ID   NTP1_CBEPV              Reviewed;         648 AA.
AC   P24486;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-NOV-2008, entry version 50.
DE   RecName: Full=Nucleoside triphosphatase I;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase I;
DE            Short=NPH I;
GN   Name=NPH1;
OS   Choristoneura biennis entomopoxvirus (CbEPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Entomopoxvirinae;
OC   Betaentomopoxvirus.
OX   NCBI_TaxID=10288;
OH   NCBI_TaxID=7141; Choristoneura fumiferana (Spruce budworm).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91220681; PubMed=1850911; DOI=10.1016/0042-6822(91)90690-D;
RA   Yuen L., Noiseux M., Gomes M.;
RT   "DNA sequence of the nucleoside triphosphate phosphohydrolase I (NPH
RT   I) of the Choristoneura biennis entomopoxvirus.";
RL   Virology 182:403-406(1991).
CC   -!- FUNCTION: Serves two roles in transcription; it acts in concert
CC       with viral termination factor/capping enzyme to catalyze release
CC       of UUUUUNU-containing nascent RNA from the elongation complex, and
CC       it acts by itself as a polymerase elongation factor to facilitate
CC       readthrough of intrinsic pause sites (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SIMILARITY: Belongs to the helicase family. NPH I subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR   EMBL; M60400; AAA42886.1; -; Genomic_DNA.
DR   PIR; A39154; NPVZCP.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_N.
DR   InterPro; IPR001650; DNA/RNA_helicase_C.
DR   InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd.
DR   InterPro; IPR013676; NPHI_C.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08469; NPHI_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Transcription.
FT   CHAIN         1    648       Nucleoside triphosphatase I.
FT                                /FTId=PRO_0000099100.
FT   DOMAIN       48    213       Helicase ATP-binding.
FT   DOMAIN      379    542       Helicase C-terminal.
FT   NP_BIND      61     68       ATP (By similarity).
FT   MOTIF       151    154       DEXH box.
SQ   SEQUENCE   648 AA;  76116 MW;  C61BA6EA5D36F892 CRC64;
     MFALDSIVGK HINYALDKTQ HLPNKINNSI TNTEITLQDY QYFASRIFIG LKNLNSMLLF
     WDTGTGKTLT AVYIIKYIKE LFPRWIILIF IKKSLYIDPW LNTISSYISD TSNIKFIYYD
     STSSLDKKFN NIYRSIESSL NKKNRLLIII DEVHKLISRS VKKDNNERNF TPIYRKLIKL
     ANYENNKILC MSATPITNNI AEFNNLIGLL RPNVMNIKEE YINNGKLINF KEVRETLLGI
     CSYKRLIEAD SLTDTNYIDG YAKKSIFYHN IIMSDEQSKL YNMAERYDYK TELGGLKTMR
     RLISSFAFYD LKIKGDLDNV EYNEMIKRKL AEFSEFTKNI NFSKAFINAF KNNEIKSKTD
     LLITDINNYN ILYQYSCKYI EACRIILNSR GKVLLFEPLV NFEGISSLKY YFNCFNISYI
     EYSSKTIKMR DNDLNEYNNY ENNDGNKIKV CIFSYAGSEG ISFKCINDII ILDMPWNESE
     LKQIIGRSIR LNSHEYLPIN YRYVNVHFII SYSNNRKSVD KEMLDIIKNK QGKINVVFDL
     LKASSIETIH NMHKYIEPVD NEIIFEIIRK TRMKEMNISN VIINLKLYPI TYCKDYDRAT
     ILKGFLNKDT NIIYDNDTPV AKLIVDNNNL PIFVIENDIL IYITNDYY
//