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UniProtKB/Swiss-Prot entry P25686


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNJB2_HUMAN
Primary accession number P25686
Secondary accession numbers A8K9P6 Q8IUK1 Q8IUK2 Q96F52
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on September 11, 2007 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 86)
Name and origin of the protein
Protein name DnaJ homolog subfamily B member 2
Synonyms Heat shock 40 kDa protein 3
DnaJ protein homolog 1
HSJ-1
Gene name
Name: DNAJB2
Synonyms: HSJ1, HSPF3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=1599432 [NCBI, ExPASy, EBI, Israel, Japan]
Cheetham M.E., Brion J.-P., Anderton B.H.;
"Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.";
Biochem. J. 284:469-476(1992).
[2]
SEQUENCE REVISION TO 214.
Cheetham M.E.;
Submitted (JUL-1998) to UniProtKB.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Lung;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
TISSUE=Colon, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
DOI=10.1186/gb-2004-5-2-r8; PubMed=14759258 [NCBI, ExPASy, EBI, Israel, Japan]
Hillman R.T., Green R.E., Brenner S.E.;
"An unappreciated role for RNA surveillance.";
Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S37375; AAA09034.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S37374; AAA09035.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X63368; CAA44968.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X63368; CAA44969.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007088; AAP35751.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK292761; BAF85450.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011609; AAH11609.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC047056; AAH47056.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00220102; -.
IPI00874105; -.
PIR S23508; S23508.
RefSeq NP_001034639.1; -.
NP_006727.2; -.
UniGene Hs.77768
3D structure databases
HSSP P25685; 1HDJ. [HSSP ENTRY / PDB]
SMR P25686; 1-69.
ModBase P25686.
Protein-protein interaction databases
DIP DIP:29051N; -.
PTM databases
PhosphoSite P25686; -.
Organism-specific databases
GeneCards GC02P219852; -.
H-InvDB HIX0002859; -.
HGNC HGNC:5228; DNAJB2.
GenAtlas DNAJB2.
MIM 604139; gene. [NCBI / EBI]
PharmGKB PA27415; -.
Gene expression databases
ArrayExpress P25686; -.
Bgee P25686; -.
CleanEx HS_DNAJB2; -.
GermOnline ENSG00000135924; Homo sapiens.
Ontologies
GO
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082; Molecular function: unfolded protein binding (traceable author statement from ProtInc).
GO:0006457; Biological process: protein folding (traceable author statement from ProtInc).
GO:0006986; Biological process: response to unfolded protein (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003903; Ubiquitin-int_motif.
Graphical view of domain structure.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
PF02809; UIM; 1.
Pfam graphical view of domain structure.
SMART SM00271; DnaJ; 1.
SM00726; UIM; 2.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; 1.
PS50076; DNAJ_2; 1.
PS50330; UIM; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P25686; -.
Genome annotation databases
Ensembl ENSG00000135924; Homo sapiens. [Contig view]
GeneID 3300; -.
KEGG hsa:3300; -.
Phylogenomic databases
HOGENOM P25686; -.
HOVERGEN P25686; -.
OMA P25686; QQSVTSR.
Other
NextBio 13093; -.
SOURCE DNAJB2; Homo sapiens.
ProtoNet P25686.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Chaperone; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   324  324     DnaJ homolog subfamily B member 2. PRO_0000071018
DOMAIN   1    71  71     J. 
REPEAT   210   226  17     UIM 1. 
REPEAT   250   269  20     UIM 2. 
VAR_SEQ   275   277        GGR -> DVF (in isoform 2). VSP_001286
VAR_SEQ   278   324        Missing (in isoform 2). VSP_001287
VARIANT   270   270  1     G -> R (in dbSNP:rs34127289 [NCBI]). VAR_048910 
CONFLICT   214   214        L -> R (in Ref. 1; AAA09034/AAA09035). 
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 35580 Da [This is the MW of the unprocessed precursor] CRC64: 0154ED3E29F34B4A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MASYYEILDV PRSASADDIK KAYRRKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 

        70         80         90        100        110        120 
KREIYDRYGR EGLTGTGTGP SRAEAGSGGP GFTFTFRSPE EVFREFFGSG DPFAELFDDL 

       130        140        150        160        170        180 
GPFSELQNRG SRHSGPFFTF SSSFPGHSDF SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT 

       190        200        210        220        230        240 
TRRIMENGQE RVEVEEDGQL KSVTINGVPD DLALGLELSR REQQPSVTSR SGGTQVQQTP 

       250        260        270        280        290        300 
ASCPLDSDLS EDEDLQLAMA YSLSEMEAAG KKPAGGREAQ HRRQGRPKAQ HQDPGLGGTQ 

       310        320 
EGARGEATKR SPSPEEKASR CLIL 

P25686 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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