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UniProtKB/Swiss-Prot entry P25783


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CATV_NPVAC
Primary accession number P25783
Secondary accession number Q96589
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on May 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Viral cathepsin [Precursor]
Synonyms V-cath
EC 3.4.22.50
Cysteine proteinase
CP
Gene name
Name: VCATH
From
Autographa californica nuclear polyhedrosis virus (AcMNPV) [TaxID: 46015] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Baculoviridae; Alphabaculovirus.
Virus host Lepidoptera (butterflies and moths) [TaxID: 7088]
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C6;
Kuzio J., Faulkner P.;
"Identification of a cysteine proteinase encoded by the Autographa californica nuclear polyhedrosis virus.";
(In) Goosen M.F.A., Daugulis A.J., Faulkner P. (eds.); Insect cell culture engineering, pp.17-50, Marcel Dekker, New York (1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C6;
DOI=10.1006/viro.1994.1380; PubMed=8030224 [NCBI, ExPASy, EBI, Israel, Japan]
Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
"The complete DNA sequence of Autographa californica nuclear polyhedrosis virus.";
Virology 202:586-605(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-323.
PubMed=1363350 [NCBI, ExPASy, EBI, Israel, Japan]
Rawlings N.D., Pearl L.H., Buttle D.J.;
"The baculovirus Autographa californica nuclear polyhedrosis virus genome includes a papain-like sequence.";
Biol. Chem. Hoppe-Seyler 373:1211-1215(1992).
[4]
CHARACTERIZATION.
PubMed=8590630 [NCBI, ExPASy, EBI, Israel, Japan]
Bromme D., Okamoto K.;
"The baculovirus cysteine protease has a cathepsin B-like S2-subsite specificity.";
Biol. Chem. Hoppe-Seyler 376:611-615(1995).
[5]
CHARACTERIZATION.
PubMed=7730794 [NCBI, ExPASy, EBI, Israel, Japan]
Slack J.M., Kuzio J., Faulkner P.;
"Characterization of v-cath, a cathepsin L-like proteinase expressed by the baculovirus Autographa californica multiple nuclear polyhedrosis virus.";
J. Gen. Virol. 76:1091-1098(1995).
[6]
PROTEOLYTIC CLEAVAGE.
DOI=10.1006/viro.2002.1378; PubMed=12069520 [NCBI, ExPASy, EBI, Israel, Japan]
Hom L.G., Ohkawa T., Trudeau D., Volkman L.E.;
"Autographa californica M nucleopolyhedrovirus ProV-CATH is activated during infected cell death.";
Virology 296:212-218(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M67451; AAA46752.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L22858; AAA66757.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X70124; CAA49713.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S62736; S62736.
RefSeq NP_054157.1; -.
3D structure databases
HSSP P53634; 1K3B. [HSSP ENTRY / PDB]
ModBase P25783.
Protein family/group databases
MEROPS C01.083; -.
Ontologies
GO
GO:0004197; Molecular function: cysteine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000169; Pept_cys_AS.
IPR013128; Peptidase_C1A.
IPR000668; Peptidase_C1A_C.
IPR013201; Prot_inhib_I29.
Graphical view of domain structure.
PANTHER PTHR12411; Peptidase_C1A; 1.
Pfam PF08246; Inhibitor_I29; 1.
PF00112; Peptidase_C1; 1.
Pfam graphical view of domain structure.
PRINTS PR00705; PAPAIN.
ProDom PD000158; Peptidase_C1; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00645; Pept_C1; 1.
SMART graphical view of domain structure.
PROSITE PS00640; THIOL_PROTEASE_ASN; 1.
PS00139; THIOL_PROTEASE_CYS; 1.
PS00639; THIOL_PROTEASE_HIS; 1.
BLOCKS P25783.
ProtoNet P25783.
Genome annotation databases
GeneID 1403960; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Hydrolase; Protease; Signal; Thiol protease; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
PROPEP   17   112  96     Activation peptide (Potential). PRO_0000322201
CHAIN   113   323  211     Viral cathepsin. PRO_0000050572
ACT_SITE   136   136        By similarity. 
ACT_SITE   269   269        By similarity. 
ACT_SITE   289   289        By similarity. 
CARBOHYD   158   158        N-linked (GlcNAc...) (Potential). 
DISULFID   133   174        By similarity. 
DISULFID   167   207        By similarity. 
DISULFID   262   310        By similarity. 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 36938 Da [This is the MW of the unprocessed precursor] CRC64: F23876A6ED303FC8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNKILFYLFV YGVVNSAAYD LLKAPNYFEE FVHRFNKDYG SEVEKLRRFK IFQHNLNEII 

        70         80         90        100        110        120 
NKNQNDSAKY EINKFSDLSK DETIAKYTGL SLPIQTQNFC KVIVLDQPPG KGPLEFDWRR 

       130        140        150        160        170        180 
LNKVTSVKNQ GMCGACWAFA TLASLESQFA IKHNQLINLS EQQMIDCDFV DAGCNGGLLH 

       190        200        210        220        230        240 
TAFEAIIKMG GVQLESDYPY EADNNNCRMN SNKFLVQVKD CYRYITVYEE KLKDLLRLVG 

       250        260        270        280        290        300 
PIPMAIDAAD IVNYKQGIIK YCFNSGLNHA VLLVGYGVEN NIPYWTFKNT WGTDWGEDGF 

       310        320 
FRVQQNINAC GMRNELASTA VIY 

P25783 in FASTA format

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