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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS.
TISSUE=Thyroid;
PubMed=1512224 [NCBI, ExPASy, EBI, Israel, Japan]
Carr D.W.,
Stofko-Hahn R.E.,
Fraser I.D.C.,
Cone R.D.,
Scott J.D.;
"Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.";
J. Biol. Chem. 267:16816-16823(1992).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 332-427.
TISSUE=Kidney;
PubMed=1733921 [NCBI, ExPASy, EBI, Israel, Japan]
Hirsch A.H.,
Glantz S.B.,
Li Y.,
You Y.,
Rubin C.S.;
"Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta.";
J. Biol. Chem. 267:2131-2134(1992).
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- FUNCTION: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
- SUBUNIT: Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor.
- INTERACTION:
P63252:KCNJ2; NbExp=1; IntAct=EBI-703640, EBI-703457;
P35561:Kcnj2 (xeno); NbExp=2; IntAct=EBI-703640, EBI-703793;
- SUBCELLULAR LOCATION: Membrane. Note=Associated with particulate fractions.
- TISSUE SPECIFICITY: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.
- DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
- MISCELLANEOUS: The N-terminal region, which is highly basic, is required for interaction with calmodulin.
- SIMILARITY: Contains 1 AKAP domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 427 AA [This is the length of the unprocessed precursor] |
Molecular weight: 47072 Da [This is the MW of the unprocessed precursor] |
CRC64: A3D08AE8D0521408 [This is a checksum on the sequence] |
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10 20 30 40 50 60
METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK AGSEAADVAR
70 80 90 100 110 120
KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP LEGEMQPAIN AEDADLSKKK
130 140 150 160 170 180
AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ
190 200 210 220 230 240
DLSEGISQKD GDEVCESNVS NSITSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ
250 260 270 280 290 300
DVQPQQASPL ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPN GKDYESTEIV
310 320 330 340 350 360
AEETKPKDTE LSQESDFKEN GITEEKSKSE ESKRMEPIAI IITDTEISEF DVTKSKNVPK
370 380 390 400 410 420
QFLISAENEQ VGVFANDNGF EDRTSEQYET LLIETASSLV KNAIQLSIEQ LVNEMASDDN
KINNLLQ
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P24588 in FASTA format |
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