[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1093/nar/20.11.2667; PubMed=1614852 [NCBI, ExPASy, EBI, Israel, Japan] Hammond J.M., Kerr S.M., Smith G.L., Dixon L.K.; "An African swine fever virus gene with homology to DNA ligases."; Nucleic Acids Res. 20:2667-2671(1992).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8021596 [NCBI, ExPASy, EBI, Israel, Japan] Dixon L.K., Twigg S.R.F., Baylis S.A., Vydelingum S., Bristow C., Hammond J.M., Smith G.L.; "Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1)."; J. Gen. Virol. 75:1655-1684(1994).

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA. It is not essential for viral replication and recombination.
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X65192; CAA46310.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X71982; CAA50805.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S23018; S23018.

3D structure databases

ModBase

P26813.

Family and domain databases

InterPro

IPR012310; DNA_ligase_A_M.
IPR016059; DNA_ligase_CS.
Graphical view of domain structure.

Pfam

PF01068; DNA_ligase_A_M; 1.
Pfam graphical view of domain structure.

PROSITE

PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 419`	`419`	`DNA ligase.`	`PRO_0000059594`
`ACT_SITE`	`151 151`		`N6-AMP-lysine intermediate (By similarity).`

Sequence information

Length: 419 AA [This is the length of the unprocessed precursor]

Molecular weight: 48041 Da [This is the MW of the unprocessed precursor]

CRC64: DA781C64CA1B10F0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLSQFPGQCS NNVFCFPPIE SETKNGKKAS WIICVQVMQH NTILPITDEM FSTDVKDAVA 

        70         80         90        100        110        120 
EIFTKFFVEE GAVRISKTTR VTEGKNLGKK NATTVVHQAF KDALSKYNRH ARQKRGAHTN 

       130        140        150        160        170        180 
RGMIPPMLVK YFNIIPKTFF EEETDPIVHG KRNGVRAVAC QQGDGSILLY SRTEKEFLGL 

       190        200        210        220        230        240 
DNIKKELKQL YLFIDVRVYL DGELYLHRKP LQWIAGQANA KADSSELHFY VFDCFWSDQL 

       250        260        270        280        290        300 
QMPSNKRQQL LTNIFKQKED LTFIHQVENF SVKNEDEALR LKTQFIKEGY EGAIVRNANG 

       310        320        330        340        350        360 
PYEPGYNNYH SPHLAKLKPL LDAEFILVDY TQGKKGKDLG AILWVCELPN KKRFVVTPKH 

       370        380        390        400        410 
LTYADRYALF QKLTPALFKK HLYGKELTVE YAELSPKTGI PLQARAVGFR EPINVLEII

P26813 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools