[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2165490 [NCBI, ExPASy, EBI, Israel, Japan] Lipkin V.M., Khramtsov N.V., Vasilevskaya I.A., Atabekova N.V., Muradov K.G., Gubanov V.V., Li T., Johnston J.P., Volpp K.J., Applebury M.L.; "Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family."; J. Biol. Chem. 265:12955-12959(1990).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=2161230 [NCBI, ExPASy, EBI, Israel, Japan] Lipkin V.M., Gubanov V.V., Khramtsov N.V., Vasilevskaya I.A., Atabekova N.V., Muradov K.G., Shuvaeva T.M., Surina E.A., Zagranichny V.E., Li T.; "Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of beta-subunit and nucleotide sequence of corresponding cDNA."; Bioorg. Khim. 16:118-120(1990).

Comments

FUNCTION: This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
CATALYTIC ACTIVITY: Guanosine 3',5'-cyclic phosphate + H₂O = guanosine 5'-phosphate.
SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
SIMILARITY: Contains 2 GAF domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J05553; AAA30440.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X57146; CAA40436.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

A36617; A36617.

NP_776843.1; -.

3D structure databases

ModBase

P23439.

Ontologies

GO:0016020;	Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0047555;	Molecular function: 3',5'-cyclic-GMP phosphodiesterase activity (inferred from electronic annotation from EC).
GO:0050896;	Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from InterPro).
GO:0007601;	Biological process: visual perception (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003018; GAF.
IPR003607; Met-dep_phosphohydro_HD.
IPR002073; PDEase.
Graphical view of domain structure.

Pfam

PF01590; GAF; 2.
PF00233; PDEase_I; 1.
Pfam graphical view of domain structure.

PRINTS

PR00387; PDIESTERASE1.

SMART

SM00065; GAF; 2.
SM00471; HDc; 1.
SMART graphical view of domain structure.

PROSITE

PS00126; PDEASE_I; 1.

Genome annotation databases

Ensembl

ENSBTAG00000017480; Bos taurus. [Contig view]

GeneID

281974; -.

KEGG

bta:281974; -.

Phylogenomic databases

HOVERGEN

P23439; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

cGMP; Hydrolase; Lipoprotein; Membrane; Prenylation; Repeat; Sensory transduction; Vision.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 850`	`850`	`Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta.`	`PRO_0000023344`
`PROPEP`	`851 853`	`3`	`Removed in mature form (By similarity).`	`PRO_0000023345`
`DOMAIN`	`71 220`	`150`	`GAF 1.`
`DOMAIN`	`252 429`	`178`	`GAF 2.`
`LIPID`	`850 850`		`S-geranylgeranyl cysteine (By similarity).`
`CONFLICT`	`483 484`		`DE -> EQ (in Ref. 2).`

Sequence information

Length: 853 AA [This is the length of the unprocessed precursor]

Molecular weight: 98331 Da [This is the MW of the unprocessed precursor]

CRC64: C4B3F22CFFE7F2FB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLSEGQVHR FLDQNPGFAD QYFGRKLSPE DVANACEDGC PEGCTSFREL CQVEESAALF 

        70         80         90        100        110        120 
ELVQDMQENV NMERVVFKIL RRLCSILHAD RCSLFMYRQR NGVAELATRL FSVQPDSVLE 

       130        140        150        160        170        180 
DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN VQDVMECPHF SSFADELTDY VTRNILATPI 

       190        200        210        220        230        240 
MNGKDVVAVI MAVNKLDGPC FTSEDEDVFL KYLNFGTLNL KIYHLSYLHN CETRRGQVLL 

       250        260        270        280        290        300 
WSANKVFEEL TDIERQFHKA FYTVRAYLNC DRYSVGLLDM TKEKEFFDVW PVLMGEAQAY 

       310        320        330        340        350        360 
SGPRTPDGRE ILFYKVIDYI LHGKEDIKVI PSPPADHWAL ASGLPTYVAE SGFICNIMNA 

       370        380        390        400        410        420 
PADEMFNFQE GPLDDSGWIV KNVLSMPIVN KKEEIVGVAT FYNRKDGKPF DEQDEVLMES 

       430        440        450        460        470        480 
LTQFLGWSVL NTDTYDKMNK LENRKDIAQD MVLYHVRCDR EEIQLILPTR ERLGKEPADC 

       490        500        510        520        530        540 
EEDELGKILK EVLPGPAKFD IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL 

       550        560        570        580        590        600 
VRFLFSVSKG YRRITYHNWR HGFNVAQTMF TLLMTGKLKS YYTDLEAFAM VTAGLCHDID 

       610        620        630        640        650        660 
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR RQHEHVIHLM 

       670        680        690        700        710        720 
DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DRKSWVEYLS LETTRKEIVM AMMMTACDLS 

       730        740        750        760        770        780 
AITKPWEVQS KVALLVAAEF WEQGDLERTV LDQQPIPMMD RNKAAELPKL QVGFIDFVCT 

       790        800        810        820        830        840 
FVYKEFSRFH EEILPMFDRL QNNRKEWKAL ADEYEAKVKA LEEDQKKETT AKKVGTEICN 

       850 
GGPAPRSSTC RIL

P23439 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools