ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P26046

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name ACVS2_PENCH
Primary accession number P26046
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on May 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Synonyms EC 6.3.2.26
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase
ACV synthetase
ACVS
Gene name
Name: PCBAB
From
Penicillium chrysogenum (Penicillium notatum) [TaxID: 5076] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Penicillium; Penicillium chrysogenum complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AS-P-78;
PubMed=2129535 [NCBI, ExPASy, EBI, Israel, Japan]
Diez B., Gutierrez S., Barredo J.L., van Solingen P., van der Voort L.H.M., Martin J.F.;
"The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.";
J. Biol. Chem. 265:16358-16365(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M57425; AAA63415.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A37886; YGPLV8.
3D structure databases
HSSP P14687; 1AMU. [HSSP ENTRY / PDB]
ModBase P26046.
Ontologies
GO
GO:0000036; Molecular function: acyl carrier activity (inferred from electronic annotation from InterPro).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds (inferred from electronic annotation from InterPro).
GO:0050564; Molecular function: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity (inferred from electronic annotation from EC).
GO:0031177; Molecular function: phosphopantetheine binding (inferred from electronic annotation from InterPro).
GO:0017000; Biological process: antibiotic biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010071; AA_adenyl_dom.
IPR009081; ACP_like.
IPR000873; AMP-dep_Synth/Lig.
IPR001242; Condensatn.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
IPR001031; Thioesterase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1200.10; ACP_like; 2.
Pfam PF00501; AMP-binding; 3.
PF00668; Condensation; 3.
PF00550; PP-binding; 3.
PF00975; Thioesterase; 1.
Pfam graphical view of domain structure.
PRINTS PR00154; AMPBINDING.
TIGRFAMs TIGR01733; AA-adenyl-dom; 3.
PROSITE PS50075; ACP_DOMAIN; 3.
PS00455; AMP_BINDING; 3.
PS00012; PHOSPHOPANTETHEINE; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS P26046.
ProtoNet P26046.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Antibiotic biosynthesis; Ligase; Multifunctional enzyme; Phosphopantetheine; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   3791  3791     N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase. PRO_0000193061
DOMAIN   853    924  72     Acyl carrier 1. 
DOMAIN   1939   2008  70     Acyl carrier 2. 
DOMAIN   3028   3095  68     Acyl carrier 3. 
REGION   307   1068  762     Domain 1 (adipate-activating). 
REGION   1392   2157  766     Domain 2 (cysteine-activating). 
REGION   2574   3242  669     Domain 3 (valine-activating). 
ACT_SITE   3631   3631        For thioesterase activity (By similarity). 
BINDING   885    885        Phosphopantetheine (covalent) (By similarity). 
BINDING   1971   1971        Phosphopantetheine (covalent) (By similarity). 
BINDING   3058   3058        Phosphopantetheine (covalent) (By similarity). 
Sequence information
Length: 3791 AA [This is the length of the unprocessed precursor] Molecular weight: 425922 Da [This is the MW of the unprocessed precursor] CRC64: 1B628000F8A00492 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTQLKPPNGT TPIGFSATTS LNASGSSSVK NGTIKPSNGI FKPSTRDTMD PCSGNAADGS 

        70         80         90        100        110        120 
IRVRFRGGIE RWKECVNQVP ERCDLSGLTT DSTRYQLAST GFGDASAAYQ ERLMTVPVDV 

       130        140        150        160        170        180 
HAALQELCLE RRVSVGSVIN FSVHQMLKGF GNGTHTITAS LHREQNLQNS SPSWVVSPTI 

       190        200        210        220        230        240 
VTHENRDGWS VAQAVESIEA GRGSEKESVT AIDSGSSLVK MGLFDLLVSF VDADDARIPC 

       250        260        270        280        290        300 
FDFPLAVIVR ECDANLSLTL RFSDCLFNEE TICNFTDALN ILLAEAVIGR VTPVADIELL 

       310        320        330        340        350        360 
SAEQKQQLEE WNNTDGEYPS SKRLHHLIEE VVERHEDKIA VVCDERELTY GELNAQGNSL 

       370        380        390        400        410        420 
ARYLRSIGIL PEQLVALFLD KSEKLIVTIL GVWKSGAAYV PIDPTYPDER VRFVLDDTKA 

       430        440        450        460        470        480 
RAIIASNQHV ERLQREVIGD RNLCIIRLEP LLASLAQDSS KFPAHNLDDL PLTSQQLAYV 

       490        500        510        520        530        540 
TYTSGTTGFP KGIFKQHTNV VNSITDLSAR YGVAGQHHEA ILLFSACVFE PFVRQTLMAL 

       550        560        570        580        590        600 
VNGHLLAVIN DVEKYDADTL LPFIRRHSIT YLNGTASVLQ EYDFSDCPSL NRIILVGENL 

       610        620        630        640        650        660 
TEARYLALRQ RFKNRILNEY GFTESAFVTA LKIFDPESTR KDTSLGRPVR NVKCYILNPS 

       670        680        690        700        710        720 
LKRVPIGATG ELHIGGLGIS KGYLNRPELT PHRFIPNPFQ TDCEKQLGIN SLMYKTGDLA 

       730        740        750        760        770        780 
RWLPNGEVEY LGRADFQIKL RGIRIEPGEI ETMLAMYPRV RTSLVVSKKL RNGPEETTNE 

       790        800        810        820        830        840 
HLVGYYVCDS ASVSEADLLS FLEKKLPRYM IPTRLVQLSQ IPVNVNGKAD LRALPAVDIS 

       850        860        870        880        890        900 
NSTEVRSDLR GDTEIALGEI WADVLGARQR SVSRNDNFFR LGGHSITCIQ LIARIRQRQR 

       910        920        930        940        950        960 
LSVSISVEDV FATRTLERMA DLLQNKQQEK CDKPHEAPTE LLEENAATDN IYLANSLQQG 

       970        980        990       1000       1010       1020 
FVYHYLKSME QSDAYVMQSV LRYNTTLSPD LFQRAWKHAQ QSFPALRLRF SWEKEVFQLL 

      1030       1040       1050       1060       1070       1080 
DQDPPLDWRF LYFTDVAAGA VEDRKLEDLR RQDLTERFKL DVGRLFRVYL IKHSENRFTC 

      1090       1100       1110       1120       1130       1140 
LFSCHHAILD GWSLPLLFEK VHETYLQLLH GDNLTSSMDD PYTRTQRYLH AHREDHLDFW 

      1150       1160       1170       1180       1190       1200 
AGVVQKINER CDMNALLNER SRYKVQLADY DQVQEQRQLT IALSGDAWLA DLRQTCSAQG 

      1210       1220       1230       1240       1250       1260 
ITLHSILQFV WHAVLHAYGG GTHTITGTTI SGRNLPILGI ERAVGPYINT LPLVLDHSTF 

      1270       1280       1290       1300       1310       1320 
KDKTIMEAIE DVQAKVNVMN SRGNVELGRL HKTDLKHGLF DSLFVLENYP NLDKSRTLEH 

      1330       1340       1350       1360       1370       1380 
QTELGYSIEG GTEKLNYPLA VIAREVETTG GFTVSICYAS ELFEEVMISE LLHMVQDTLM 

      1390       1400       1410       1420       1430       1440 
QVARGLNEPV GSLEYLSSIQ LEQLAAWNAT EAEFPDTTLH EMFENEASQK PDKIAVVYEE 

      1450       1460       1470       1480       1490       1500 
TSLTYRELNE RANRMAHQLR SDVSPNPNEV IALVMDKSEH MIVNILAVWK SGGAYVPIDP 

      1510       1520       1530       1540       1550       1560 
GYPNDRIQYI LEDTQALAVI ADSCYLPRIK GMAASGTLLY PSVLPANPDS KWSVSNPSPL 

      1570       1580       1590       1600       1610       1620 
SRSTDLAYII YTSGTTGRPK GVTVEHHGVV NLQVSLSKVF GLRDTDDEVI LSFSNYVFDH 

      1630       1640       1650       1660       1670       1680 
FVEQMTDAIL NGQTLLVLND GMRGDKERLY RYIEKNRVTY LSGTPSVVSM YEFSRFKDHL 

      1690       1700       1710       1720       1730       1740 
RRVDCVGEAF SEPVFDKIRE TFHGLVINGY GPTEVSITTH KRLYPFPERR MDKSIGQQVH 

      1750       1760       1770       1780       1790       1800 
NSTSYVLNED MKRTPIGAVG ELYLGGEGVV RGYHNRADVT AERFIPNPFQ SEEDKREGRN 

      1810       1820       1830       1840       1850       1860 
SRLYKTGDLV RWIPGSSGEV EYLGRNDFQV KIRGLRIELG EIEAILSSYH GIKQSVVIAK 

      1870       1880       1890       1900       1910       1920 
DCREGAQKFL VGYYVADAAL PSAAIRRFMQ SRLPGYMVPS RLILVSKFPV TPSGKLDTKA 

      1930       1940       1950       1960       1970       1980 
LPPAEEESEI DVVPPRSEIE RSLCDIWAEL LEMHPEEIGI YSDFFSLGGD SLKSTKLSFM 

      1990       2000       2010       2020       2030       2040 
IHESFNRAVS VSALFCHRTV EAQTHLILND AADVHEITPI DCNDTQMIPV SRAQERLLFI 

      2050       2060       2070       2080       2090       2100 
HEFENGSNAY NIDAAFELPG SVDASLLEQA LRGNLARHEA LRTLLVKDHA TGIYLQKVLS 

      2110       2120       2130       2140       2150       2160 
PDEAQGMFSV NVDTAKQVER LDQEIASLSQ HVFRLDDELP WEARILKLES GGLYLILAFH 

      2170       2180       2190       2200       2210       2220 
HTCFDAWSLK VFEQELRALY AALQKTKSAA NLPALKAQYK EYALYHRRQL SGDRMRNLSD 

      2230       2240       2250       2260       2270       2280 
FWLRKLIGLE PLQLITDRPR PVQFKYDGDD LSIELSKKET ENLRGVAKRC KSSLYVVLVS 

      2290       2300       2310       2320       2330       2340 
VYCVMLASYA NQSDVSVGIP VSHRTHPQFQ SVIGFFVNLV VLRVDISQSA ICGLIRRVMK 

      2350       2360       2370       2380       2390       2400 
ELVDAQLHQD MPFQEVTKLL QVDNDPSRHP LVQNVFNFES RANGEHDARS EDEGSLAFNQ 

      2410       2420       2430       2440       2450       2460 
YRPVQPVDSV AKFDLNATVT ELESGLRVNF NYATSLFNKS TIQGFLHTYE YLLRQLSELS 

      2470       2480       2490       2500       2510       2520 
AEGINEDTQL SLVRPTENGD LHLPLAQSPL ATTAEEQKVA SLNQAFEREA FLAAEKIAVV 

      2530       2540       2550       2560       2570       2580 
QGDRALSYAD LNGQANQLAR YIQSVSCIGA DDGIALMLEK SIDTIICILA IWKAGAAYVP 

      2590       2600       2610       2620       2630       2640 
LDPTYPPGRV QLILEEIKAK AVLVHSSHAS KCERHGAKVI AVDSPAIETA VSQQSAADLP 

      2650       2660       2670       2680       2690       2700 
TIASLGNLAY IIFTSGTSGK PKGVLVEQKA VLLLRDALRE RYFGRDCTKH HGVLFLSNYV 

      2710       2720       2730       2740       2750       2760 
FDFSVEQLVL SVLSGHKLIV PPAEFVADDE FYRMASTHGL SYLSGTPSLL QKIDLARLDH 

      2770       2780       2790       2800       2810       2820 
LQVVTAAGEE LHATQYEKMR RRFNGPIYNA YGVTETTVYN IIAEFTTNSI FENALREVLP 

      2830       2840       2850       2860       2870       2880 
GTRAYVLNAA LQPVPFDAVG ELYLAGDSVT RGYLNQPLLT DQRFIPNPFC KEEDIAMGRF 

      2890       2900       2910       2920       2930       2940 
ARLYKTGDLV RSRFNRQQQP QLEYLGRGDL QIKMRGYRIE ISEVQNVLTS SPGVREGAVV 

      2950       2960       2970       2980       2990       3000 
AKYENNDTYS RTAHSLVGYY TTDNETVSEA DILTFMKARL PTYMVPSHLC CLEGALPVTI 

      3010       3020       3030       3040       3050       3060 
NGKLDVRRLP EIINDSAQSS YSPPRNIIEA KMCRLWESAL GMERCGIDDD LFKLGGDSIT 

      3070       3080       3090       3100       3110       3120 
SLHLVAQIHN QVGCKITVRD IFEHRTARAL HDHVFMKDSD RSNVTQFRTE QGPVIGEAPL 

      3130       3140       3150       3160       3170       3180 
LPIQDWFLSK ALQHPMYWNH TFYVRTPELD VDSLSAAVRD LQQYHDVFRM RLKREEVGFV 

      3190       3200       3210       3220       3230       3240 
QSFAEDFSPA QLRVLNVKDV DGSAAVNEIL DGWQSGFNLE NGPIGSIGYL HGYEDRSARV 

      3250       3260       3270       3280       3290       3300 
WFSVHHMAID TVSWQILVRD LQTLYRNGSL GSKGSSFRQW AEAIQNYKAS DSERNHWNKL 

      3310       3320       3330       3340       3350       3360 
VMETASSISA LPTSTGSRVR LSRSLSPEKT ASLIQGGIDR QDVSVYDSLL TSVGLALQHI 

      3370       3380       3390       3400       3410       3420 
APTGPSMVTI EGHGREEVDQ TLDVSRTMGW FTTMYPFEIP RLSTENIVQG VVAVSERFRQ 

      3430       3440       3450       3460       3470       3480 
VPARGVGYGT LYGYTQHPLP QVTVNYLGQL ARKQSKPKEW VLAVGDNEFE YGLMTSPEDK 

      3490       3500       3510       3520       3530       3540 
DRSSSAVDVT AVCIDGTMII DVDSAWSLEE SEQFISSIEE GLNKILDGRA SQQTSRFPDV 

      3550       3560       3570       3580       3590       3600 
PQPAETYTPY FEYLEPPRQG PTLFLLPPGE GGAESYFNNI VKRLRQTNMV VFNNYYLHSK 

      3610       3620       3630       3640       3650       3660 
RLRTFEELAE MYLDQVRGIQ PHGPYHFIGW SFGGILAMEM SRRLVASDEK IGFLGIIDTY 

      3670       3680       3690       3700       3710       3720 
FNVRGATRTI GLGDTEILDP IHHIYNPDPA NFQRLPSATD RIVLFKAMRP NNKYESENQR 

      3730       3740       3750       3760       3770       3780 
RLYEYYDALD STDWTACYQA IPTSSWSRLR TIHTFPGSEI HNRWSRCVRL SRNTSLAIDP 

      3790 
SLAAQYIGRW K
P26046 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by au flag APAF Australia Mirror sites: Brazil Canada China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!