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UniProtKB/Swiss-Prot entry P24722

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KCRT_ONCMY
Primary accession number P24722
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 1992 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 40)
Name and origin of the protein
Protein name Creatine kinase, testis isozyme
Synonym EC 2.7.3.2
Gene name
Name: tck1
From
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
DOI=10.1016/0167-4781(90)90215-N; PubMed=2223887 [NCBI, ExPASy, EBI, Israel, Japan]
Garber A.T., Winkfein R.J., Dixon G.H.;
"A novel creatine kinase cDNA whose transcript shows enhanced testicular expression.";
Biochim. Biophys. Acta 1087:256-258(1990).
Comments
  • FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
  • CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
  • TISSUE SPECIFICITY: Exists in many tissues, but preferentially in testis.
  • SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53859; CAA37852.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13164; S13164.
RefSeq NP_001118187.1; -.
3D structure databases
HSSP P00563; 2CRK. [HSSP ENTRY / PDB]
SMR P24722; 15-383.
ModBase P24722.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004111; Molecular function: creatine kinase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR000749; ATP-gua_Ptrans.
IPR014746; Gln_synth/guanido_kin_cat.
Graphical view of domain structure.
Gene3D G3DSA:1.10.135.10; ATP-gua_Ptrans; 1.
G3DSA:3.30.590.10; ATP-gua_Ptrans; 1.
PANTHER PTHR11547; ATP-gua_Ptrans; 1.
Pfam PF00217; ATP-gua_Ptrans; 1.
PF02807; ATP-gua_PtransN; 1.
Pfam graphical view of domain structure.
PROSITE PS00112; GUANIDO_KINASE; 1.
ProtoNet P24722.
Genome annotation databases
GeneID 100136767; -.
Phylogenomic databases
HOVERGEN P24722; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Nucleotide-binding; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   383  383     Creatine kinase, testis isozyme. PRO_0000211984
NP_BIND   130   134  5     ATP (By similarity). 
NP_BIND   322   327  6     ATP (By similarity). 
BINDING   193   193        ATP (By similarity). 
BINDING   238   238        ATP (By similarity). 
BINDING   294   294        ATP (By similarity). 
BINDING   337   337        ATP (By similarity). 
Sequence information
Length: 383 AA [This is the length of the unprocessed precursor] Molecular weight: 43004 Da [This is the MW of the unprocessed precursor] CRC64: 608BAAA115C7D1EA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEKINDKMAK LTIKRLSPEE EFPDLSQHNN HMAKVLTQDM YTKLRDRATP NGFTIDGVIQ 

        70         80         90        100        110        120 
TGIDNPGHPF IMTVGCVAGD EETYEVFKEL LDPIIEDRHG GYKPTDKHKT DLNPDNLKGG 

       130        140        150        160        170        180 
DDLDPNYVIS SRVRTGRSIR GFCLPPHCSR GERRGVEKMS VEALDSLSGD LKGKYYALKN 

       190        200        210        220        230        240 
MTDAEQQQLI DDHFLFDKPV SPLLLASGMA RDWPDGRGIW HNDTKTFLVW VNEEDHLRVI 

       250        260        270        280        290        300 
SMQKGGNMKE VFNRFCTGLT KIETLFKDKG TSFMWNEHLG YVLTCPSNLG TGLRAGVHVK 

       310        320        330        340        350        360 
IPNISKHAKF EEVLKRLRLQ KRGTGGVDTA AVGGTFDISN ADRLGFSEVE LVQMVVDGVK 

       370        380 
LLVEMEKKLE KGQSIDDLMP AQK
P24722 in FASTA format

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