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UniProtKB/Swiss-Prot entry P23458


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JAK1_HUMAN
Primary accession number P23458
Secondary accession number Q59GQ2
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 25, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 92)
Name and origin of the protein
Protein name Tyrosine-protein kinase JAK1
Synonyms EC 2.7.10.2
Janus kinase 1
JAK-1
Gene name
Name: JAK1
Synonyms: JAK1A, JAK1B
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1848670 [NCBI, ExPASy, EBI, Israel, Japan]
Wilks A.F., Harpur A.G., Kurban R.R., Ralph S.J., Zuercher G., Ziemiecki A.;
"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.";
Mol. Cell. Biol. 11:2057-2065(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1005-1062.
PubMed=8247543 [NCBI, ExPASy, EBI, Israel, Japan]
Lee S.-T., Strunk K.M., Spritz R.A.;
"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.";
Oncogene 8:3403-3410(1993).
[7]
INTERACTION WITH SHB.
DOI=10.1016/S0006-291X(02)02016-8; PubMed=12200137 [NCBI, ExPASy, EBI, Israel, Japan]
Lindholm C.K.;
"IL-2 receptor signaling through the Shb adapter protein in T and NK cells.";
Biochem. Biophys. Res. Commun. 296:929-936(2002).
[8]
INTERACTION WITH IL31RA.
DOI=10.1074/jbc.M401122200; PubMed=15194700 [NCBI, ExPASy, EBI, Israel, Japan]
Dreuw A., Radtke S., Pflanz S., Lippok B.E., Heinrich P.C., Hermanns H.M.;
"Characterization of the signaling capacities of the novel gp130-like cytokine receptor.";
J. Biol. Chem. 279:36112-36120(2004).
[9]
INTERACTION WITH JAKMIP1.
DOI=10.1074/jbc.M401915200; PubMed=15277531 [NCBI, ExPASy, EBI, Israel, Japan]
Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S.;
"Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules.";
J. Biol. Chem. 279:43168-43177(2004).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1034 AND TYR-1035, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
[11]
VARIANT [LARGE SCALE ANALYSIS] LYS-973.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M64174; AAA36527.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209057; BAD92294.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC093427; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471059; EAX06547.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC132729; AAI32730.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A39577; A39577.
UniGene Hs.207538
3D structure databases
HSSP P08069; 1JQH. [HSSP ENTRY / PDB]
ModBase P23458.
Protein-protein interaction databases
DIP DIP:133N; -.
PTM databases
PhosphoSite P23458; -.
Organism-specific databases
HGNC HGNC:6190; JAK1.
GenAtlas JAK1.
HPA CAB013088; -.
MIM 147795; gene. [NCBI / EBI]
PharmGKB PA29988; -.
GeneCards P23458.
Gene expression databases
ArrayExpress P23458; -.
CleanEx HS_JAK1; -.
GermOnline ENSG00000162434; Homo sapiens.
Ontologies
GO
GO:0005856; Cellular component: cytoskeleton (inferred from electronic annotation from InterPro).
GO:0012505; Cellular component: endomembrane system (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004718; Molecular function: Janus kinase activity (inferred from electronic annotation from InterPro).
GO:0004715; Molecular function: non-membrane spanning protein tyrosine kinase activity (inferred from electronic annotation from EC).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000299; Band_4.1_N.
IPR009127; JAK.
IPR009128; JAK1.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016251; TyrPK_Jak.
Graphical view of domain structure.
Pfam PF07714; Pkinase_Tyr; 2.
Pfam graphical view of domain structure.
PIRSF PIRSF000636; TyrPK_Jak; 1.
PRINTS PR01823; JANUSKINASE.
PR01824; JANUSKINASE1.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 2.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
SMART graphical view of domain structure.
PROSITE PS00660; FERM_1; FALSE_NEG.
PS00661; FERM_2; FALSE_NEG.
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P23458.
Genome annotation databases
Ensembl ENSG00000162434; Homo sapiens. [Contig view]
KEGG hsa:3716; -.
Phylogenomic databases
HOVERGEN P23458; -.
Other
SOURCE JAK1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Repeat; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1154  1154     Tyrosine-protein kinase JAK1. PRO_0000088108
DOMAIN   34    420  387     FERM. 
DOMAIN   439    544  106     SH2. 
DOMAIN   583    855  273     Protein kinase 1. 
DOMAIN   875   1153  279     Protein kinase 2. 
NP_BIND   881    889  9     ATP (By similarity). 
ACT_SITE   1003   1003        Proton acceptor (By similarity). 
BINDING   908    908        ATP (By similarity). 
MOD_RES   1034   1034        Phosphotyrosine; by autocatalysis (By similarity). 
MOD_RES   1035   1035        Phosphotyrosine. 
VARIANT   973    973  1     N -> K. VAR_041715 
CONFLICT   350    350        H -> D (in Ref. 1; M64174). 
CONFLICT   368    368        Y -> F (in Ref. 1; M64174). 
CONFLICT   898    898        Missing (in Ref. 1; M64174). 
Sequence information
Length: 1154 AA [This is the length of the unprocessed precursor] Molecular weight: 133277 Da [This is the MW of the unprocessed precursor] CRC64: A2C4BE27851ACABB [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL GSGEYTAEEL 

        70         80         90        100        110        120 
CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK MSLRLHYRMR FYFTNWHGTN 

       130        140        150        160        170        180 
DNEQSVWRHS PKKQKNGYEK KKIPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 

       190        200        210        220        230        240 
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 

       250        260        270        280        290        300 
NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 

       310        320        330        340        350        360 
WFHSNDGGNV LYYEVMVTGN LGIQWRHKPN VVSVEKEKNK LKRKKLENKH KKDEEKNKIR 

       370        380        390        400        410        420 
EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 

       430        440        450        460        470        480 
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 

       490        500        510        520        530        540 
CFEKSEQVQG AQKQFKNFQI EVQKGRYSLH GSDRSFPSLG DLMSHLKKQI LRTDNISFML 

       550        560        570        580        590        600 
KRCCQPKPRE ISNLLVATKK AQEWQPVYPM SQLSFDRILK KDLVQGEHLG RGTRTHIYSG 

       610        620        630        640        650        660 
TLMDYKDDEG TSEEKKIKVI LKVLDPSHRD ISLAFFEAAS MMRQVSHKHI VYLYGVCVRD 

       670        680        690        700        710        720 
VENIMVEEFV EGGPLDLFMH RKSDVLTTPW KFKVAKQLAS ALSYLEDKDL VHGNVCTKNL 

       730        740        750        760        770        780 
LLAREGIDSE CGPFIKLSDP GIPITVLSRQ ECIERIPWIA PECVEDSKNL SVAADKWSFG 

       790        800        810        820        830        840 
TTLWEICYNG EIPLKDKTLI EKERFYESRC RPVTPSCKEL ADLMTRCMNY DPNQRPFFRA 

       850        860        870        880        890        900 
IMRDINKLEE QNPDIVSEKK PATEVDPTHF EKRFLKRIRD LGEGHFGKVE LCRYDPEGDN 

       910        920        930        940        950        960 
TGEQVAVKSL KPESGGNHIA DLKKEIEILR NLYHENIVKY KGICTEDGGN GIKLIMEFLP 

       970        980        990       1000       1010       1020 
SGSLKEYLPK NKNKINLKQQ LKYAVQICKG MDYLGSRQYV HRDLAARNVL VESEHQVKIG 

      1030       1040       1050       1060       1070       1080 
DFGLTKAIET DKEYYTVKDD RDSPVFWYAP ECLMQSKFYI ASDVWSFGVT LHELLTYCDS 

      1090       1100       1110       1120       1130       1140 
DSSPMALFLK MIGPTHGQMT VTRLVNTLKE GKRLPCPPNC PDEVYQLMRK CWEFQPSNRT 

      1150 
SFQNLIEGFE ALLK 

P23458 in FASTA format

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