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UniProtKB/Swiss-Prot entry P25024


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CXCR1_HUMAN
Primary accession number P25024
Secondary accession numbers Q2YEF8 Q2YEG4 Q2YEG5 Q2YEG7 Q2YEG8 Q53R18 Q6IN95 Q8N6T6 Q9P2T8 Q9P2T9 Q9P2U0 Q9P2U1 Q9P2U2
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on May 30, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 98)
Name and origin of the protein
Protein name High affinity interleukin-8 receptor A
Synonyms IL-8R A
IL-8 receptor type 1
CXCR-1
CDw128a
CD181 antigen
Gene name
Name: IL8RA
Synonyms: CMKAR1, CXCR1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT THR-276.
DOI=10.1126/science.1840701; PubMed=1840701 [NCBI, ExPASy, EBI, Israel, Japan]
Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.;
"Structure and functional expression of a human interleukin-8 receptor.";
Science 253:1278-1280(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
DOI=10.1016/0161-5890(93)90065-J; PubMed=8384312 [NCBI, ExPASy, EBI, Israel, Japan]
Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P.;
"Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.";
Mol. Immunol. 30:359-367(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1993.1167; PubMed=8486366 [NCBI, ExPASy, EBI, Israel, Japan]
Mollereau C., Passage E., Mattei M.-G., Vassart G., Parmentier M.;
"The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor.";
Genomics 16:248-251(1993).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=7929358 [NCBI, ExPASy, EBI, Israel, Japan]
Ahuja S.K., Shetty A., Tiffany H.L., Murphy P.M.;
"Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.";
J. Biol. Chem. 269:26381-26389(1994).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-31; THR-276 AND CYS-335.
DOI=10.1007/s00239-005-0039-x; PubMed=16205979 [NCBI, ExPASy, EBI, Israel, Japan]
Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.;
"Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.";
J. Mol. Evol. 61:691-696(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342.
SeattleSNPs variation discovery resource;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-31 AND CYS-335.
TISSUE=Blood;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350, AND VARIANTS THR-276; THR-306 AND CYS-335.
DOI=10.1038/sj.gene.6363682; PubMed=11196695 [NCBI, ExPASy, EBI, Israel, Japan]
Kato H., Tsuchiya N., Tokunaga K.;
"Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.";
Genes Immun. 1:330-337(2000).
[11]
CHARACTERIZATION.
PubMed=1379593 [NCBI, ExPASy, EBI, Israel, Japan]
Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I.;
"Characterization of two high affinity human interleukin-8 receptors.";
J. Biol. Chem. 267:16283-16287(1992).
[12]
STRUCTURE BY NMR OF 9-29 IN COMPLEX WITH IL-8.
DOI=10.1016/S0969-2126(99)80022-7; PubMed=10368283 [NCBI, ExPASy, EBI, Israel, Japan]
Skelton N.J., Quan C., Reilly D., Lowman H.;
"Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.";
Structure 7:157-168(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L19591; AAB59436.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L19592; AAA59160.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M68932; AAA59159.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X65858; CAA46688.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U11870; AAA64378.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916762; AAY21512.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916763; AAY21513.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916764; AAY21514.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916765; AAY21515.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916766; AAY21516.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916769; AAY21519.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916772; AAY21522.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY916773; AAY21523.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541994; CAG46791.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR542029; CAG46826.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY651785; AAT46689.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC097483; AAX93212.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028221; AAH28221.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC072397; AAH72397.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB032728; BAA92290.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB032729; BAA92291.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB032730; BAA92292.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB032731; BAA92293.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB032732; BAA92294.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00296618; -.
PIR I37449; A39445.
RefSeq NP_000625.1; -.
UniGene Hs.194778
3D structure databases
PDB
1ILP; NMR; -; C=9-29.[ExPASy / RCSB / EBI]
1ILQ; NMR; -; C=9-29.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1ILP; -.
1ILQ; -.
ModBase P25024.
Protein-protein interaction databases
DIP DIP:3779N; -.
Protein family/group databases
GPCRDB P25024; CXCR1_HUMAN.
Enzyme and pathway databases
Reactome REACT_14797; Signaling by GPCR.
Organism-specific databases
GeneCards GC02M218735; -.
H-InvDB HIX0002821; -.
HGNC HGNC:6026; IL8RA.
GenAtlas IL8RA.
HPA CAB016267; -.
MIM 146929; gene. [NCBI / EBI]
PharmGKB PA29842; -.
Gene expression databases
ArrayExpress P25024; -.
Bgee P25024; -.
GermOnline ENSG00000163464; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004918; Molecular function: interleukin-8 receptor activity (traceable author statement from ProtInc).
GO:0006935; Biological process: chemotaxis (traceable author statement from ProtInc).
GO:0007186; Biological process: G-protein coupled receptor protein signaling pathway (traceable author statement from ProtInc).
GO:0006954; Biological process: inflammatory response (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR000174; IL8_rcpt.
IPR001355; IL8A_rcpt.
Graphical view of domain structure.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00237; GPCRRHODOPSN.
PR00427; INTRLEUKIN8R.
PR00572; INTRLEUKN8AR.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P25024; -.
Genome annotation databases
Ensembl ENSG00000163464; Homo sapiens. [Contig view]
GeneID 3577; -.
KEGG hsa:3577; -.
Phylogenomic databases
HOVERGEN P25024; -.
OMA P25024; RILPHTF.
Other
NextBio 13982; -.
SOURCE IL8RA; Homo sapiens.
GPCRDB-Snakes P25024.
ProtoNet P25024.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   350  350     High affinity interleukin-8 receptor A. PRO_0000069330
TOPO_DOM   1    39  39     Extracellular (Potential). 
TRANSMEM   40    66  27     1 (Potential). 
TOPO_DOM   67    75  9     Cytoplasmic (Potential). 
TRANSMEM   76    96  21     2 (Potential). 
TOPO_DOM   97   111  15     Extracellular (Potential). 
TRANSMEM   112   133  22     3 (Potential). 
TOPO_DOM   134   154  21     Cytoplasmic (Potential). 
TRANSMEM   155   174  20     4 (Potential). 
TOPO_DOM   175   199  25     Extracellular (Potential). 
TRANSMEM   200   220  21     5 (Potential). 
TOPO_DOM   221   242  22     Cytoplasmic (Potential). 
TRANSMEM   243   264  22     6 (Potential). 
TOPO_DOM   265   285  21     Extracellular (Potential). 
TRANSMEM   286   308  23     7 (Potential). 
TOPO_DOM   309   350  42     Cytoplasmic (Potential). 
CARBOHYD   3     3        N-linked (GlcNAc...) (Potential). 
CARBOHYD   16    16        N-linked (GlcNAc...) (Potential). 
DISULFID   110   187        By similarity. 
VARIANT   31    31  1     M -> R (in dbSNP:rs16858811 [NCBI]). VAR_021061 
VARIANT   71    71  1     R -> C (in dbSNP:rs1805038 [NCBI]). VAR_016236 
VARIANT   268   268  1     M -> L (in dbSNP:rs9282752 [NCBI]). VAR_026525 
VARIANT   276   276  1     S -> T (common polymorphism; dbSNP:rs2234671 [NCBI]). VAR_003479 
VARIANT   306   306  1     A -> T. VAR_016237 
VARIANT   335   335  1     R -> C (in dbSNP:rs16858808 [NCBI]). VAR_016238 
VARIANT   342   342  1     S -> L (in dbSNP:rs16858806 [NCBI]). VAR_021062 
CONFLICT   154   154        K -> N (in Ref. 9; AAH72397). 
Sequence information
Length: 350 AA [This is the length of the unprocessed precursor] Molecular weight: 39791 Da [This is the MW of the unprocessed precursor] CRC64: 2463E868C0EB0DE2 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV 

        70         80         90        100        110        120 
MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN 

       130        140        150        160        170        180 
FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP 

       190        200        210        220        230        240 
NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA 

       250        260        270        280        290        300 
MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 

       310        320        330        340        350 
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL 

P25024 in FASTA format

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