[1]	PROTEIN SEQUENCE. PubMed=8612630 [NCBI, ExPASy, EBI, Israel, Japan] Hjelmqvist L., Shafqat J., Siddiqi A.R., Joernvall H.; "Linking of isozyme and class variability patterns in the emergence of novel alcohol dehydrogenase functions. Characterization of isozymes in Uromastix hardwickii."; Eur. J. Biochem. 236:563-570(1996).
[2]	PROTEIN SEQUENCE OF 1-18. TISSUE=Liver; DOI=10.1016/0014-5793(92)80080-Z; PubMed=1544464 [NCBI, ExPASy, EBI, Israel, Japan] Hjelmqvist L., Ericsson M., Shafqat J., Carlquist M., Siddiqi A.R., Hoeoeg J.-O., Joernvall H.; "Reptilian alcohol dehydrogenase. Heterogeneity relevant to class multiplicity of the mammalian enzyme."; FEBS Lett. 298:297-300(1992).

Comments

CATALYTIC ACTIVITY: An alcohol + NAD⁺ = an aldehyde or ketone + NADH.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBUNIT: Multimeric (with different ratios of monomers).
SUBCELLULAR LOCATION: Cytoplasm.
MISCELLANEOUS: In U.hardwickii there are two isozymes of alcohol dehydrogenase I.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

S62638; S62638.

3D structure databases

HSSP

P00328; 1EE2. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

P25405; 2-375.

ModBase

P25405.

Ontologies

GO:0004022;	Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

BLOCKS

P25405.

Phylogenomic databases

HOVERGEN

P25405; -.

Other

ProtoNet

P25405.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Cytoplasm; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 375`	`375`	`Alcohol dehydrogenase 1A.`	`PRO_0000160677`
`METAL`	`46 46`		`Zinc 1 (catalytic) (By similarity).`
`METAL`	`67 67`		`Zinc 1 (catalytic) (By similarity).`
`METAL`	`97 97`		`Zinc 2 (By similarity).`
`METAL`	`100 100`		`Zinc 2 (By similarity).`
`METAL`	`103 103`		`Zinc 2 (By similarity).`
`METAL`	`111 111`		`Zinc 2 (By similarity).`
`METAL`	`174 174`		`Zinc 1 (catalytic) (By similarity).`
`MOD_RES`	`1 1`		`N-acetylglycine.`

Sequence information

Length: 375 AA [This is the length of the unprocessed precursor]

Molecular weight: 39663 Da [This is the MW of the unprocessed precursor]

CRC64: F315BB777996D906 [This is a checksum on the sequence]

        10         20         30         40         50         60 
GTAGKVIKCK AAIAWEIKKP LSIEQIEVAP PKAHEVRIKI LATGICRSDD HVISGAFKMP 

        70         80         90        100        110        120 
LPMVLGHEAA GVVESVGEGV TCVKPGDKVI PLFVPQCGKC SSCRSTRGNL CTSNDLSAAT 

       130        140        150        160        170        180 
GLMPDGTSRF TCKGKSLHHF ISTSSFTEYT VVHENSVVKI DAAAPLEKVC LIGCGFSTGY 

       190        200        210        220        230        240 
GAAVETAKVE PGSTCAVFGL GGVGLSAVMG CKAAGASRII GVDINKDKFP KAKEMGATEC 

       250        260        270        280        290        300 
VNPLDYKKPI NEVLFDLTGG EGVDYSFEVI GRTDTMTAAL ASCHMDYGTS IIVGLPPSAS 

       310        320        330        340        350        360 
EITFSPGLIF TGRTWKGSVF GGWKSKDSVP RLVSDFMQKK FSLDPLITHT MPFDKINEGF 

       370 
ELLRAGKSIR SVLLF

P25405 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools