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UniProtKB/Swiss-Prot entry P26196


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDX6_HUMAN
Primary accession number P26196
Secondary accession number Q5D048
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on October 17, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 92)
Name and origin of the protein
Protein name Probable ATP-dependent RNA helicase DDX6
Synonyms EC 3.6.1.-
DEAD box protein 6
ATP-dependent RNA helicase p54
Oncogene RCK
Gene name
Name: DDX6
Synonyms: HLR2, RCK
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/20.8.1967; PubMed=1579499 [NCBI, ExPASy, EBI, Israel, Japan]
Lu D., Yunis J.J.;
"Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3.";
Nucleic Acids Res. 20:1967-1972(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 12-483.
TISSUE=Lung;
PubMed=1394235 [NCBI, ExPASy, EBI, Israel, Japan]
Akao Y., Seto M., Yamamoto K., Iida S., Nakazawa S., Inazawa J., Abe T., Takahashi T., Ueda R.;
"The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations.";
Cancer Res. 52:6083-6087(1992).
[4]
IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DCP1A; DCP2; EDC3 AND EDC4, AND SUBCELLULAR LOCATION.
DOI=10.1016/j.molcel.2005.10.031; PubMed=16364915 [NCBI, ExPASy, EBI, Israel, Japan]
Fenger-Groen M., Fillman C., Norrild B., Lykke-Andersen J.;
"Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.";
Mol. Cell 20:905-915(2005).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
[6]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 94-299.
PubMed=14684915 [NCBI, ExPASy, EBI, Israel, Japan]
Matsui T., Hogetsu K., Akao Y., Tanaka M., Sato T., Kumasaka T., Tanaka N.;
"Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54.";
Acta Crystallogr. D 60:156-159(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z11685; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
BC065007; AAH65007.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D17532; BAA04482.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S22651; S22651.
RefSeq NP_004388.2; -.
UniGene Hs.654366
3D structure databases
PDB
1VEC; X-ray; 2.01 A; A/B=94-299.[ExPASy / RCSB / EBI]
PDBsum 1VEC; -.
ModBase P26196.
Protein-protein interaction databases
DIP DIP:29195N; -.
IntAct P26196; -.
PTM databases
PhosphoSite P26196; -.
2D gel databases
DOSAC-COBS-2DPAGE P26196; -.
Organism-specific databases
HGNC HGNC:2747; DDX6.
GenAtlas DDX6.
HPA CAB004668; -.
MIM 600326; gene. [NCBI / EBI]
PharmGKB PA27229; -.
GeneCards P26196.
Gene expression databases
ArrayExpress P26196; -.
CleanEx HS_DDX6; -.
GermOnline ENSG00000110367; Homo sapiens.
Ontologies
GO
GO:0010494; Cellular component: stress granule (inferred from direct assay from UniProtKB).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008026; Molecular function: ATP-dependent helicase activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003724; Molecular function: RNA helicase activity (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR000629; RNA-helicase_DEAD-box_CS.
IPR014014; RNA_helicase_DEAD_Q_motif.
Graphical view of domain structure.
Pfam PF00270; DEAD; 1.
PF00271; Helicase_C; 1.
Pfam graphical view of domain structure.
SMART SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.
PROSITE PS00039; DEAD_ATP_HELICASE; 1.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PS51195; Q_MOTIF; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P26196.
ProtoNet P26196.
Proteomic databases
PeptideAtlas P26196; -.
Genome annotation databases
Ensembl ENSG00000110367; Homo sapiens. [Contig view]
GeneID 1656; -.
KEGG hsa:1656; -.
Phylogenomic databases
HOGENOM P26196; -.
HOVERGEN P26196; -.
Other
LinkHub P26196; -.
NextBio 6820; -.
SOURCE DDX6; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Chromosomal rearrangement; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding; Phosphoprotein; Proto-oncogene; RNA-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   483  483     Probable ATP-dependent RNA helicase DDX6. PRO_0000054983
DOMAIN   127   298  172     Helicase ATP-binding. 
DOMAIN   308   468  161     Helicase C-terminal. 
NP_BIND   140   147  8     ATP (By similarity). 
MOTIF   96   124  29     Q motif. 
MOTIF   246   249  4     DEAD box. 
MOD_RES   36    36        Phosphothreonine. 
CONFLICT   293   293        Q -> E (in Ref. 1; Z11685). 
HELIX   98   100  3      
HELIX   105   112  8      
TURN   113   115  3      
HELIX   121   131  11      
STRAND   136   139  4      
STRAND   142   144  3      
HELIX   147   157  11      
STRAND   167   170  4      
HELIX   174   187  14      
TURN   188   190  3      
STRAND   191   193  3      
STRAND   196   199  4      
STRAND   201   203  3      
HELIX   205   211  7      
STRAND   217   221  5      
HELIX   223   231  9      
STRAND   242   247  6      
HELIX   248   251  4      
TURN   254   256  3      
HELIX   257   266  10      
STRAND   272   278  7      
HELIX   282   291  10      
STRAND   296   298  3      
Sequence information
Length: 483 AA [This is the length of the unprocessed precursor] Molecular weight: 54417 Da [This is the MW of the unprocessed precursor] CRC64: F802C642861793FB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSTARTENPV IMGLSSQNGQ LRGPVKPTGG PGGGGTQTQQ QMNQLKNTNT INNGTQQQAQ 

        70         80         90        100        110        120 
SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS 

       130        140        150        160        170        180 
PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV 

       190        200        210        220        230        240 
SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVDHV 

       250        260        270        280        290        300 
QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL 

       310        320        330        340        350        360 
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS 

       370        380        390        400        410        420 
CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH 

       430        440        450        460        470        480 
RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED 


EKP 

P26196 in FASTA format

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