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UniProtKB/Swiss-Prot entry P24293

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PA21B_ERIMA
Primary accession number P24293
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 1992 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Phospholipase A2 isozyme PLA-1
Synonyms EC 3.1.1.4
Phosphatidylcholine 2-acylhydrolase
Gene name None
From
Eristocophis macmahoni (Leaf-nosed viper) [TaxID: 8702] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Viperidae; Viperinae; Eristocophis.
Protein existence 1: Evidence at protein level;
References
[1]
 PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=1935962 [NCBI, ExPASy, EBI, Israel, Japan]
Siddiqi A.R., Zaidi Z.H., Joernvall H.;
"Purification and characterization of two highly different group II phospholipase A2 isozymes from a single viperid (Eristocophis macmahoni) venom.";
Eur. J. Biochem. 201:675-679(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
PIR S17860; S17860.
3D structure databases
HSSP P81458; 1VIP. [HSSP ENTRY / PDB]
ModBase P24293.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0004623; Molecular function: phospholipase A2 activity (inferred from electronic annotation from InterPro).
GO:0016042; Biological process: lipid catabolic process (inferred from electronic annotation from InterPro).
GO:0006644; Biological process: phospholipid metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR016090; Phospholipase_A2.
IPR013090; Phospholipase_A2_AS.
IPR001211; Phospholipase_A2_euk.
Graphical view of domain structure.
Gene3D G3DSA:1.20.90.10; Phospholipase_A2; 1.
PANTHER PTHR11716; Phospholipase_A2; 1.
Pfam PF00068; Phospholip_A2_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00389; PHPHLIPASEA2.
ProDom PD000303; PhospholipaseA2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00085; PA2c; 1.
SMART graphical view of domain structure.
PROSITE PS00119; PA2_ASP; 1.
PS00118; PA2_HIS; 1.
ProtoNet P24293.
Phylogenomic databases
HOVERGEN P24293; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Metal-binding; Secreted.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   121  121     Phospholipase A2 isozyme PLA-1. PRO_0000161645
ACT_SITE   47    47        By similarity. 
ACT_SITE   89    89        By similarity. 
METAL   27    27        Calcium; via carbonyl oxygen (By similarity). 
METAL   29    29        Calcium; via carbonyl oxygen (By similarity). 
METAL   31    31        Calcium; via carbonyl oxygen (By similarity). 
METAL   48    48        Calcium (By similarity). 
DISULFID   26   115        By similarity. 
DISULFID   28    44        By similarity. 
DISULFID   43    95        By similarity. 
DISULFID   49   121        By similarity. 
DISULFID   50    88        By similarity. 
DISULFID   57    81        By similarity. 
DISULFID   75    86        By similarity. 
Sequence information
Length: 121 AA [This is the length of the unprocessed precursor] Molecular weight: 13533 Da [This is the MW of the unprocessed precursor] CRC64: F5BAA64676954B5E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
NLYQFGKMIF KMTGKSALLS YSDYGCYCGW GGKGKPLDAT DRCCFVHDCC YGRVNGCNPK 

        70         80         90        100        110        120 
LSTYSYSFQN GDIVCGDDNA CLRAVCECDR VAAICFGENL NTYDRKYKDY PSSQCTETEQ 


C
P24293 in FASTA format

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