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UniProtKB/Swiss-Prot entry P26762

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BVGS_BORBR
Primary accession number P26762
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on September 19, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 83)
Name and origin of the protein
Protein name Virulence sensor protein bvgS [Precursor]
Synonym EC 2.7.13.3
Gene name
Name: bvgS
OrderedLocusNames: BB2995
From
Bordetella bronchiseptica (Alcaligenes bronchisepticus) [TaxID: 518] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=7865;
PubMed=1791760 [NCBI, ExPASy, EBI, Israel, Japan]
Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R.;
"Structural and genetic analysis of the bvg locus in Bordetella species.";
Mol. Microbiol. 5:2481-2491(1991).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RB50 / ATCC BAA-588 / NCTC 13252;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X58355; CAA41252.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX640446; CAE33487.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S17944; S17944.
RefSeq NP_889531.1; -.
3D structure databases
HSSP P49333; 1DCF. [HSSP ENTRY / PDB]
ModBase P26762.
Enzyme and pathway databases
BioCyc BBRO257310:BB2995-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0030288; Cellular component: outer membrane-bounded periplasmic space (inferred from electronic annotation from InterPro).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005215; Molecular function: transporter activity (inferred from electronic annotation from InterPro).
GO:0000156; Molecular function: two-component response regulator activity (inferred from electronic annotation from InterPro).
GO:0000155; Molecular function: two-component sensor activity (inferred from electronic annotation from InterPro).
GO:0009405; Biological process: pathogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0018106; Biological process: peptidyl-histidine phosphorylation (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from InterPro).
GO:0006810; Biological process: transport (inferred from electronic annotation from InterPro).
GO:0000160; Biological process: two-component signal transduction system (phosphorelay) (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR003594; ATP_bd_ATPase.
IPR000014; PAS.
IPR000700; PAS-assoc_C.
IPR013767; PAS_fold.
IPR001638; SBP_bac_3.
IPR004358; Sig_transdc_His_kin-like_C.
IPR008207; Sig_transdc_His_kin_P-trf.
IPR003661; Sig_transdc_His_kin_sub1_dim/P.
IPR005467; Sig_transdc_His_kinase_core.
IPR001789; Sig_transdc_resp-reg_receiver.
Graphical view of domain structure.
Gene3D G3DSA:3.30.565.10; ATP_bd_ATPase; 1.
Pfam PF02518; HATPase_c; 1.
PF00512; HisKA; 1.
PF01627; Hpt; 1.
PF00989; PAS; 1.
PF00072; Response_reg; 1.
PF00497; SBP_bac_3; 1.
Pfam graphical view of domain structure.
PRINTS PR00344; BCTRLSENSOR.
ProDom PD000039; Response_reg; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00387; HATPase_c; 1.
SM00388; HisKA; 1.
SM00073; HPT; 1.
SM00091; PAS; 1.
SM00062; PBPb; 2.
SM00448; REC; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00229; sensory_box; 1.
PROSITE PS50109; HIS_KIN; 1.
PS50894; HPT; 1.
PS50113; PAC; 1.
PS50112; PAS; 1.
PS50110; RESPONSE_REGULATORY; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P26762.
ProtoNet P26762.
Genome annotation databases
GeneID 2659742; -.
GenomeReviews BX470250_GR; BB2995.
KEGG bbr:BB2995; -.
NMPDR fig|257310.1.peg.2978; -.
Phylogenomic databases
HOGENOM P26762; -.
Genome annotation databases
CMR P26762; BB2995.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell inner membrane; Cell membrane; Complete proteome; Kinase; Membrane; Phosphoprotein; Signal; Transferase; Transmembrane; Two-component regulatory system; Virulence.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     30  30     Potential. 
CHAIN   31   1238  1208     Virulence sensor protein bvgS. PRO_0000032368
TOPO_DOM   33    307  275     Cytoplasmic (Potential). 
TRANSMEM   308    331  24     Potential. 
TOPO_DOM   332    541  210     Periplasmic (Potential). 
TRANSMEM   542    563  22     Potential. 
TOPO_DOM   564   1238  675     Cytoplasmic (Potential). 
DOMAIN   580    651  72     PAS. 
DOMAIN   652    708  57     PAC. 
DOMAIN   726    948  223     Histidine kinase. 
DOMAIN   974   1095  122     Response regulatory. 
DOMAIN   1133   1228  96     HPt. 
MOD_RES   729    729        Phosphohistidine; by autocatalysis (By similarity). 
MOD_RES   1023   1023        4-aspartylphosphate (By similarity). 
MOD_RES   1172   1172        Phosphohistidine (By similarity). 
CONFLICT   50     50        A -> T (in Ref. 1; CAA41252). 
CONFLICT   395    395        M -> L (in Ref. 1; CAA41252). 
CONFLICT   651    651        S -> A (in Ref. 1; CAA41252). 
CONFLICT   1008   1008        A -> S (in Ref. 1; CAA41252). 
CONFLICT   1067   1068        QR -> HA (in Ref. 1; CAA41252). 
CONFLICT   1144   1144        L -> V (in Ref. 1; CAA41252). 
Sequence information
Length: 1238 AA [This is the length of the unprocessed precursor] Molecular weight: 134811 Da [This is the MW of the unprocessed precursor] CRC64: 74DCB538B77A0F3E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA LDGDDWRWLA 

        70         80         90        100        110        120 
RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL GVQAKVLRYP TREQAVGALE 

       130        140        150        160        170        180 
SGQIDLIGTV NGIEGRLQSL RLSVPYAADH PVLVMPIGAR RAPPADLAGQ RLAVDANYLP 

       190        200        210        220        230        240 
RETLQQAYPQ ATLHYFPSSE QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ 

       250        260        270        280        290        300 
IVTGGESFGV RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ 

       310        320        330        340        350        360 
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI IGVDTVEELI 

       370        380        390        400        410        420 
AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR QDPAAPADAD HLDGRTIAMV 

       430        440        450        460        470        480 
RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL VADGQADAVV QTQISASYYV NRYFAGKLRI 

       490        500        510        520        530        540 
ASALDLPPAE IALATARGQT ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN 

       550        560        570        580        590        600 
EIYLLIGLGL LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK 

       610        620        630        640        650        660 
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM SAEREPRFED 

       670        680        690        700        710        720 
RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA ELLRELHDAK ESADAANRAK 

       730        740        750        760        770        780 
TTFLATMSHE IRTPMNAIIG MLELALLRPA DQEPDRQSIQ VAYDSARSLL ELIGDILDIA 

       790        800        810        820        830        840 
KIEAGKFDLA PVRTALRALP EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV 

       850        860        870        880        890        900 
LSNLVGNAIK FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG 

       910        920        930        940        950        960 
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE KSAQATPPAA 

       970        980        990       1000       1010       1020 
AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV AADSGEAALA LWHEHAFDVV 

      1030       1040       1050       1060       1070       1080 
ITDCNMPGIN GYELARRIRA AEAAPGYGRT RCILFGFTAS AQMDEAQRCR AAGMDDCLFK 

      1090       1100       1110       1120       1130       1140 
PIGVDALRQR LNEAAARAAL PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL 

      1150       1160       1170       1180       1190       1200 
LEELIRTNRA DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ 

      1210       1220       1230 
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP
P26762 in FASTA format

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