ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P24802

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name PLOD1_CHICK
Primary accession number P24802
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [Precursor]
Synonyms EC 1.14.11.4
Lysyl hydroxylase 1
LH1
Gene name
Name: PLOD1
Synonyms: PLOD
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 21-40; 412-417; 508-515 AND 550-573.
PubMed=1704364 [NCBI, ExPASy, EBI, Israel, Japan]
Kivirikko K.I., Turpeenniemi-Hujanen T., Pajunen L., Pihlajaniemi T., Myllylae R.;
"Molecular cloning of chick lysyl hydroxylase. Little homology in primary structure to the two types of subunit of prolyl 4-hydroxylase.";
J. Biol. Chem. 266:2805-2810(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M59183; AAA48945.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A23742; A23742.
RefSeq NP_001005618.1; -.
UniGene Gga.4726
3D structure databases
ModBase P24802.
Ontologies
GO
GO:0030867; Cellular component: rough endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0031418; Molecular function: L-ascorbic acid binding (inferred from electronic annotation from UniProtKB-KW).
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (inferred from electronic annotation from UniProtKB-KW).
GO:0008475; Molecular function: procollagen-lysine 5-dioxygenase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019538; Biological process: protein metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR005123; 2OG-FeII_Oase.
IPR006620; Pro_4_hyd_alph.
IPR001006; Procol_lys_dOase.
Graphical view of domain structure.
Pfam PF03171; 2OG-FeII_Oxy; 1.
Pfam graphical view of domain structure.
ProDom PD011578; ProcolLys_dioxy; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00702; P4Hc; 1.
SMART graphical view of domain structure.
PROSITE PS01325; LYS_HYDROXYLASE; 1.
ProtoNet P24802.
Genome annotation databases
Ensembl ENSGALG00000004531; Gallus gallus. [Contig view]
GeneID 419485; -.
KEGG gga:419485; -.
Phylogenomic databases
HOGENOM P24802; -.
HOVERGEN P24802; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Iron; Membrane; Metal-binding; Oxidoreductase; Signal; Vitamin C.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20      
CHAIN   21   730  710     Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. PRO_0000024682
DOMAIN   556   730  175     PKHD. 
ACT_SITE   721   721        Potential. 
METAL   659   659        Iron (By similarity). 
METAL   661   661        Iron (By similarity). 
METAL   711   711        Iron (By similarity). 
CARBOHYD   200   200        N-linked (GlcNAc...) (Potential). 
CARBOHYD   403   403        N-linked (GlcNAc...) (Potential). 
CARBOHYD   541   541        N-linked (GlcNAc...) (Potential). 
CARBOHYD   689   689        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 730 AA [This is the length of the unprocessed precursor] Molecular weight: 84318 Da [This is the MW of the unprocessed precursor] CRC64: CE588F720D4F98E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVPPAVLLPW VVLPLLGVQG GSGSKQEENL LVLTVATKQT EGFRRFRRSA QFFNYKIQVL 

        70         80         90        100        110        120 
GLDEEWKGGD DKKPAGGGQK VRLLKSALKQ HADKEDLVIL FIESYDVLFA SGPTELLKKF 

       130        140        150        160        170        180 
KQAKSKVVFS AENYIYPDRK LEAKYPPVRD GKRFLGSGGF IGYAPNLKKL VEEWKGKDDD 

       190        200        210        220        230        240 
SDQLFYTKIF LDPEKRENIN ISLDHRSRIF QNLNGALDEV VLKFENARVR ARNLLYDTLP 

       250        260        270        280        290        300 
VIIHGNGPTK LQLNYLGNYI PQIWTFETGC TVCDEGLRSL TGIKDEALPM ILIGIFIEQP 

       310        320        330        340        350        360 
TPFLSQFFLR LRNLHYPKQR IQIFIHNHEE HHSMQVDSFV KEHSKEYLAM KVIGPDDEVE 

       370        380        390        400        410        420 
NAEARNLGMD LCRKDPDCDY YFSLDAEVVL KNTETLRILI EQNKSVIAPL VSRHEKLWSN 

       430        440        450        460        470        480 
FWGALSPDGY YARSEDYVDI VQRRRVGLWN VPYISSVYMV KGKVLRSELD EGDLFHGGKL 

       490        500        510        520        530        540 
DADMAFCHNV RNQGVFMYLT NRHQFGHILS LENYQTTHLH NDLWQIFSNP EDWREKYIHE 

       550        560        570        580        590        600 
NYTAALKGKL VEMPCPDVYW FPIFTDTACD ELVEEMEHYG KWSTGDNTDS RIQGGYENVP 

       610        620        630        640        650        660 
TIDIHMNQIG FEREWYKFLL DYIAPITEKL YPGYYTKTQF ELAFVVRYKP DEQPSLMPHH 

       670        680        690        700        710        720 
DASTFTINIA LNRVGIDYEG GGCRFLRYNC SIRAPRKGWT LMHPGRLTHY HEGLPTTKGT 

       730 
RYIAVSFIDP
P24802 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!