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UniProtKB/Swiss-Prot entry P23715


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARGC_BACSU
Primary accession number P23715
Secondary accession numbers O08146 P70953
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on July 15, 1998 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 75)
Name and origin of the protein
Protein name N-acetyl-gamma-glutamyl-phosphate reductase
Synonyms AGPR
EC 1.2.1.38
N-acetyl-glutamate semialdehyde dehydrogenase
NAGSA dehydrogenase
Gene name
Name: argC
OrderedLocusNames: BSU11190
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168 / EMG50;
DOI=10.1093/nar/18.15.4595; PubMed=2117746 [NCBI, ExPASy, EBI, Israel, Japan]
Smith M.C.M., Mountain A., Baumberg S.;
"Nucleotide sequence of the Bacillus subtilis argC gene encoding N-acetylglutamate-gamma-semialdehyde dehydrogenase.";
Nucleic Acids Res. 18:4595-4595(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=8025667 [NCBI, ExPASy, EBI, Israel, Japan]
O'Reilly M., Devine K.M.;
"Sequence and analysis of the citrulline biosynthetic operon argC-F from Bacillus subtilis.";
Microbiology 140:1023-1025(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=9025291 [NCBI, ExPASy, EBI, Israel, Japan]
Levine A., Vannier F., Roche B., Autret S., Mavel D., Seror S.J.;
"A 10.3 kbp segment from nprB to argJ at the 102 degrees region of the Bacillus subtilis chromosome.";
Microbiology 143:175-177(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=9353931 [NCBI, ExPASy, EBI, Israel, Japan]
Medina N., Vannier F., Roche B., Autret S., Levine A., Seror S.J.;
"Sequencing of regions downstream of addA (98 degrees) and citG (289 degrees) in Bacillus subtilis.";
Microbiology 143:3305-3308(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
DOI=10.1016/0378-1119(86)90384-7; PubMed=3106155 [NCBI, ExPASy, EBI, Israel, Japan]
Smith M.C.M., Mountain A., Baumberg S.;
"Sequence analysis of the Bacillus subtilis argC promoter region.";
Gene 49:53-60(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X52834; CAA37016.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z26919; CAA81543.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z79580; CAB01842.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y09476; CAA70638.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99109; CAB12960.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M15420; AAA22248.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I40372; I40372.
RefSeq NP_389001.1; -.
3D structure databases
ModBase P23715.
Enzyme and pathway databases
BioCyc BSUB224308:BSU1120-MON; -.
Organism-specific databases
SubtiList BG10191; argC. [Micado]
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003942; Molecular function: N-acetyl-gamma-glutamyl-phosphate reductase activity (inferred from electronic annotation from HAMAP).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0006526; Biological process: arginine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00150; -; 1.
PBIL [Tree]
InterPro IPR000706; AGPR_act_site.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
ProDom PD003765; AGPR_act_site; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01850; argC; 1.
PROSITE PS01224; ARGC; 1.
ProtoNet P23715.
Genome annotation databases
GeneID 936389; -.
GenomeReviews AL009126_GR; BSU11190.
KEGG bsu:BSU11190; -.
Phylogenomic databases
HOGENOM P23715; -.
Genome annotation databases
CMR P23715; BSU11190.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   346  346     N-acetyl-gamma-glutamyl-phosphate reductase. PRO_0000112385
ACT_SITE   149   149        By similarity. 
CONFLICT   235   235        F -> V (in Ref. 3, 4 and 5). 
CONFLICT   341   341        Missing (in Ref. 1; CAA37016). 
Sequence information
Length: 346 AA [This is the length of the unprocessed precursor] Molecular weight: 38121 Da [This is the MW of the unprocessed precursor] CRC64: 9E22F2AB31B7542B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKIGIVGATG YGGTELVRIL SHHPHAEECI LYSSSGEGNV YSEGYPHLTG LADQQLKPID 

        70         80         90        100        110        120 
MNTIKHEIDI MFLAAPPGVS SELTPKLADA GITVIDLSGD LRIKEPAEYE KWYKRTAAPK 

       130        140        150        160        170        180 
AVIQEAVYGL AELNQLQIQQ AKLIANPGCF PTAVLLGLAP LAQKKLLDES FVIVDAKTGV 

       190        200        210        220        230        240 
SGAGRKASMG THFSELNDNF KIYKVNEHQH TPEIEQALNE WQPGLGPITF SAHLFPMTRG 

       250        260        270        280        290        300 
IMATMYTRLT CDLTADDLHD LYSEFYQDSY FVRVRPKGQY PQTKEVYGSN FCDIAVTLDE 

       310        320        330        340 
RTNRVTIVSV IDNLMKGAAG QAVQNFNLMN GWNEETGLTI ITPIYP 

P23715 in FASTA format

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View entry in raw text format (no links)
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