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UniProtKB/Swiss-Prot entry P24385


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCND1_HUMAN
Primary accession number P24385
Secondary accession number Q6LEF0
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 1992 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 98)
Name and origin of the protein
Protein name G1/S-specific cyclin-D1
Synonyms PRAD1 oncogene
BCL-1 oncogene
Gene name
Name: CCND1
Synonyms: BCL1, PRAD1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE.
DOI=10.1038/350512a0; PubMed=1826542 [NCBI, ExPASy, EBI, Israel, Japan]
Motokura T., Bloom T., Kim H.G., Jueppner H., Ruderman J.V., Kronenberg H.M., Arnold A.;
"A novel cyclin encoded by a bcl1-linked candidate oncogene.";
Nature 350:512-515(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0092-8674(91)90042-W; PubMed=1833066 [NCBI, ExPASy, EBI, Israel, Japan]
Lew D.J., Dulic V., Reed S.I.;
"Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.";
Cell 66:1197-1206(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0092-8674(91)90100-D; PubMed=1827756 [NCBI, ExPASy, EBI, Israel, Japan]
Xiong Y., Connolly T., Futcher B., Beach D.;
"Human D-type cyclin.";
Cell 65:691-699(1991).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1833629 [NCBI, ExPASy, EBI, Israel, Japan]
Withers D.A., Harvey R.C., Faust J.B., Melnyk O., Carey K., Meeker T.C.;
"Characterization of a candidate bcl-1 gene.";
Mol. Cell. Biol. 11:4846-4853(1991).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8204893 [NCBI, ExPASy, EBI, Israel, Japan]
Rimokh R., Berger F., Bastard C., Klein B., French M., Archimbaud E., Rouault J.-P., Santa Lucia B., Duret L., Vuillaume M.;
"Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias.";
Blood 83:3689-3696(1994).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66.
TISSUE=Placenta;
PubMed=7687458 [NCBI, ExPASy, EBI, Israel, Japan]
Motokura T., Arnold A.;
"The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint.";
Genes Chromosomes Cancer 7:89-95(1993).
[10]
INTERACTION WITH CDK4 AND CDK6.
PubMed=8302605 [NCBI, ExPASy, EBI, Israel, Japan]
Bates S., Bonetta L., McAllan D., Parry D., Holder A., Dickson C., Peters G.;
"CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.";
Oncogene 9:71-79(1994).
[11]
INVOLVEMENT IN MULTIPLE MYELOMA.
PubMed=8695815 [NCBI, ExPASy, EBI, Israel, Japan]
Chesi M., Bergsagel P.L., Brents L.A., Smith C.M., Gerhard D.S., Kuehl W.M.;
"Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.";
Blood 88:674-681(1996).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-226, AND MASS SPECTROMETRY.
DOI=10.1038/sj.emboj.7601384; PubMed=17053785 [NCBI, ExPASy, EBI, Israel, Japan]
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A., Lottspeich F., Chen Z.;
"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.";
EMBO J. 25:5058-5070(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X59798; CAA42470.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M74092; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
M64349; AAA52136.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M73554; AAA58392.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z23022; CAA80558.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019845; AAV38648.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF511593; AAM34300.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000076; AAH00076.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC001501; AAH01501.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014078; AAH14078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC023620; AAH23620.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC025302; AAH25302.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L09054; AAA36481.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A38977; A38977.
RefSeq NP_444284.1; -.
UniGene Hs.523852
3D structure databases
ModBase P24385.
Protein-protein interaction databases
DIP DIP:123N; -.
IntAct P24385; -.
PTM databases
PhosphoSite P24385; -.
Enzyme and pathway databases
Reactome REACT_152; Cell Cycle, Mitotic.
Polymorphism databases
NIEHS-SNPs CCND1.
Organism-specific databases
H-InvDB HIX0009889; -.
HGNC HGNC:1582; CCND1.
GenAtlas CCND1.
HPA CAB000024; -.
MIM 168461; gene. [NCBI / EBI]
254500; phenotype. [NCBI / EBI]
Orphanet 69; Amyloidosis.
29073; Myeloma, multiple.
PharmGKB PA75; -.
GeneCards P24385.
Gene expression databases
ArrayExpress P24385; -.
CleanEx HS_CCND1; -.
GermOnline ENSG00000110092; Homo sapiens.
Ontologies
GO
GO:0000307; Cellular component: cyclin-dependent protein kinase holoenzyme complex (inferred from direct assay from UniProtKB).
GO:0005829; Cellular component: cytosol (inferred from experiment from Reactome).
GO:0005654; Cellular component: nucleoplasm (inferred from experiment from Reactome).
GO:0019901; Molecular function: protein kinase binding (inferred from physical interaction from UniProtKB).
GO:0000082; Biological process: G1/S transition of mitotic cell cycle (non-traceable author statement from UniProtKB).
GO:0045737; Biological process: positive regulation of cyclin-dependent protein kinase activity (inferred from direct assay from UniProtKB).
GO:0001934; Biological process: positive regulation of protein amino acid phosphorylation (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR015451; CycD.
IPR006670; Cyclin.
IPR014400; Cyclin_A_B_D_E.
IPR004367; Cyclin_C.
IPR006671; Cyclin_N.
IPR013763; Cyclin_related.
Graphical view of domain structure.
Gene3D G3DSA:1.10.472.10; Cyclin_related; 1.
PANTHER PTHR10177:SF12; CycD; 1.
Pfam PF02984; Cyclin_C; 1.
PF00134; Cyclin_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001771; Cyclin_A_B_D_E; 1.
SMART SM00385; CYCLIN; 1.
SMART graphical view of domain structure.
PROSITE PS00292; CYCLINS; 1.
BLOCKS P24385.
Genome annotation databases
Ensembl ENSG00000110092; Homo sapiens. [Contig view]
GeneID 595; -.
KEGG hsa:595; -.
Phylogenomic databases
HOGENOM P24385; -.
HOVERGEN P24385; -.
Other
DrugBank DB01169; Arsenic trioxide.
LinkHub P24385; -.
SOURCE CCND1; Homo sapiens.
ProtoNet P24385.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell cycle; Cell division; Chromosomal rearrangement; Cyclin; Phosphoprotein; Proto-oncogene.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   295  295     G1/S-specific cyclin-D1. PRO_0000080430
MOD_RES   226   226        Phosphotyrosine. 
CONFLICT   130   130        N -> G (in Ref. 3; AAA52136). 
CONFLICT   168   169        MP -> IA (in Ref. 2; M74092). 
CONFLICT   188   188        L -> S (in Ref. 3; AAA52136). 
Sequence information
Length: 295 AA [This is the length of the unprocessed precursor] Molecular weight: 33729 Da [This is the MW of the unprocessed precursor] CRC64: 3CC00C9905F58D3A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EVLPSMRKIV 

        70         80         90        100        110        120 
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT 

       130        140        150        160        170        180 
AEKLCIYTDN SIRPEELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPE AEENKQIIRK 

       190        200        210        220        230        240 
HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD 

       250        260        270        280        290 
PDCLRACQEQ IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI 

P24385 in FASTA format

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View entry in raw text format (no links)
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