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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1904855 [NCBI, ExPASy, EBI, Israel, Japan]
Hakura A.,
Morimoto K.,
Sofuni T.,
Nohmi T.;
"Cloning and characterization of the Salmonella typhimurium ada gene, which encodes O6-methylguanine-DNA methyltransferase.";
J. Bacteriol. 173:3663-3672(1991).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LT2 / SGSC1412 / ATCC 700720;
DOI=10.1038/35101614; PubMed=11677609 [NCBI, ExPASy, EBI, Israel, Japan]
McClelland M.,
Sanderson K.E.,
Spieth J.,
Clifton S.W.,
Latreille P.,
Courtney L.,
Porwollik S.,
Ali J.,
Dante M.,
Du F.,
Hou S.,
Layman D.,
Leonard S.,
Nguyen C.,
Scott K.,
Holmes A.,
Grewal N.,
Mulvaney E.,
Ryan E., ![]()
Sun H.,
Florea L.,
Miller W.,
Stoneking T.,
Nhan M.,
Waterston R.,
Wilson R.K.;
"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
Nature 413:852-856(2001).
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- FUNCTION: Repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Can also repair O-4-methylthymine.
- FUNCTION: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB.
- CATALYTIC ACTIVITY: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
- SIMILARITY: In the C-terminal section; belongs to the MGMT family.
- SIMILARITY: Contains 1 HTH araC/xylS-type DNA-binding domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 353 AA [This is the length of the unprocessed precursor] |
Molecular weight: 39348 Da [This is the MW of the unprocessed precursor] |
CRC64: ACE9E13C7EF6C114 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MMKKALLIDD ECWLRVQARD ASADGRFVFA VRTTGVFCRP SCRSKRALRK NVRFFANAQQ
70 80 90 100 110 120
ALDAGFRPCK RCQPDNARAQ QRRLDKIACA CRLLEQETPV TLAFLAQAVA MSPFHLHRLF
130 140 150 160 170 180
KASTGMTPKG WQQAWRARRL REALAKGEPI TAAIYRAGFP DSSSYYRHAD QTLGMTAKQF
190 200 210 220 230 240
RKGGDNVSVR YALTDWVYGR CLVAESERGI CAILPGDSDD ALLAELHTLF PSARHEPADA
250 260 270 280 290 300
LFQQRVRQVV AAINTRDVLL SLPLDIQGTA FQQQVWQALC AIPCGETVSY QQLAATIGKP
310 320 330 340 350
TAVRAVASAC GANKLAMVIP CHRVVRRDGA LSGYRWGVRR KAQLLKREAQ KEE
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P26189 in FASTA format |
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