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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
DOI=10.1016/0378-1119(92)90191-Q; PubMed=1511895 [NCBI, ExPASy, EBI, Israel, Japan]
Romanik E.A.,
Ladino C.A.,
Killoy L.C.,
D'Ardenne S.C.,
O'Connor C.M.;
"Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase.";
Gene 118:217-222(1992).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6;
TISSUE=Brain, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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PROTEIN SEQUENCE OF 82-98, AND MASS SPECTROMETRY.
TISSUE=Hippocampus;
Lubec G.,
Klug S.;
Submitted (MAR-2007) to UniProtKB.
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 186-227 (ISOFORM 2).
DOI=10.1006/abbi.1994.1341; PubMed=8037467 [NCBI, ExPASy, EBI, Israel, Japan]
Galus A.,
Lagos A.,
Romanik E.A.,
O'Connor C.M.;
"Structural analysis of transcripts for the protein L-isoaspartyl methyltransferase reveals multiple transcription initiation sites and a distinct pattern of expression in mouse testis: identification of a 5'-flanking sequence with promoter activity.";
Arch. Biochem. Biophys. 312:524-533(1994).
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[5]
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SUBSTRATES.
DOI=10.1074/jbc.M605421200; PubMed=16923807 [NCBI, ExPASy, EBI, Israel, Japan]
Vigneswara V.,
Lowenson J.D.,
Powell C.D.,
Thakur M.,
Bailey K.,
Clarke S.,
Ray D.E.,
Carter W.G.;
"Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme.";
J. Biol. Chem. 281:32619-32629(2006).
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- FUNCTION: Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Cytoplasm.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | P23506-2 |
| Features which should be applied to build the isoform sequence: VSP_004717. |
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- SIMILARITY: Belongs to the L-isoaspartyl/D-aspartyl protein methyltransferase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 227 AA [This is the length of the unprocessed precursor] |
Molecular weight: 24634 Da [This is the MW of the unprocessed precursor] |
CRC64: 954E2491A9DA9249 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKSNPYMDSP QSIGFQATIS
70 80 90 100 110 120
APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GNSGKVIGID HIKELVDDSI
130 140 150 160 170 180
TNVKKDDPML LSSGRVRLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI
190 200 210 220
LPVGPAGGNQ MLEQYDKLQD GSVKMKPLMG VIYVPLTDKE KQWSRWK
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P23506 in FASTA format |
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