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UniProtKB/Swiss-Prot entry P23466

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYAA_SACKL
Primary accession number P23466
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Adenylate cyclase
Synonyms EC 4.6.1.1
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene name
Name: CYR1
From
Saccharomyces kluyveri (Yeast) (Saccharomyces silvestris) [TaxID: 4934] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(91)90551-L; PubMed=1864503 [NCBI, ExPASy, EBI, Israel, Japan]
Young D., O'Neill K., Broek D., Wigler M.;
"The adenylyl cyclase-encoding gene from Saccharomyces kluyveri.";
Gene 102:129-132(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X56042; CAA39513.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JQ1145; OYBYK.
3D structure databases
HSSP Q99280; 1FX4. [HSSP ENTRY / PDB]
ModBase P23466.
Ontologies
GO
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
IPR001611; LRR.
IPR003591; LRR_sub-typ.
IPR001932; PP2C-related.
IPR014045; PP2C_N.
IPR000159; Ras-assoc.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 1.
G3DSA:3.60.40.10; PP2C-related; 1.
Pfam PF00211; Guanylate_cyc; 1.
PF00560; LRR_1; 13.
PF00481; PP2C; 1.
PF00788; RA; 1.
Pfam graphical view of domain structure.
PRINTS PR00019; LEURICHRPT.
SMART SM00044; CYCc; 1.
SM00369; LRR_TYP; 2.
SM00332; PP2Cc; 1.
SM00314; RA; 1.
SMART graphical view of domain structure.
PROSITE PS50125; GUANYLATE_CYCLASE_2; 1.
PS50200; RA; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P23466.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Leucine-rich repeat; Lyase; Magnesium; Metal-binding; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1839  1839     Adenylate cyclase. PRO_0000195732
DOMAIN   494    574  81     Ras-associating. 
REPEAT   632    655  24     LRR 1. 
REPEAT   659    679  21     LRR 2. 
REPEAT   680    702  23     LRR 3. 
REPEAT   703    724  22     LRR 4. 
REPEAT   726    748  23     LRR 5. 
REPEAT   749    771  23     LRR 6. 
REPEAT   773    793  21     LRR 7. 
REPEAT   794    818  25     LRR 8. 
REPEAT   820    833  14     LRR 9. 
REPEAT   834    857  24     LRR 10. 
REPEAT   859    879  21     LRR 11. 
REPEAT   880    903  24     LRR 12. 
REPEAT   905    926  22     LRR 13. 
REPEAT   927    949  23     LRR 14. 
REPEAT   951    974  24     LRR 15. 
REPEAT   1004   1025  22     LRR 16. 
REPEAT   1026   1048  23     LRR 17. 
REPEAT   1050   1072  23     LRR 18. 
REPEAT   1074   1096  23     LRR 19. 
REPEAT   1101   1124  24     LRR 20. 
REPEAT   1135   1160  26     LRR 21. 
DOMAIN   1185   1440  256     PP2C-like. 
DOMAIN   1483   1620  138     Guanylate cyclase. 
METAL   1488   1488        Magnesium (By similarity). 
METAL   1531   1531        Magnesium (By similarity). 
Sequence information
Length: 1839 AA [This is the length of the unprocessed precursor] Molecular weight: 206896 Da [This is the MW of the unprocessed precursor] CRC64: 86A69BCB1F2733CB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSPTDAERV NMRREKHPQI EETFEEHVHN AMPKFKKHYA LGITTHTNDE DDDPRDHRQR 

        70         80         90        100        110        120 
GIHNPNFIHS PNDPRPPLSQ PIKPRFSVHG TASNASVFSH GDIAPVRKTS RAGSLFKRLA 

       130        140        150        160        170        180 
GKKSTTSLLG TEHQQRQQQQ SSNSLVPAAG LRRKMSTFIH GGSGSQSNES RGTRSSIFFP 

       190        200        210        220        230        240 
STSNSRRGSA TSTMTSGSRS SHPPDTPPIT SQQQEQQYDQ QRQQRPETRE QEQKPPTLSD 

       250        260        270        280        290        300 
MPIVSRSPSF FMLDTDLNNL SDITNIISAT PKNTESDEVR STGANKTLKY PKPPLSSHKS 

       310        320        330        340        350        360 
TSASDLSHHK AQWTAPESWD IEEDANKLLA TKRKAKHHHH YHHPQHPRPP HRKHYSNFSK 

       370        380        390        400        410        420 
PIEDKAVVEK EQEPPEKCPQ PISTDSNDAQ GLEIAKPIDE SSGIQHSAST QSVSSFSSGA 

       430        440        450        460        470        480 
TGASGATGKQ IGGDQETEST ISTVGEDEEV TNLRSIDSEQ TDDTSFSKFD EEYDKAEYQL 

       490        500        510        520        530        540 
EKYYNDFSDV DLNRRYAIRI FNIDDTFTTL SCTPNTTLQD MMPQLKRKFN VGQGSYQVSL 

       550        560        570        580        590        600 
KVGKLSKILR PTAKPILIQR RLLLLNGYLK SDPLHIMGIE DLSFIFSFVF HPVATSHLNY 

       610        620        630        640        650        660 
EQEQRLSRGD FVHVDLRNMD LTTPPIILYQ HTSDIESLDV SNNANIFLPL DFIESAIKLS 

       670        680        690        700        710        720 
SLRMVNIRAS KFPANVTDAY KLVSLDLERN FIKKVPDSIF KLNNLTIVNL QCNNLERLPP 

       730        740        750        760        770        780 
GFSKLKNLQL LDISSNKFVN YPEVINSCTN LLQIDLSYNK IHSLPVSINQ LVKLAKMNLF 

       790        800        810        820        830        840 
NNRLTSVGDL SQMKNLRTLN LRCNRVTSIE CHAPNLQNLF LTDNRISTFD DDLTRLRTLE 

       850        860        870        880        890        900 
LQQNPITSMV CGGNYMANMT SLSLNKAKLS SFSAELLSKL PRLEKLELNE NNLTQLPPEI 

       910        920        930        940        950        960 
NKLTRLIYLS VARNKLESIP DEISDLRSLK SLDLHSNNLR MLMNNLEDLE LTSLNVSSNL 

       970        980        990       1000       1010       1020 
LTGFHGSPAK FFASPSPKLA KSLLFLSVAD NNLTDSIWPL VNTFQNLKTL NLSYNNFVEI 

      1030       1040       1050       1060       1070       1080 
SDLKLQNLTE LYLSGNNFTS LPGEAVQHLR SLKVLMLNGN KLLSLPAELS QLSRLSVLDV 

      1090       1100       1110       1120       1130       1140 
GSNQLKYNIS NYHYDWNWRN NKDLKYLNFS GNKRFEIKSA LDPEGKNDLS DLGILKQLRV 

      1150       1160       1170       1180       1190       1200 
LGLMDVTLKT SKVPDESVSI RLRTTASMIN GMRYGVADTL GQSDSVCSRD VTFERFRGRE 

      1210       1220       1230       1240       1250       1260 
DECLICLYDG KNENASSGHK ISKIIRDIYD KILIRLLEKY GEESDGIKRA LRYSFLQLNK 

      1270       1280       1290       1300       1310       1320 
EINGMLVSVE DGNTDSGLTS ADLLSGSSAT VVYLKGKKIY TANIGDTMAV LSKNNGDFVT 

      1330       1340       1350       1360       1370       1380 
LTKLHVPAER EEYERIRTSG GYVNNQKLDG VSEVSRAVGF FDLLPHIHAS PDISETVLSY 

      1390       1400       1410       1420       1430       1440 
SDEMLIIATH KLWEYLDYET VCDISRENKS QPMSAAEKMK DYAISYGCSD NITILCVSLD 

      1450       1460       1470       1480       1490       1500 
KSVNQQSQFT LNREDLISRK NTFEDTVLRR LQPEIAPPTG NVAIVFTDIK NSTFLWELFP 

      1510       1520       1530       1540       1550       1560 
DAMRAAIKTH NDIMRRQLRI YGGYEVKTEG DAFMVAFPTP TSALVWCLSV QLKLLEAEWP 

      1570       1580       1590       1600       1610       1620 
EEITSIQDGC LITDNSGTKV YLGLSVRMGV HWGCPVPEID LVTQRMDYLG PVVNKAARVS 

      1630       1640       1650       1660       1670       1680 
GVADGGQITL SSDFCSEFKK IMKFHKRVVE NQEPLKEVYG EDFIGEVLER EIHMLENVGW 

      1690       1700       1710       1720       1730       1740 
VFKDLGEQKL KGLETKEFIT IAYPKTLASR HDLATKNQNS SVLNDDLLFQ LRTISNKLEN 

      1750       1760       1770       1780       1790       1800 
ILSSINGGLI ESETPGNSSI YMTFDKNTKD AVITKSTESD WISFLDHLVT RVESTVAILQ 

      1810       1820       1830 
LRQKLQGGLE LYTSSDSTMH KSVFELLDEI LKIQTDQKQ
P23466 in FASTA format

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View entry in raw text format (no links)
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