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UniProtKB/Swiss-Prot entry P26338

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYAA_TRYEQ
Primary accession number P26338
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on May 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name Receptor-type adenylate cyclase [Fragment]
Synonyms EC 4.6.1.1
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene name
Name: ESAG4C
From
Trypanosoma equiperdum [TaxID: 5694] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CL;
PubMed=2065652 [NCBI, ExPASy, EBI, Israel, Japan]
Ross D.T., Raibaud A., Florent I.C., Sather S., Gross M.K., Storm D.R., Eisen H.;
"The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.";
EMBO J. 10:2047-2053(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X59386; CAA42029.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S16359; S16359.
3D structure databases
HSSP Q99279; 1FX2. [HSSP ENTRY / PDB]
SMR P26338; 90-324.
ModBase P26338.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 1.
Pfam PF00211; Guanylate_cyc; 1.
Pfam graphical view of domain structure.
SMART SM00044; CYCc; 1.
SMART graphical view of domain structure.
PROSITE PS50125; GUANYLATE_CYCLASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P26338.
ProtoNet P26338.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Cell membrane; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Receptor; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   <1   469  >469     Receptor-type adenylate cyclase. PRO_0000195741
TOPO_DOM   <1    59  >59     Extracellular (Potential). 
TRANSMEM   60    80  21     Potential. 
TOPO_DOM   81   469  389     Cytoplasmic (Potential). 
DOMAIN   103   257  155     Guanylate cyclase. 
METAL   108   108        Magnesium (By similarity). 
METAL   151   151        Magnesium (By similarity). 
CARBOHYD   31    31        N-linked (GlcNAc...) (Potential). 
NON_TER   1     1         
Sequence information
Length: 469 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 50819 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: F87638C3152DEA3A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
VDTAEKLSKN GCASNYGATQ ISVWSMARAL NASIPPLTNP MTPSMTFRNS NAGRISGVAL 

        70         80         90        100        110        120 
VGVIIGGALA LFLVVALGVV PYFFLHNTRD NNLAPKELTD PVTLIFTDIE SSTALWAAHP 

       130        140        150        160        170        180 
ELMPDAVATH HRLIRSLIGR YGCYEVKTVG DSFMIASKSP FAAVQLAQEL QLCFLHHDWG 

       190        200        210        220        230        240 
TNAIDESYQQ LEQQRAEEDA KYTPPTARLD LKVYSRLWNG LRVRVGIHTG LCDIRRDEVT 

       250        260        270        280        290        300 
KGYDYYGRTS NMAARTESVG NGGQVLMTTA AYMSLSAEER EQIDVTALGD VPLRGVAKPV 

       310        320        330        340        350        360 
EMYQLNAVPG RTFAGLRLEH ELLNDDEDQT TTSCSDHSSS RTDLSVAAQT IAASLQSLLG 

       370        380        390        400        410        420 
TFTPAQRQKA LIPFCERWRV PLPQKVGNVW DNDGCQEAIR RVAAKVGRVM DFGTRKASSS 

       430        440        450        460 
VTSLERGGSL FSAGGATVAT VASSSNFSCV DGRCGTVQLI DLENDSTTS
P26338 in FASTA format

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View entry in raw text format (no links)
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