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UniProtKB/Swiss-Prot entry P23955


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MPPA_NEUCR
Primary accession number P23955
Secondary accession number Q7RVH4
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 80)
Name and origin of the protein
Protein name Mitochondrial-processing peptidase subunit alpha [Precursor]
Synonyms EC 3.4.24.64
Alpha-MPP
Gene name
Name: mpp
ORFNames: NCU06270
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE OF N-TERMINUS.
PubMed=2141023 [NCBI, ExPASy, EBI, Israel, Japan]
Schneider H., Arretz M., Wachter E., Neupert W.;
"Matrix processing peptidase of mitochondria. Structure-function relationships.";
J. Biol. Chem. 265:9881-9887(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J05484; AAA33597.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000025; EAA33638.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A36442; A36442.
RefSeq XP_962874.1; -.
3D structure databases
HSSP P11914; 1HR6. [HSSP ENTRY / PDB]
ModBase P23955.
Protein family/group databases
MEROPS M16.971; -.
Enzyme and pathway databases
BioCyc NCRA-XX3-01:NCRA-XX3-01-010018-MON; -.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004222; Molecular function: metalloendopeptidase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR011237; Pept_M16_core.
IPR011765; Pept_M16_N.
IPR001431; Pept_M16_Zn_BS.
IPR007863; Peptidase_M16_C.
Graphical view of domain structure.
Gene3D G3DSA:3.30.830.10; Pept_M16_core; 2.
Pfam PF00675; Peptidase_M16; 1.
PF05193; Peptidase_M16_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00143; INSULINASE; 1.
ProtoNet P23955.
Genome annotation databases
GeneID 3879027; -.
KEGG ncr:NCU06270; -.
NMPDR fig|5141.1.peg.4058; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Hydrolase; Metalloprotease; Mitochondrion; Protease; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    35  35     Mitochondrion. 
CHAIN   36   577  542     Mitochondrial-processing peptidase subunit alpha. PRO_0000026771
COMPBIAS   259   307  49     Ser-rich. 
CONFLICT   107   107        T -> S (in Ref. 1; AA sequence). 
Sequence information
Length: 577 AA [This is the length of the unprocessed precursor] Molecular weight: 63041 Da [This is the MW of the unprocessed precursor] CRC64: 029491B2FBA01ADB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLNRFRPARL VAQSSRCLPL TRARAGPLPV NNARTLATRA AAVNTKEPTE RDNITTLSNG 

        70         80         90        100        110        120 
VRVASEDLPD AFSGVGVYID AGSRYENDYV RGASHIMDRL AFKSTSTRTA DEMLETVEKL 

       130        140        150        160        170        180 
GGNIQCASSR ESMMYQAATF NKAIPTAVEL MAETIRDPKL TDEELEGQIM TAQYEVNEIW 

       190        200        210        220        230        240 
SKAELILPEL VHMAAFKDNT LGNPLLCPKE RLDYINRDVI QTYRDAFYRP ERLVVAFAGV 

       250        260        270        280        290        300 
PHERAVKLAE KYFGDMKASD APGLSRTGSE TSVDSLVSES SEASSESSSS SSDSSESSGG 

       310        320        330        340        350        360 
LLSKLFSPKA KKATPNPFLT RVPISTEDLT RPAHYTGGFL TLPSQPPPLN PNLPTFTHIQ 

       370        380        390        400        410        420 
LAFEGLAISD DDIYALATLQ TLLGGGGSFS AGGPGKGMYS RLYTNVLNQH GWVESCVAFN 

       430        440        450        460        470        480 
HSYTDSGLFG IAASCYPGRT LPMLQVMCRE LHALTTDHGY SALGELEVSR AKNQLRSSLL 

       490        500        510        520        530        540 
MNLESRMVEL EDLGRQVQVH GRKIPVREMT RRINELTVKD LRRVAKRVVG GMANNAGQGS 

       550        560        570 
GAPTVVLQEA TVQGLKTTEL GWDQIQDTIA QWKLGRR 

P23955 in FASTA format

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