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UniProtKB/Swiss-Prot entry P26364


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KAD2_YEAST
Primary accession number P26364
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 74)
Name and origin of the protein
Protein name Adenylate kinase 2
Synonyms AK 2
EC 2.7.4.3
ATP-AMP transphosphorylase 2
Gene name
Name: ADK2
Synonyms: PAK3
OrderedLocusNames: YER170W
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(92)90721-Z; PubMed=1587477 [NCBI, ExPASy, EBI, Israel, Japan]
Cooper A.J., Friedberg E.C.;
"A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae.";
Gene 114:145-148(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DL-1;
DOI=10.1007/BF00265432; PubMed=1620094 [NCBI, ExPASy, EBI, Israel, Japan]
Schricker R., Magdolen V., Bandlow W.;
"A new member of the adenylate kinase family in yeast: PAK3 is highly homologous to mammalian AK3 and is targeted to mitochondria.";
Mol. Gen. Genet. 233:363-371(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169868 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
Nature 387:78-81(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M77757; AAA34418.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X65126; CAA46254.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U18922; AAB64697.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY558457; AAS56783.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S23568; S23568.
RefSeq NP_011097.1; -.
3D structure databases
HSSP P08760; 2AK3. [HSSP ENTRY / PDB]
ModBase P26364.
Protein-protein interaction databases
DIP DIP:4877N; -.
IntAct P26364; -.
Organism-specific databases
CYGD YER170w; -.
SGD S000000972; ADK2.
Yeast-GFP YER170W.
Gene expression databases
GermOnline YER170W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from SGD).
GO:0004017; Molecular function: adenylate kinase activity (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0046899; Molecular function: nucleoside triphosphate adenylate kinase activity (inferred from direct assay from SGD).
GO:0009117; Biological process: nucleotide metabolic process (inferred from direct assay from SGD).
QuickGo view.
Family and domain databases
InterPro IPR006259; Adenyl_kin_sub.
IPR000850; Adenylate_kin.
IPR007862; Adenylate_kinase_Znf_lid.
Graphical view of domain structure.
PANTHER PTHR23359; Adenylate_kin; 1.
Pfam PF00406; ADK; 1.
PF05191; ADK_lid; 1.
Pfam graphical view of domain structure.
PRINTS PR00094; ADENYLTKNASE.
ProDom PD000657; Adenylate_kin; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01351; adk; 1.
PROSITE PS00113; ADENYLATE_KINASE; 1.
BLOCKS P26364.
ProtoNet P26364.
Genome annotation databases
Ensembl YER170W; Saccharomyces cerevisiae. [Contig view]
GeneID 856917; -.
GenomeReviews U00092_GR; YER170W.
KEGG sce:YER170W; -.
NMPDR fig|4932.3.peg.2183; -.
Phylogenomic databases
HOGENOM P26364; -.
Other
LinkHub P26364; -.
NextBio 983371; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Mitochondrion; Nucleotide-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   225  225     Adenylate kinase 2. PRO_0000158907
NP_BIND   21    29  9     ATP (By similarity). 
Sequence information
Length: 225 AA [This is the length of the unprocessed precursor] Molecular weight: 25194 Da [This is the MW of the unprocessed precursor] CRC64: 3B192BE2535BF91F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKADAKQITH LLKPLRLLLL GAPGSGKGTQ TSRLLKQIPQ LSSISSGDIL RQEIKSESTL 

        70         80         90        100        110        120 
GREATTYIAQ GKLLPDDLIT RLITFRLSAL GWLKPSAMWL LDGFPRTTAQ ASALDELLKQ 

       130        140        150        160        170        180 
HDASLNLVVE LDVPESTILE RIENRYVHVP SGRVYNLQYN PPKVPGLDDI TGEPLTKRLD 

       190        200        210        220 
DTAEVFKKRL EEYKKTNEPL KDYYKKSGIF GTVSGETSDI IFRNY 

P26364 in FASTA format

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