFID   30    60        By similarity. 
DISULFID   50    78        By similarity. 
DISULFID   85   104        By similarity. 
DISULFID   91   103        By similarity. 
DISULFID   105   110        By similarity. 
VARIANT   258   258  1     S -> R. VAR_032809 
VARIANT   306   306  1     D -> N (in a gastric adenocarcinoma sample; somatic mutation). VAR_032810 
CONFLICT   13    13        L -> V (in Ref. 4; BAA06548). 
CONFLICT   204   206        GCV -> PSL (in Ref. 4; BAA06548). 
CONFLICT   348   348        E -> V (in Ref. 4; BAA06548). 
CONFLICT   507   507        P -> L (in Ref. 6; AAH67417). 
Sequence information
Length: 513 AA [This is the length of the unprocessed precursor] Molecular weight: 57848 Da [This is the MW of the unprocessed precursor] CRC64: A89822E880979618 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC 

        70         80         90        100        110        120 
FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM 

       130        140        150        160        170        180 
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 

       190        200        210        220        230        240 
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 

       250        260        270        280        290        300 
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 

       310        320        330        340        350        360 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 

       370        380        390        400        410        420 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 

       430        440        450        460        470        480 
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 

       490        500        510 
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 

P27037 in FASTA format

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