[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; Mizobuchi K.; Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1093/nar/23.12.2105; PubMed=7610040 [NCBI, ExPASy, EBI, Israel, Japan] Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.; "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."; Nucleic Acids Res. 23:2105-2119(1995).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / MG1655 / ATCC 47076; DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan] Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.; "The complete genome sequence of Escherichia coli K-12."; Science 277:1453-1474(1997).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan] Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."; Mol. Syst. Biol. 2:E1-E5(2006).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128. STRAIN=O2:K1:H+ / MT78; DOI=10.1016/S0923-2508(98)80002-8; PubMed=9766199 [NCBI, ExPASy, EBI, Israel, Japan] Marc D., Arne P., Bree A., Dho-Moulin M.; "Colonization ability and pathogenic properties of a fim- mutant of an avian strain of Escherichia coli."; Res. Microbiol. 149:473-485(1998).
[6]	PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11. STRAIN=K12; DOI=10.1007/BF00330526; PubMed=3083215 [NCBI, ExPASy, EBI, Israel, Japan] Blanco C., Ritzenthaler P., Kolb A.; "The regulatory region of the uxuAB operon in Escherichia coli K12."; Mol. Gen. Genet. 202:112-119(1986).
[7]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10. STRAIN=K12; PubMed=8550444 [NCBI, ExPASy, EBI, Israel, Japan] Klemm P., Tong S., Nielsen H., Conway T.; "The gntP gene of Escherichia coli involved in gluconate uptake."; J. Bacteriol. 178:61-67(1996).

Comments

CATALYTIC ACTIVITY: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H₂O.
PATHWAY: Carbohydrate metabolism; pentose and glucuronate interconversion .
INTERACTION:
P18843:nadE; NbExp=1; IntAct=EBI-1130634, EBI-548960;
INDUCTION: By fructuronate. Its expression is subjected to catabolite repression by glucose.
SIMILARITY: Belongs to the mannonate dehydratase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D13329; BAA02590.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U14003; AAA97218.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC77278.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE78315.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ225176; CAA12424.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X03411; CAA27147.1; ALT_TERM; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X91735; CAA62860.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I57745; I57745.
S56547; S56547.

RefSeq

AP_004814.1; -.
NP_418742.1; -.

3D structure databases

ModBase

P24215.

Protein-protein interaction databases

IntAct

P24215; -.

Enzyme and pathway databases

BioCyc

EcoCyc:MANNONDEHYDRAT-MON; -.
MetaCyc:MANNONDEHYDRAT-MON; -.

Organism-specific databases

EchoBASE

EB1059; -.

EcoGene

EG11066; uxuA.

Ontologies

GO:0008927;	Molecular function: mannonate dehydratase activity (inferred from electronic annotation from HAMAP).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006064;	Biological process: glucuronate catabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

HAMAP

MF_00106; -; 1.
PBIL [Tree]

InterPro

IPR004628; Man_deHydtase.
IPR013022; Xyl_isomerase-like_TIM-brl.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.150; Xyl_isomerase-like_TIM-brl; 1.

Pfam

PF03786; UxuA; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016049; Man_dehyd; 1.

TIGRFAMs

TIGR00695; uxuA; 1.

ProtoNet

P24215.

Genome annotation databases

GeneID

947082; -.

GenomeReviews

U00096_GR; b4322.
AP009048_GR; JW4285.

KEGG

ecj:JW4285; -.
eco:b4322; -.

Phylogenomic databases

HOGENOM

P24215; -.

Genome annotation databases

CMR

P24215; b4322.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Lyase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 394`	`394`	`Mannonate dehydratase.`	`PRO_0000170670`
`VARIANT`	`52 52`	`1`	`I -> V (in strain: MT78).`

Sequence information

Length: 394 AA [This is the length of the unprocessed precursor]

Molecular weight: 44838 Da [This is the MW of the unprocessed precursor]

CRC64: 0716A50BD6436679 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEQTWRWYGP NDPVSLADVR QAGATGVVTA LHHIPNGEVW SVEEILKRKA IIEDAGLVWS 

        70         80         90        100        110        120 
VVESVPIHED IKTHTGNYEQ WIANYQQTLR NLAQCGIRTV CYNFMPVLDW TRTDLEYVLP 

       130        140        150        160        170        180 
DGSKALRFDQ IEFAAFEMHI LKRPGAEADY TEEEIAQAAE RFATMSDEDK ARLTRNIIAG 

       190        200        210        220        230        240 
LPGAEEGYTL DQFRKHLELY KDIDKAKLRE NFAVFLKAII PVAEEVGVRM AVHPDDPPRP 

       250        260        270        280        290        300 
ILGLPRIVST IEDMQWMVDT VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR 

       310        320        330        340        350        360 
STMREDNPKT FHEAAHLNGD VDMYEVVKAI VEEEHRRKAE GKEDLIPMRP DHGHQMLDDL 

       370        380        390 
KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSR

P24215 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools