[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Monocyte;
DOI=10.1016/0092-8674(91)90022-Q; PubMed=1829648 [NCBI, ExPASy, EBI, Israel, Japan]
Haskill S.,
Beg A.A.,
Tompkins S.M.,
Morris J.S.,
Yurochko A.D.,
Sampson-Johannes A.,
Mondal K.,
Ralph P.,
Baldwin A.S. Jr.;
"Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.";
Cell 65:1281-1289(1991).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Lymph node;
DOI=10.1084/jem.191.2.395; PubMed=10637284 [NCBI, ExPASy, EBI, Israel, Japan]
Jungnickel B.,
Staratschek-Jox A.,
Braeuninger A.,
Spieker T.,
Wolf J.,
Diehl V.,
Hansmann M.-L.,
Rajewsky K.,
Kueppers R.;
"Clonal deleterious mutations in the IkappaB alpha gene in the malignant cells in Hodgkin's lymphoma.";
J. Exp. Med. 191:395-402(2000).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
Liu B.,
Huang A.;
"Homo sapiens IkBa mRNA.";
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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INTERACTION WITH RELA.
PubMed=1493333 [NCBI, ExPASy, EBI, Israel, Japan]
Ganchi P.A.,
Sun S.C.,
Greene W.C.,
Ballard D.W.;
"I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding.";
Mol. Biol. Cell 3:1339-1352(1992).
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[8]
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UBIQUITINATION AT LYS-21 AND LYS-22, FUNCTION, AND MUTAGENESIS OF LYS-21; LYS-22; LYS-38 AND LYS-47.
DOI=10.1073/pnas.92.24.11259; PubMed=7479976 [NCBI, ExPASy, EBI, Israel, Japan]
Scherer D.C.,
Brockman J.A.,
Chen Z.,
Maniatis T.,
Ballard D.W.;
"Signal-induced degradation of IkappaB alpha requires site-specific ubiquitination.";
Proc. Natl. Acad. Sci. U.S.A. 92:11259-11263(1995).
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[9]
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PHOSPHORYLATION AT TYR-42, AND MUTAGENESIS OF TYR-42.
DOI=10.1016/S0092-8674(00)80153-1; PubMed=8797825 [NCBI, ExPASy, EBI, Israel, Japan]
Imbert V.,
Rupec R.A.,
Livolsi A.,
Pahl H.L.,
Traenckner E.B.-M.,
Mueller-Dieckmann C.,
Farahifar D.,
Rossi B.,
Auberger P.,
Baeuerle P.A.,
Peyron J.-F.;
"Tyrosine phosphorylation of IkappaB-alpha activates NF-kappaB without proteolytic degradation of IkappaB-alpha.";
Cell 86:787-798(1996).
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[10]
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PHOSPHORYLATION AT SER-283; SER-288; SER-293 AND THR-291.
PubMed=8622692 [NCBI, ExPASy, EBI, Israel, Japan]
McElhinny J.A.,
Trushin S.A.,
Bren G.D.,
Chester N.,
Paya C.V.;
"Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation.";
Mol. Cell. Biol. 16:899-906(1996).
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[11]
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MUTAGENESIS OF LYS-21; LYS-22; ASP-31; SER-32; ASP-35; SER-36; SER-234; SER-262 AND THR-263.
PubMed=8657102 [NCBI, ExPASy, EBI, Israel, Japan]
DiDonato J.A.,
Mercurio F.,
Rosette C.,
Wu-Li J.,
Suyang H.,
Ghosh S.,
Karin M.;
"Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.";
Mol. Cell. Biol. 16:1295-1304(1996).
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[12]
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PHOSPHORYLATION AT THR-291; SER-283 AND THR-299.
PubMed=8657113 [NCBI, ExPASy, EBI, Israel, Japan]
Lin R.,
Beauparlant P.,
Makris C.,
Meloche S.,
Hiscott J.;
"Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.";
Mol. Cell. Biol. 16:1401-1409(1996).
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[13]
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SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, AND MUTAGENESIS OF 115-LEU--ILE-120.
PubMed=9566872 [NCBI, ExPASy, EBI, Israel, Japan]
Sachdev S.,
Hoffmann A.,
Hannink M.;
"Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences.";
Mol. Cell. Biol. 18:2524-2534(1998).
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[14]
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INTERACTION WITH HBV PROTEIN X.
PubMed=10454581 [NCBI, ExPASy, EBI, Israel, Japan]
Weil R.,
Sirma H.,
Giannini C.,
Kremsdorf D.,
Bessia C.,
Dargemont C.,
Brechot C.,
Israel A.;
"Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.";
Mol. Cell. Biol. 19:6345-6354(1999).
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[15]
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PHOSPHORYLATION AT SER-32 AND SER-36.
DOI=10.1016/S1097-2765(00)80445-1; PubMed=10882136 [NCBI, ExPASy, EBI, Israel, Japan]
Peters R.T.,
Liao S.-M.,
Maniatis T.;
"IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex.";
Mol. Cell 5:513-522(2000).
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[16]
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INTERACTION WITH NKIRAS1 AND NKIRAS2.
DOI=10.1126/science.287.5454.869; PubMed=10657303 [NCBI, ExPASy, EBI, Israel, Japan]
Fenwick C.,
Na S.-Y.,
Voll R.E.,
Zhong H.,
Im S.-Y.,
Lee J.W.,
Ghosh S.;
"A subclass of Ras proteins that regulate the degradation of IkappaB.";
Science 287:869-873(2000).
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[17]
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SUBCELLUAR LOCATION, NUCLEAR EXPORT SIGNAL, AND MUTAGENESIS OF 45-MET--ILE-52.
DOI=10.1073/pnas.97.3.1014; PubMed=10655476 [NCBI, ExPASy, EBI, Israel, Japan]
Huang T.T.,
Kudo N.,
Yoshida M.,
Miyamoto S.;
"A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes.";
Proc. Natl. Acad. Sci. U.S.A. 97:1014-1019(2000).
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[18]
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SUMOYLATION AT LYS-21, SUBCELLULAR LOCATION, AND MUTAGENESIS OF LYS-21 AND LYS-22.
DOI=10.1074/jbc.M009476200; PubMed=11124955 [NCBI, ExPASy, EBI, Israel, Japan]
Rodriguez M.S.,
Dargemont C.,
Hay R.T.;
"SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.";
J. Biol. Chem. 276:12654-12659(2001).
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[19]
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INTERACTION WITH RWDD3, SUMOYLATION, AND MUTAGENESIS OF LYS-21 AND LSY-22.
DOI=10.1016/j.cell.2007.07.044; PubMed=17956732 [NCBI, ExPASy, EBI, Israel, Japan]
Carbia-Nagashima A.,
Gerez J.,
Perez-Castro C.,
Paez-Pereda M.,
Silberstein S.,
Stalla G.K.,
Holsboer F.,
Arzt E.;
"RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.";
Cell 131:309-323(2007).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 70-282.
DOI=10.1016/S0092-8674(00)81698-0; PubMed=9865693 [NCBI, ExPASy, EBI, Israel, Japan]
Jacobs M.D.,
Harrison S.C.;
"Structure of an IkappaBalpha/NF-kappaB complex.";
Cell 95:749-758(1998).
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[21]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 73-302.
DOI=10.1016/S0092-8674(00)81699-2; PubMed=9865694 [NCBI, ExPASy, EBI, Israel, Japan]
Huxford T.,
Huang D.B.,
Malek S.,
Ghosh G.;
"The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.";
Cell 95:759-770(1998).
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[22]
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VARIANT ADEDAID ILE-32.
DOI=10.1172/JCI200318714; PubMed=14523047 [NCBI, ExPASy, EBI, Israel, Japan]
Courtois G.,
Smahi A.,
Reichenbach J.,
Doffinger R.,
Cancrini C.,
Bonnet M.,
Puel A.,
Chable-Bessia C.,
Yamaoka S.,
Feinberg J.,
Dupuis-Girod S.,
Bodemer C.,
Livadiotti S.,
Novelli F.,
Rossi P.,
Fischer A.,
Israel A.,
Munnich A.,
Le Deist F.,
Casanova J.L.;
"A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.";
J. Clin. Invest. 112:1108-1115(2003).
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[23]
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INVOLVEMENT IN ADEDAID.
DOI=10.1002/humu.20740; PubMed=18412279 [NCBI, ExPASy, EBI, Israel, Japan]
Lopez-Granados E.,
Keenan J.E.,
Kinney M.C.,
Leo H.,
Jain N.,
Ma C.A.,
Quinones R.,
Gelfand E.W.,
Jain A.;
"A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency.";
Hum. Mutat. 29:861-868(2008).
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