[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=cv. Aura; PubMed=1827067 [NCBI, ExPASy, EBI, Israel, Japan] Bartels D., Engelhardt K., Roncarati R., Schneider K., Rotter M., Salamini F.; "An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein."; EMBO J. 10:1037-1043(1991).
[2]	X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 2-320. DOI=10.1002/prot.21996; PubMed=18300247 [NCBI, ExPASy, EBI, Israel, Japan] Olsen J.G., Pedersen L., Christensen C.L., Olsen O., Henriksen A.; "Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family."; Proteins 71:1572-1581(2008).

Comments

CATALYTIC ACTIVITY: Alditol + NAD(P)⁺ = aldose + NAD(P)H.
INDUCTION: By abscisic acid (ABA) and gibberellic acid (GA).
SIMILARITY: Belongs to the aldo/keto reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X57526; CAA40747.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S15024; S15024.

3D structure databases

PDB

2BGQ; X-ray; 2.50 A; A=2-320.	[ExPASy / RCSB / EBI]
2BGS; X-ray; 1.64 A; A=2-320.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

2BGQ; -.
2BGS; -.

P23901; 13-320.

Organism-specific databases

Gramene

P23901; -.

Ontologies

GO:0004032;	Molecular function: aldehyde reductase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006950;	Biological process: response to stress (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001395; Aldo/ket_red.
Graphical view of domain structure.

PANTHER

PTHR11732; Aldo/ket_red; 1.

Pfam

PF00248; Aldo_ket_red; 1.
Pfam graphical view of domain structure.

PRINTS

PR00069; ALDKETRDTASE.

ProDom

PD000288; Aldo/ket_red; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00798; ALDOKETO_REDUCTASE_1; 1.
PS00062; ALDOKETO_REDUCTASE_2; 1.
PS00063; ALDOKETO_REDUCTASE_3; 1.

ProtoNet

P23901.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; NADP; Oxidoreductase; Stress response.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 320`	`320`	`Aldose reductase.`	`PRO_0000124628`
`NP_BIND`	`215 269`	`55`	`NADP (By similarity).`
`ACT_SITE`	`60 60`		`Proton donor (By similarity).`
`BINDING`	`121 121`		`Substrate (By similarity).`
`SITE`	`88 88`	`1`	`Lowers pKa of active site Tyr (By similarity).`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 35807 Da [This is the MW of the unprocessed precursor]

CRC64: 5AA72C021E9A93C0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASAKATMGQ GEQDHFVLKS GHAMPAVGLG TWRAGSDTAH SVRTAITEAG YRHVDTAAEY 

        70         80         90        100        110        120 
GVEKEVGKGL KAAMEAGIDR KDLFVTSKIW CTNLAPERVR PALENTLKDL QLDYIDLYHI 

       130        140        150        160        170        180 
HWPFRLKDGA HMPPEAGEVL EFDMEGVWKE MENLVKDGLV KDIGVCNYTV TKLNRLLRSA 

       190        200        210        220        230        240 
KIPPAVCQME MHPGWKNDKI FEACKKHGIH VTAYSPLGSS EKNLAHDPVV EKVANKLNKT 

       250        260        270        280        290        300 
PGQVLIKWAL QRGTSVIPKS SKDERIKENI QVFGWEIPEE DFKVLCSIKD EKRVLTGEEL 

       310        320 
FVNKTHGPYR SAADVWDHEN

P23901 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools