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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Neurula;
DOI=10.1016/0092-8674(91)90573-H; PubMed=1717160 [NCBI, ExPASy, EBI, Israel, Japan]
Smith J.C.,
Price B.M.,
Green J.B.,
Weigel D.,
Herrmann B.G.;
"Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.";
Cell 67:79-87(1991).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[3]
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FUNCTION.
PubMed=7906224 [NCBI, ExPASy, EBI, Israel, Japan]
Cunliffe V.,
Smith J.C.;
"Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.";
EMBO J. 13:349-359(1994).
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[4]
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INDUCTION.
PubMed=10068640 [NCBI, ExPASy, EBI, Israel, Japan]
Sun B.I.,
Bush S.M.,
Collins-Racie L.A.,
LaVallie E.R.,
DiBlasio-Smith E.A.,
Wolfman N.M.,
McCoy J.M.,
Sive H.L.;
"derriere: a TGF-beta family member required for posterior development in Xenopus.";
Development 126:1467-1482(1999).
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[5]
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INDUCTION.
PubMed=10375512 [NCBI, ExPASy, EBI, Israel, Japan]
Osada S.,
Wright C.V.E.;
"Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis.";
Development 126:3229-3240(1999).
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[6]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-222.
DOI=10.1038/39929; PubMed=9349824 [NCBI, ExPASy, EBI, Israel, Japan]
Mueller C.W.,
Herrmann B.G.;
"Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor.";
Nature 389:884-888(1997).
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- FUNCTION: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Causes dorsal mesodermal differentiation of animal cap ectoderm when co-expressed with XWNT-8 and Noggin. None of these molecules causes dorsal mesoderm formation when expressed alone.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Nucleus.
- TISSUE SPECIFICITY: Expressed in presumptive mesodermal cells around the blastopore, and then in the notochord.
- DEVELOPMENTAL STAGE: During gastrula and neurula stages in involuting mesoderm and in the notochord.
- INDUCTION: By the natural signal and in response to the mesoderm-inducing factors activin A, basic FGF/bFGF, derriere, nodal/nr-1, nodal2/nr-2 and nodal4/nr-4.
- SIMILARITY: Contains 1 T-box DNA-binding domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 432 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47599 Da [This is the MW of the unprocessed precursor] |
CRC64: 2F91D942D86EE60A [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSATESCAKN VQYRVDHLLS AVENELQAGS EKGDPTEKEL KVSLEERDLW TRFKELTNEM
70 80 90 100 110 120
IVTKNGRRMF PVLKVSMSGL DPNAMYTVLL DFVAADNHRW KYVNGEWVPG GKPEPQAPSC
130 140 150 160 170 180
VYIHPDSPNF GAHWMKDPVS FSKVKLTNKM NGGGQIMLNS LHKYEPRIHI VRVGGTQRMI
190 200 210 220 230 240
TSHSFPETQF IAVTAYQNEE ITALKIKHNP FAKAFLDAKE RNDYKDILDE GIDSQHSNFS
250 260 270 280 290 300
QLGTWLIPNG GSLCSPNPHT QFGAPLSLSS PHGCERYSSL RNHRSAPYPS PYTHRNNSPN
310 320 330 340 350 360
NLADNSSACL SMLQSHDNWS TLQMPAHTGM LPMSHSTGTP PPSSQYPSLW SVSNSAITPV
370 380 390 400 410 420
SQSGGITNGI SSQYLLGSTP HYSSLSHAVP SPSTGSPLYE HGAQTEIAEN QYDVTAHSRL
430
SSTWTPVAPP SV
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P24781 in FASTA format |
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