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UniProtKB/Swiss-Prot entry P23508

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CRCM_HUMAN
Primary accession number P23508
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 1, 1991 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Colorectal mutant cancer protein
Synonym Protein MCC
Gene name
Name: MCC
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1848370 [NCBI, ExPASy, EBI, Israel, Japan]
Kinzler K.W., Nilbert M.C., Vogelstein B., Bryan T.M., Levy D.B., Smith K.J., Preisinger A.C., Hamilton S.R., Hedge P., Markham A., Carlson M., Joslyn G., Groden J., White R., Miki Y., Miyoshi Y., Nishisho I., Nakamura Y.;
"Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.";
Science 251:1366-1370(1991).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 VARIANTS COLORECTAL CANCER LEU-267; LEU-486; L-490; GLN-506 AND VAL-698.
PubMed=1651563 [NCBI, ExPASy, EBI, Israel, Japan]
Nishisho I., Nakamura Y., Miyoshi Y., Miki Y., Ando H., Horii A., Koyama K., Utsunomiya J., Baba S., Hedge P., Markham A., Krush A.J., Petersen G.M., Hamilton S.R., Nilbert M.C., Levy D.B., Bryan T.M., Preisinger A.C., Smith K.J., Su L.-K., Kinzler K.W., Vogelstein B.;
"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.";
Science 253:665-669(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M62397; AAA52069.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009279; AAH09279.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018919; AAH18919.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A38434; A33166.
RefSeq NP_002378.1; -.
UniGene Hs.593171
3D structure databases
ModBase P23508.
Protein-protein interaction databases
DIP DIP:27599N; -.
IntAct P23508; -.
Organism-specific databases
HGNC HGNC:6935; MCC.
GenAtlas MCC.
MIM 159350; gene. [NCBI / EBI]
PharmGKB PA30679; -.
GeneCards P23508.
Gene expression databases
ArrayExpress P23508; -.
CleanEx HS_MCC; -.
GermOnline ENSG00000171444; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004872; Molecular function: receptor activity (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
BLOCKS P23508.
Genome annotation databases
Ensembl ENSG00000171444; Homo sapiens. [Contig view]
GeneID 4163; -.
Phylogenomic databases
HOVERGEN P23508; -.
Other
SOURCE MCC; Homo sapiens.
ProtoNet P23508.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Anti-oncogene; Cell cycle; Disease mutation; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   829  829     Colorectal mutant cancer protein. PRO_0000079333
VARIANT   267   267  1     R -> L (in colorectal cancer). VAR_005141 
VARIANT   486   486  1     P -> L (in colorectal cancer; dbSNP:rs35269015 [NCBI]). VAR_005142 
VARIANT   490   490  1     S -> L (in colorectal cancer). VAR_005143 
VARIANT   506   506  1     R -> Q (in colorectal cancer). VAR_005144 
VARIANT   698   698  1     A -> V (in colorectal cancer). VAR_005145 
VARIANT   751   751  1     S -> C (in dbSNP:rs17313892 [NCBI]). VAR_033753 
Sequence information
Length: 829 AA [This is the length of the unprocessed precursor] Molecular weight: 93055 Da [This is the MW of the unprocessed precursor] CRC64: 5D45225FD91CA18F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ QTERERDLLE KKLAKAQCEQ 

        70         80         90        100        110        120 
SHLMREHEDV QERTTLRYEE RITELHSVIA ELNKKIDRLQ GTTIREEDEY SELRSELSQS 

       130        140        150        160        170        180 
QHEVNEDSRS MDQDQTSVSI PENQSTMVTA DMDNCSDLNS ELQRVLTGLE NVVCGRKKSS 

       190        200        210        220        230        240 
CSLSVAEVDR HIEQLTTASE HCDLAIKTVE EIEGVLGRDL YPNLAEERSR WEKELAGLRE 

       250        260        270        280        290        300 
ENESLTAMLC SKEEELNRTK ATMNAIREER DRLRRRVREL QTRLQSVQAT GPSSPGRLTS 

       310        320        330        340        350        360 
TNRPINPSTG ELSTSSSSND IPIAKIAERV KLSKTRSESS SSDRPVLGSE ISSIGVSSSV 

       370        380        390        400        410        420 
AEHLAHSLQD CSNIQEIFQT LYSHGSAISE SKIREFEVET ERLNSRIEHL KSQNDLLTIT 

       430        440        450        460        470        480 
LEECKSNAER MSMLVGKYES NATALRLALQ YSEQCIEAYE LLLALAESEQ SLILGQFRAA 

       490        500        510        520        530        540 
GVGSSPGDQS GDENITQMLK RAHDCRKTAE NAAKALLMKL DGSCGGAFAV AGCSVQPWES 

       550        560        570        580        590        600 
LSSNSHTSTT SSTASSCDTE FTKEDEQRLK DYIQQLKNDR AAVKLTMLEL ESIHIDPLSY 

       610        620        630        640        650        660 
DVKPRGDSQR LDLENAVLMQ ELMAMKEEMA ELKAQLYLLE KEKKALELKL STREAQEQAY 

       670        680        690        700        710        720 
LVHIEHLKSE VEEQKEQRMR SLSSTSSGSK DKPGKECADA ASPALSLAEL RTTCSENELA 

       730        740        750        760        770        780 
AEFTNAIRRE KKLKARVQEL VSALERLTKS SEIRHQQSAE FVNDLKRANS NLVAAYEKAK 

       790        800        810        820 
KKHQNKLKKL ESQMMAMVER HETQVRMLKQ RIALLEEENS RPHTNETSL
P23508 in FASTA format

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