ID RCC1_DROME Reviewed; 547 AA. AC P25171; A4V1J1; Q9VRR5; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 2. DT 25-NOV-2008, entry version 80. DE RecName: Full=Regulator of chromosome condensation; DE AltName: Full=Chromatin-binding protein Bj1; GN Name=Bj1; ORFNames=CG10480; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=91216118; PubMed=2022188; RA Frasch M.; RT "The maternally expressed Drosophila gene encoding the chromatin- RT binding protein BJ1 is a homolog of the vertebrate gene Regulator of RT Chromatin Condensation, RCC1."; RL EMBO J. 10:1225-1236(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Berkeley; TISSUE=Embryo; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [5] RP CHARACTERIZATION, AND SUBCELLULAR LOCATION. RX MEDLINE=91216122; PubMed=2022190; RA Ohtsubo M., Yoshida T., Seino H., Nishitani H., Clark K.L., RA Sprague G.F. Jr., Frasch M., Nishimoto T.; RT "Mutation of the hamster cell cycle gene RCC1 is complemented by the RT homologous genes of Drosophila and S.cerevisiae."; RL EMBO J. 10:1265-1273(1991). RN [6] RP SUBCELLULAR LOCATION. RX PubMed=12121620; DOI=10.1016/S0960-9822(02)00934-X; RA Trieselmann N., Wilde A.; RT "Ran localizes around the microtubule spindle in vivo during mitosis RT in Drosophila embryos."; RL Curr. Biol. 12:1124-1129(2002). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286; THR-512; SER-526 RP AND THR-531, AND MASS SPECTROMETRY. RC TISSUE=Embryo; RX PubMed=18327897; DOI=10.1021/pr700696a; RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; RT "Phosphoproteome analysis of Drosophila melanogaster embryos."; RL J. Proteome Res. 7:1675-1682(2008). CC -!- FUNCTION: Promotes the exchange of Ran-bound GDP by GTP. Involved CC in the regulation of onset of chromosome condensation in the S CC phase. Binds to the chromatin. CC -!- INTERACTION: CC Q7Z2C5:-; NbExp=1; IntAct=EBI-181948, EBI-83985; CC Q9VIT1:-; NbExp=1; IntAct=EBI-181948, EBI-100923; CC Q9V4B8:CG10323; NbExp=1; IntAct=EBI-181948, EBI-145217; CC P28166:zfh1; NbExp=1; IntAct=EBI-181948, EBI-142903; CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Becomes dispersed CC throughout the cytoplasm during mitosis. Is associated with CC chromatin throughout mitosis. CC -!- SIMILARITY: Contains 7 RCC1 repeats. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X58530; CAA41417.1; -; Genomic_DNA. DR EMBL; AE014296; AAF50726.1; -; Genomic_DNA. DR EMBL; AE014296; AAF50727.1; -; Genomic_DNA. DR EMBL; AE014296; AAN12235.1; -; Genomic_DNA. DR EMBL; AY070540; AAL48011.1; -; mRNA. DR PIR; S15028; S15028. DR RefSeq; NP_523943.1; -. DR RefSeq; NP_729118.1; -. DR RefSeq; NP_729119.1; -. DR UniGene; Dm.8023; -. DR HSSP; P18754; 1I2M. DR DIP; DIP:17766N; -. DR IntAct; P25171; -. DR Ensembl; CG10480; Drosophila melanogaster. DR GeneID; 38669; -. DR KEGG; dme:Dmel_CG10480; -. DR FlyBase; FBgn0002638; Bj1. DR HOGENOM; P25171; -. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-015374-MON; -. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-015375-MON; -. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-015376-MON; -. DR NextBio; 809817; -. DR ArrayExpress; P25171; -. DR GermOnline; CG10480; Drosophila melanogaster. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0003682; F:chromatin binding; IDA:UniProtKB. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007417; P:central nervous system development; IDA:UniProtKB. DR GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB. DR GO; GO:0050767; P:regulation of neurogenesis; IMP:FlyBase. DR GO; GO:0046822; P:regulation of nucleocytoplasmic transport; IMP:FlyBase. DR InterPro; IPR000408; Reg_chr_condens. DR InterPro; IPR009091; Reg_csome_cond/b-lactamase_inh. DR Gene3D; G3DSA:2.130.10.30; Reg_csome_cond/b-lactamase_inh; 1. DR Pfam; PF00415; RCC1; 5. DR PRINTS; PR00633; RCCNDNSATION. DR PROSITE; PS00625; RCC1_1; 1. DR PROSITE; PS00626; RCC1_2; 2. DR PROSITE; PS50012; RCC1_3; 6. PE 1: Evidence at protein level; KW Cell cycle; Cell division; Complete proteome; Cytoplasm; KW Guanine-nucleotide releasing factor; Mitosis; Nucleus; Phosphoprotein; KW Repeat. FT CHAIN 1 547 Regulator of chromosome condensation. FT /FTId=PRO_0000206633. FT REPEAT 41 91 RCC1 1. FT REPEAT 92 143 RCC1 2. FT REPEAT 145 195 RCC1 3. FT REPEAT 197 257 RCC1 4. FT REPEAT 260 310 RCC1 5. FT REPEAT 311 362 RCC1 6. FT REPEAT 363 416 RCC1 7. FT REPEAT 417 454 Bj1 1. FT REPEAT 455 489 Bj1 2. FT REPEAT 490 519 Bj1 3. FT COMPBIAS 520 547 Glu/Lys-rich. FT MOD_RES 286 286 Phosphothreonine. FT MOD_RES 512 512 Phosphothreonine. FT MOD_RES 526 526 Phosphoserine. FT MOD_RES 531 531 Phosphothreonine. FT CONFLICT 490 490 V -> A (in Ref. 1; CAA41417). SQ SEQUENCE 547 AA; 58851 MW; 77D9744EBAF4597A CRC64; MPRRKALTNN NNAGEAEQQP PKAKRARIAF HLELPKRRTV LGNVLVCGNG DVGQLGLGED ILERKRLSPV AGIPDAVDIS AGGMHNLVLT KSGDIYSFGC NDEGALGRDT SEDGSESKPD LIDLPGKALC ISAGDSHSAC LLEDGRVFAW GSFRDSHGNM GLTIDGNKRT PIDLMEGTVC CSIASGADHL VILTTAGKVF TVGCAEQGQL GRLSERSISG EGRRGKRDLL RPTQLIITRA KPFEAIWATN YCTFMRESQT QVIWATGLNN FKQLAHETKG KEFALTPIKT ELKDIRHIAG GQHHTVILTT DLKCSVVGRP EYGRLGLGDV KDVVEKPTIV KKLTEKIVSV GCGEVCSYAV TIDGKLYSWG SGVNNQLGVG DGDDELEPIV VVSKNTQGKH MLLASGGGQH AIFLVKADKQ DQKENVPVKV SGSSSISKKD KTPPQDNVDK EAENVDKQEQ KENLPAKAST SSKKNKTPPQ DNADKEAENV DKQEQKENLP AKASTSSKKI KTPPQDDAAE EVEEESAQEP TPKKAKKPAA KRGGKKT //