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UniProtKB/Swiss-Prot entry P24822

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PPBI_MOUSE
Primary accession number P24822
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name Intestinal alkaline phosphatase [Precursor]
Synonyms IAP
EC 3.1.3.1
Gene name
Name: Iap
Synonyms: Akp-3, Akp3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0888-7543(90)90042-S; PubMed=2286375 [NCBI, ExPASy, EBI, Israel, Japan]
Manes T., Glade K., Ziomek C.A., Millan J.L.;
"Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.";
Genomics 8:541-554(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M61705; AAA37873.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B36307; B36307.
UniGene Mm.377076
3D structure databases
HSSP P05187; 1EW2. [HSSP ENTRY / PDB]
SMR P24822; 20-497.
ModBase P24822.
PTM databases
PhosphoSite P24822; -.
Organism-specific databases
MGI MGI:87984; Akp3.
Gene expression databases
ArrayExpress P24822; -.
GermOnline ENSMUSG00000036500; Mus musculus.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004035; Molecular function: alkaline phosphatase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
GO:0035264; Biological process: multicellular organism growth (inferred from mutant phenotype from MGI).
GO:0021915; Biological process: neural tube development (inferred from mutant phenotype from MGI).
GO:0022008; Biological process: neurogenesis (inferred from mutant phenotype from MGI).
GO:0035121; Biological process: tail morphogenesis (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR017849; Alkaline_Pase-like_a/b/a.
IPR001952; Alkaline_phosphatase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.720.10; Alk_phosphtse; 1.
Pfam PF00245; Alk_phosphatase; 1.
Pfam graphical view of domain structure.
PRINTS PR00113; ALKPHPHTASE.
SMART SM00098; alkPPc; 1.
SMART graphical view of domain structure.
PROSITE PS00123; ALKALINE_PHOSPHATASE; 1.
ProtoNet P24822.
Genome annotation databases
Ensembl ENSMUSG00000036500; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM P24822; -.
HOVERGEN P24822; -.
Other
SOURCE Iap; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Magnesium; Membrane; Metal-binding; Phosphoprotein; Signal; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   528  509     Intestinal alkaline phosphatase. PRO_0000024039
PROPEP   529   559  31     Removed in mature form (Potential). PRO_0000024040
COMPBIAS   503   507  5     Poly-Thr. 
COMPBIAS   510   524  15     Poly-Thr. 
ACT_SITE   111   111        Phosphoserine intermediate. 
METAL   61    61        Magnesium (Potential). 
METAL   61    61        Zinc 2 (Potential). 
METAL   330   330        Magnesium (Potential). 
METAL   335   335        Zinc 1 (Potential). 
METAL   339   339        Zinc 1 (Potential). 
METAL   376   376        Zinc 2 (Potential). 
METAL   377   377        Zinc 2 (Potential). 
METAL   450   450        Zinc 1 (Potential). 
MOD_RES   111   111        Phosphoserine (By similarity). 
LIPID   528   528        GPI-anchor amidated asparagine (Potential). 
CARBOHYD   141   141        N-linked (GlcNAc...) (Potential). 
CARBOHYD   241   241        N-linked (GlcNAc...) (Potential). 
CARBOHYD   426   426        N-linked (GlcNAc...) (Potential). 
DISULFID   140   202        By similarity. 
DISULFID   485   492        By similarity. 
Sequence information
Length: 559 AA [This is the length of the unprocessed precursor] Molecular weight: 60285 Da [This is the MW of the unprocessed precursor] CRC64: 019EBB4363950878 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQGPWVLLLL GLRLQLSLSV IPVEEENPAF WNKKAAEALD AAKKLQPIQT SAKNLIIFLG 

        70         80         90        100        110        120 
DGMGVPTVTA TRILKGQLEG HLGPETPLAM DRFPYMALSK TYSVDRQVPD SASTATAYLC 

       130        140        150        160        170        180 
GVKTNYKTIG LSAAARFDQC NTTFGNEVFS VMYRAKKAGK SVGVVTTTRV QHASPSGTYV 

       190        200        210        220        230        240 
HTVNRNWYGD ADMPASALRE GCKDIATQLI SNMDINVILG GGRKYMFPAG TPDPEYPNDA 

       250        260        270        280        290        300 
NETGTRLDGR NLVQEWLSKH QGSQYVWNRE QLIQKAQDPS VTYLMGLFEP VDTKFDIQRD 

       310        320        330        340        350        360 
PLMDPSLKDM TETAVKVLSR NPKGFYLFVE GGRIDRGHHL GTAYLALTEA VMFDLAIERA 

       370        380        390        400        410        420 
SQLTSERDTL TIVTADHSHV FSFGGYTLRG TSIFGLAPLN ALDGKPYTSI LYGNGPGYVG 

       430        440        450        460        470        480 
TGERPNVTAA ESSGSSYRRQ AAVPVKSETH GGEDVAIFAR GPQAHLVHGV QEQNYIAHVM 

       490        500        510        520        530        540 
ASAGCLEPYT DCGLAPPADE SQTTTTTRQT TITTTTTTTT TTTTPVHNSA RSLGPATAPL 

       550 
ALALLAGMLM LLLGAPAES
P24822 in FASTA format

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