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UniProtKB/Swiss-Prot entry P26232


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CTNA2_HUMAN
Primary accession number P26232
Secondary accession numbers B3KXE5 Q4ZFW1 Q53R26 Q53R33 Q53T67 Q53T71 Q53TM8 Q7Z3Y0
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 5)
Annotations were last modified on    June 16, 2009 (Entry version 87)
Name and origin of the protein
Protein name Catenin alpha-2
Synonyms Alpha-catenin-related protein
Alpha N-catenin
Gene name
Name: CTNNA2
Synonyms: CAPR
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1006/geno.1993.1004; PubMed=8432524 [NCBI, ExPASy, EBI, Israel, Japan]
Claverie J.-M., Hardelin J.-P., Legouis R., Levilliers J., Bougueleret L., Mattei M.-G., Petit C.;
"Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin).";
Genomics 15:13-20(1993).
[2]
SEQUENCE REVISION TO C-TERMINUS.
Hardelin J.-P.;
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Hippocampus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=PNS;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
[7]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M94151; AAA58407.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC096573; AAY14758.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK127226; BAG54457.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC096753; AAY14763.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC011746; AAY15008.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC104780; AAX88946.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC011741; AAX93241.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC008067; AAY15073.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC052996; AAH52996.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00385055; -.
IPI00743859; -.
PIR A45011; A45011.
RefSeq NP_004380.2; -.
UniGene Hs.167368
3D structure databases
HSSP P35221; 1L7C. [HSSP ENTRY / PDB]
SMR P26232; 56-260, 390-630.
ModBase P26232.
PTM databases
PhosphoSite P26232; -.
Organism-specific databases
GeneCards GC02P079265; -.
HGNC HGNC:2510; CTNNA2.
GenAtlas CTNNA2.
MIM 114025; gene. [NCBI / EBI]
PharmGKB PA27009; -.
Gene expression databases
Bgee P26232; -.
CleanEx HS_CTNNA2; -.
GermOnline ENSG00000066032; Homo sapiens.
Ontologies
GO
GO:0015629; Cellular component: actin cytoskeleton (inferred from electronic annotation from InterPro).
GO:0005912; Cellular component: adherens junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0045296; Molecular function: cadherin binding (inferred from electronic annotation from InterPro).
GO:0005200; Molecular function: structural constituent of cytoskeleton (non-traceable author statement from UniProtKB).
GO:0007155; Biological process: cell adhesion (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001033; Alpha_catenin.
IPR006077; Vinculin/catenin.
IPR000633; Vinculin_CS.
Graphical view of domain structure.
Pfam PF01044; Vinculin; 2.
Pfam graphical view of domain structure.
PRINTS PR00805; ALPHACATENIN.
PROSITE PS00663; VINCULIN_1; 1.
Proteomic databases
PRIDE P26232; -.
Genome annotation databases
Ensembl ENSG00000066032; Homo sapiens. [Contig view]
GeneID 1496; -.
KEGG hsa:1496; -.
Phylogenomic databases
HOVERGEN P26232; -.
Other
NextBio 6149; -.
SOURCE CTNNA2; Homo sapiens.
ProtoNet P26232.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   953  952     Catenin alpha-2. PRO_0000064263
MOD_RES   2     2        N-acetylthreonine (By similarity). 
MOD_RES   5     5        Phosphothreonine (By similarity). 
MOD_RES   6     6        Phosphoserine (By similarity). 
MOD_RES   151   151        Phosphoserine. 
MOD_RES   261   261        Phosphothreonine (By similarity). 
MOD_RES   262   262        Phosphoserine (By similarity). 
MOD_RES   640   640        Phosphoserine (By similarity). 
MOD_RES   653   653        Phosphothreonine (By similarity). 
MOD_RES   654   654        Phosphoserine (By similarity). 
MOD_RES   657   657        Phosphothreonine (By similarity). 
MOD_RES   901   901        Phosphoserine (By similarity). 
VAR_SEQ   811   858        Missing (in isoform 2). VSP_020337
CONFLICT   182   182        E -> K (in Ref. 1; AAA58407). 
CONFLICT   309   309        S -> SS (in Ref. 2; AAY15008). 
CONFLICT   651   652        SR -> RG (in Ref. 1; AAA58407). 
Sequence information
Length: 953 AA [This is the length of the unprocessed precursor] Molecular weight: 105313 Da [This is the MW of the unprocessed precursor] CRC64: 5FC88907B37E8A6C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 

        70         80         90        100        110        120 
AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 

       130        140        150        160        170        180 
GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 

       190        200        210        220        230        240 
KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 

       250        260        270        280        290        300 
DYVFKQVQEA IAGISNAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 

       310        320        330        340        350        360 
PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 

       370        380        390        400        410        420 
PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 

       430        440        450        460        470        480 
FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 

       490        500        510        520        530        540 
NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 

       550        560        570        580        590        600 
GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 

       610        620        630        640        650        660 
PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 

       670        680        690        700        710        720 
QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 

       730        740        750        760        770        780 
IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 

       790        800        810        820        830        840 
RIALYCHQLN ICSKVKAEVQ NLGGELIVSG TGVQSTFTTF YEVDCDVIDG GRASQLSTHL 

       850        860        870        880        890        900 
PTCAEGAPIG SGSSDSSMLD SATSLIQAAK NLMNAVVLTV KASYVASTKY QKVYGTAAVN 

       910        920        930        940        950 
SPVVSWKMKA PEKKPLVKRE KPEEFQTRVR RGSQKKHISP VQALSEFKAM DSF 

P26232 in FASTA format

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