[1]	NUCLEOTIDE SEQUENCE [MRNA] (EUR M 1.0101 AND EUR M 1.0102). DOI=10.1159/000024026; PubMed=9925958 [NCBI, ExPASy, EBI, Israel, Japan] Smith W., Mills K., Hazell L., Hart B.J., Thomas W.; "Molecular analysis of the group 1 and 2 allergens from the house dust mite, Euroglyphus maynei."; Int. Arch. Allergy Immunol. 118:15-22(1999).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-309. PubMed=1483062 [NCBI, ExPASy, EBI, Israel, Japan] Kent N.A., Hill M.R., Keen J.N., Holland P.W., Hart B.J.; "Molecular characterisation of group I allergen Eur m I from house dust mite Euroglyphus maynei."; Int. Arch. Allergy Immunol. 99:150-152(1992).

Comments

FUNCTION: Probable thiol protease.
CATALYTIC ACTIVITY: Broad endopeptidase specificity.
SUBCELLULAR LOCATION: Secreted.
ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
SIMILARITY: Belongs to the peptidase C1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF047610; AAC82351.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF047611; AAC82352.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF047612; AAC82353.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60073; CAA42677.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S21864; S21864.

3D structure databases

HSSP

P53634; 1K3B. [HSSP ENTRY / PDB]

SMR

P25780; 22-321.

ModBase

P25780.

Protein family/group databases

MEROPS

C01.073; -.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004197;	Molecular function: cysteine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006508;	Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000169; Pept_cys_AS.
IPR013128; Peptidase_C1A.
IPR000668; Peptidase_C1A_C.
IPR013201; Prot_inhib_I29.
Graphical view of domain structure.

PANTHER

PTHR12411; Peptidase_C1A; 1.

Pfam

PF08246; Inhibitor_I29; 1.
PF00112; Peptidase_C1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00705; PAPAIN.

ProDom

PD000158; Peptidase_C1; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00645; Pept_C1; 1.
SMART graphical view of domain structure.

PROSITE

PS00640; THIOL_PROTEASE_ASN; 1.
PS00139; THIOL_PROTEASE_CYS; 1.
PS00639; THIOL_PROTEASE_HIS; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allergen; Glycoprotein; Hydrolase; Protease; Secreted; Signal; Thiol protease; Zymogen.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`PROPEP`	`19 98`	`80`		`PRO_0000026378`
`CHAIN`	`99 321`	`223`	`Peptidase 1.`	`PRO_0000026379`
`ACT_SITE`	`133 133`		`By similarity.`
`ACT_SITE`	`269 269`		`By similarity.`
`ACT_SITE`	`289 289`		`By similarity.`
`CARBOHYD`	`34 34`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`151 151`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`130 170`		`By similarity.`
`VARIANT`	`36 36`	`1`	`T -> S (in Eur m 1.0102).`
`VARIANT`	`126 126`	`1`	`M -> N (in Eur m 1.0102).`
`VARIANT`	`320 320`	`1`	`M -> I (in Eur m 1.0102).`

Sequence information

Length: 321 AA [This is the length of the unprocessed precursor]

Molecular weight: 36290 Da [This is the MW of the unprocessed precursor]

CRC64: 6CFD44FEC725999E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKIILAIASL LVLSAVYARP ASIKTFEEFK KAFNKTYATP EKEEVARKNF LESLKYVESN 

        70         80         90        100        110        120 
KGAINHLSDL SLDEFKNQFL MNANAFEQLK TQFDLNAETY ACSINSVSLP SELDLRSLRT 

       130        140        150        160        170        180 
VTPIRMQGGC GSCWAFSGVA STESAYLAYR NMSLDLAEQE LVDCASQNGC HGDTIPRGIE 

       190        200        210        220        230        240 
YIQQNGVVQE HYYPYVAREQ SCHRPNAQRY GLKNYCQISP PDSNKIRQAL TQTHTAVAVI 

       250        260        270        280        290        300 
IGIKDLNAFR HYDGRTIMQH DNGYQPNYHA VNIVGYGNTQ GVDYWIVRNS WDTTWGDNGY 

       310        320 
GYFAANINLM MIEQYPYVVM L

P25780 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools