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UniProtKB/Swiss-Prot entry P26770

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADCY4_RAT
Primary accession number P26770
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Adenylate cyclase type 4
Synonyms EC 4.6.1.1
Adenylate cyclase type IV
ATP pyrophosphate-lyase 4
Adenylyl cyclase 4
Gene name
Name: Adcy4
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=1946437 [NCBI, ExPASy, EBI, Israel, Japan]
Gao B., Gilman A.G.;
"Cloning and expression of a widely distributed (type IV) adenylyl cyclase.";
Proc. Natl. Acad. Sci. U.S.A. 88:10178-10182(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M80633; AAA40665.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A41542; A41542.
UniGene Rn.1904
3D structure databases
HSSP P26769; 1CJK. [HSSP ENTRY / PDB]
SMR P26770; 854-1053.
ModBase P26770.
PTM databases
PhosphoSite P26770; -.
Organism-specific databases
RGD 2034; Adcy4.
Gene expression databases
ArrayExpress P26770; -.
GermOnline ENSRNOG00000020401; Rattus norvegicus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
IPR009398; Aden_cycl_like.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 2.
Pfam PF06327; DUF1053; 1.
PF00211; Guanylate_cyc; 2.
Pfam graphical view of domain structure.
SMART SM00044; CYCc; 2.
SMART graphical view of domain structure.
PROSITE PS00452; GUANYLATE_CYCLASE_1; 2.
PS50125; GUANYLATE_CYCLASE_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS P26770.
ProtoNet P26770.
Genome annotation databases
Ensembl ENSRNOG00000020401; Rattus norvegicus. [Contig view]
Phylogenomic databases
HOVERGEN P26770; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Repeat; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1064  1064     Adenylate cyclase type 4. PRO_0000195692
TOPO_DOM   1     28  28     Cytoplasmic (Potential). 
TRANSMEM   29     50  22     Potential. 
TRANSMEM   61     80  20     Potential. 
TRANSMEM   94    117  24     Potential. 
TRANSMEM   120    138  19     Potential. 
TRANSMEM   141    162  22     Potential. 
TRANSMEM   170    190  21     Potential. 
TOPO_DOM   191    582  392     Cytoplasmic (Potential). 
TRANSMEM   583    604  22     Potential. 
TRANSMEM   608    630  23     Potential. 
TRANSMEM   661    684  24     Potential. 
TOPO_DOM   685    707  23     Extracellular (Potential). 
TRANSMEM   708    733  26     Potential. 
TRANSMEM   741    761  21     Potential. 
TRANSMEM   788    804  17     Potential. 
TOPO_DOM   805   1064  260     Cytoplasmic (Potential). 
METAL   278    278        Magnesium 1 (By similarity). 
METAL   278    278        Magnesium 2 (By similarity). 
METAL   279    279        Magnesium 2; via carbonyl oxygen (By similarity). 
METAL   322    322        Magnesium 1 (By similarity). 
METAL   322    322        Magnesium 2 (By similarity). 
CARBOHYD   694    694        N-linked (GlcNAc...) (Potential). 
CARBOHYD   701    701        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1064 AA [This is the length of the unprocessed precursor] Molecular weight: 118799 Da [This is the MW of the unprocessed precursor] CRC64: 5A2A0B895B5A0DA8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARLFSPRPP PSEDLFYETY YSLSQQYPLL ILLLVIVLCA IVALPAVAWA SGRELTSDPS 

        70         80         90        100        110        120 
FLTTVLCALG GFSLLLGLAS REQQLQRWTR PLSGLIWAAL LALGYGFLFT GGVVSAWDQV 

       130        140        150        160        170        180 
SFFLFIIFTV YAMLPLGMRD AAAAGVISSL SHLLVLGLYL GWRPESQRDL LPQLAANAVL 

       190        200        210        220        230        240 
FLCGNVVGAY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 

       250        260        270        280        290        300 
AEIMARLQAG QSSRPENTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 

       310        320        330        340        350        360 
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRVATG 

       370        380        390        400        410        420 
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 

       430        440        450        460        470        480 
AYAVERADME HRDPYLRELG EPTYLVIDPW AEEEDEKGTE RGLLSSLEGH TMRPSLLMTR 

       490        500        510        520        530        540 
YLESWGAAKP FAHLSHVDSP ASTSTPLPEK AFSPQWSLDR SRTPRGLHDE LDTGDAKFFQ 

       550        560        570        580        590        600 
VIEQLNSQKQ WKQSKDFNLL TLYFREKEME KQYRLSALPA FKYYAACTFL VFLSNFTIQM 

       610        620        630        640        650        660 
LVTTRPPALA TTYSITFLLF LLLLFVCFSE HLTKCVQKGP KMLHWLPALS VLVATRPGLR 

       670        680        690        700        710        720 
VALGTATILL VFTMAVVSLL FLPVSSDCPF LAPNVSSVAF NTSWELPASL PLISIPYSMH 

       730        740        750        760        770        780 
CCVLGFLSCS LFLHMSFELK LLLLLLWLVA SCSLFLHSHA WLSDCLIARL YQGSLGSRPG 

       790        800        810        820        830        840 
VLKEPKLMGA IYFFIFFFTL LVLARQNEYY CRLDFLWKKK LRQEREETET MENVLPAHVA 

       850        860        870        880        890        900 
PQLIGQNRRN EDLYHQSYEC VCVLFASIPD FKEFYSESNI NHEGLECLRL LNEIIADFDE 

       910        920        930        940        950        960 
LLSKPKFSGV EKIKTIGSTY MAATGLNATP GQDTQQDAER SCSHLGTMVE FAVALGSKLG 

       970        980        990       1000       1010       1020 
VINKHSFNNF RLRVGLNHGP VVAGVIGAQK PQYDIWGNTV NVASRMESTG VLGKIQVTEE 

      1030       1040       1050       1060 
TARALQSLGY TCYSRGVIKV KGKGQLCTYF LNTDLTRTGS PSAS
P26770 in FASTA format

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