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UniProtKB/Swiss-Prot entry P24529

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TY3H_MOUSE
Primary accession number P24529
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 71)
Name and origin of the protein
Protein name Tyrosine 3-monooxygenase
Synonyms EC 1.14.16.2
Tyrosine 3-hydroxylase
TH
Gene name
Name: Th
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0006-291X(91)90472-J; PubMed=1674869 [NCBI, ExPASy, EBI, Israel, Japan]
Ichikawa S., Sasaoka T., Nagatsu T.;
"Primary structure of mouse tyrosine hydroxylase deduced from its cDNA.";
Biochem. Biophys. Res. Commun. 176:1610-1616(1991).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-30.
STRAIN=BALB/c;
Morgan W.W., Bermudez J., Sharp Z.D.;
Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
[3]
 PROTEIN SEQUENCE OF 78-90.
TISSUE=Brain;
Lubec G., Yang J.W., Zigmond M.;
Submitted (JUL-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M69200; AAA40434.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X53503; CAA37580.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JN0068; JN0068.
RefSeq NP_033403.1; -.
UniGene Mm.1292
3D structure databases
HSSP P04177; 1TOH. [HSSP ENTRY / PDB]
SMR P24529; 159-497, 160-498.
ModBase P24529.
PTM databases
PhosphoSite P24529; -.
Organism-specific databases
MGI MGI:98735; Th.
Gene expression databases
ArrayExpress P24529; -.
CleanEx MM_TH; -.
GermOnline ENSMUSG00000000214; Mus musculus.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from direct assay from MGI).
GO:0043204; Cellular component: perikaryon (inferred from direct assay from MGI).
GO:0004511; Molecular function: tyrosine 3-monooxygenase activity (traceable author statement from MGI).
GO:0006585; Biological process: dopamine biosynthetic process from tyrosine (inferred from direct assay from MGI).
GO:0042755; Biological process: eating behavior (inferred from mutant phenotype from MGI).
GO:0048596; Biological process: embryonic camera-type eye morphogenesis (inferred from mutant phenotype from UniProtKB).
GO:0042462; Biological process: eye photoreceptor cell development (inferred from mutant phenotype from UniProtKB).
GO:0007507; Biological process: heart development (inferred from mutant phenotype from MGI).
GO:0007612; Biological process: learning (inferred from mutant phenotype from MGI).
GO:0007626; Biological process: locomotory behavior (inferred from mutant phenotype from MGI).
GO:0007617; Biological process: mating behavior (inferred from mutant phenotype from MGI).
GO:0007613; Biological process: memory (inferred from mutant phenotype from MGI).
GO:0042136; Biological process: neurotransmitter biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0008016; Biological process: regulation of heart contraction (inferred from mutant phenotype from MGI).
GO:0001963; Biological process: synaptic transmission, dopaminergic (inferred from mutant phenotype from MGI).
GO:0007601; Biological process: visual perception (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR005962; Tyr_3_mOase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01269; Tyr_3_monoox; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
ProtoNet P24529.
Genome annotation databases
Ensembl ENSMUSG00000000214; Mus musculus. [Contig view]
GeneID 21823; -.
KEGG mmu:21823; -.
Phylogenomic databases
HOGENOM P24529; -.
HOVERGEN P24529; -.
Other
NextBio 301244; -.
SOURCE Th; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Catecholamine biosynthesis; Direct protein sequencing; Iron; Metal-binding; Monooxygenase; Neurotransmitter biosynthesis; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   498  497     Tyrosine 3-monooxygenase. PRO_0000205562
COMPBIAS   51    59  9     Poly-Ala. 
METAL   331   331        Iron (By similarity). 
METAL   336   336        Iron (By similarity). 
METAL   376   376        Iron (By similarity). 
MOD_RES   19    19        Phosphoserine; by CaMK2 (By similarity). 
MOD_RES   31    31        Phosphoserine (By similarity). 
MOD_RES   40    40        Phosphoserine; by PKA (By similarity). 
Sequence information
Length: 498 AA [This is the length of the unprocessed precursor] Molecular weight: 55993 Da [This is the MW of the unprocessed precursor] CRC64: 62790179664F6DC6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE AAAAAAAAAV 

        70         80         90        100        110        120 
ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA LKVFETFEAK IHHLETRPAQ 

       130        140        150        160        170        180 
RPLAGSPHLE YFVRFEVPSG DLAALLSSVR RVSDDVRSAR EDKVPWFPRK VSELDKCHHL 

       190        200        210        220        230        240 
VTKFDPDLDL DHPGFSDQAY RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL 

       250        260        270        280        290        300 
KGLYATHACR EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF 

       310        320        330        340        350        360 
LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ DIGLASLGAS 

       370        380        390        400        410        420 
DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL LHSLSEEPEV RAFDPDTAAV 

       430        440        450        460        470        480 
QPYQDQTYQP VYFVSESFSD AKDKLRNYAS RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL 

       490 
EGVQDELHTL TQALSAIS
P24529 in FASTA format

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