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UniProtKB/Swiss-Prot entry P25332


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RBSK_YEAST
Primary accession number P25332
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on March 15, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 74)
Name and origin of the protein
Protein name Probable ribokinase
Synonym EC 2.7.1.15
Gene name
Name: RBK1
OrderedLocusNames: YCR036W
ORFNames: YCR36W, YCR523
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=1964349 [NCBI, ExPASy, EBI, Israel, Japan]
Thierry A., Fairhead C., Dujon B.;
"The complete sequence of the 8.2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase.";
Yeast 6:521-534(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1038/357038a0; PubMed=1574125 [NCBI, ExPASy, EBI, Israel, Japan]
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
"The complete DNA sequence of yeast chromosome III.";
Nature 357:38-46(1992).
[3]
SEQUENCE REVISION TO 178 AND 301.
Valles G., Volckaerts G.;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[4]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02026; PubMed=14562095 [NCBI, ExPASy, EBI, Israel, Japan]
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[5]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X56909; CAA40228.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X59720; CAA42303.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S12918; KIBYRB.
RefSeq NP_009965.2; -.
3D structure databases
HSSP Q9TVW2; 1LIO. [HSSP ENTRY / PDB]
ModBase P25332.
Protein-protein interaction databases
DIP DIP:4990N; -.
IntAct P25332; -.
Organism-specific databases
CYGD YCR036w; -.
SGD S000000632; RBK1.
Yeast-GFP YCR036W.
Gene expression databases
ArrayExpress P25332; -.
GermOnline YCR036W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004747; Molecular function: ribokinase activity (inferred from electronic annotation from InterPro).
GO:0006014; Biological process: D-ribose metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR011611; Carb/pur_kinase.
IPR002173; Carboh/pur_kinase_PfkB_CS.
IPR002139; Ribokinase.
Graphical view of domain structure.
Pfam PF00294; PfkB; 1.
Pfam graphical view of domain structure.
PRINTS PR00990; RIBOKINASE.
PROSITE PS00583; PFKB_KINASES_1; FALSE_NEG.
PS00584; PFKB_KINASES_2; 1.
BLOCKS P25332.
ProtoNet P25332.
Proteomic databases
PeptideAtlas P25332; -.
Genome annotation databases
Ensembl YCR036W; Saccharomyces cerevisiae. [Contig view]
GeneID 850402; -.
GenomeReviews X59720_GR; YCR036W.
KEGG sce:YCR036W; -.
NMPDR fig|4932.3.peg.690; -.
Phylogenomic databases
HOGENOM P25332; -.
Other
LinkHub P25332; -.
NextBio 965941; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Cytoplasm; Kinase; Nucleus; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   333  333     Probable ribokinase. PRO_0000080094
CONFLICT   178   178        A -> T (in Ref. 1; CAA40228). 
CONFLICT   301   301        T -> M (in Ref. 1; CAA40228). 
Sequence information
Length: 333 AA [This is the length of the unprocessed precursor] Molecular weight: 36924 Da [This is the MW of the unprocessed precursor] CRC64: 226B44DA7E458B95 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGITVIGSLN YDLDTFTDRL PNAGETFRAN HFETHAGGKG LNQAAAIGKL KNPSSRYSVR 

        70         80         90        100        110        120 
MIGNVGNDTF GKQLKDTLSD CGVDITHVGT YEGINTGTAT ILIEEKAGGQ NRILIVEGAN 

       130        140        150        160        170        180 
SKTIYDPKQL CEIFPEGKEE EEYVVFQHEI PDPLSIIKWI HANRPNFQIV YNPSPFKAMP 

       190        200        210        220        230        240 
KKDWELVDLL VVNEIEGLQI VESVFDNELV EEIREKIKDD FLGEYRKICE LLYEKLMNRK 

       250        260        270        280        290        300 
KRGIVVMTLG SRGVLFCSHE SPEVQFLPAI QNVSVVDTTG AGDTFLGGLV TQLYQGETLS 

       310        320        330 
TAIKFSTLAS SLTIQRKGAA ESMPLYKDVQ KDA 

P25332 in FASTA format

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