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- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport.
- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
- DOMAIN: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
- SIMILARITY: Contains 2 PTS EIIB type-2 domains.
- SIMILARITY: Contains 1 PTS EIIC type-2 domain.
- CAUTION: Only one of the two EIIB domains may be active since the first domain lacks the active site and is probably unable to bind and transfer a phosphate group.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 578 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58576 Da [This is the MW of the unprocessed precursor] |
CRC64: 87793E5AAA608E4E [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSKIVAVTAG AKGVAHTHLA AEALSATAQA LGHQIRVERH SAEGVEAPLQ GAEIAAADVV
70 80 90 100 110 120
LIAADLRIED VRFVTKPVYR TSTARAVTQT AAVLAEALAL TGEETPQMTT DTGQRPLRVV
130 140 150 160 170 180
AITSCPTGIA HTFMAADALK KTAAARGWEI AVETQGSVGS QNALSAAQIQ AADLVVIAAD
190 200 210 220 230 240
THVDDSRFAG KKVYKTSVGA AVKGAAKVLD AALAEGVVLG TNLADTVDAL KAQRAATRSG
250 260 270 280 290 300
PYMHLLTGVS YMLPLVVAGG LLIALSFVFG IKAFEVEGTL PAALMAIGGG AAFKLMVPVL
310 320 330 340 350 360
AGFIAYSIAD RPGLTPGLIG GMLAVNLNAG FLGGIVAGFL AGYVARWLRD AIKLPRTLEG
370 380 390 400 410 420
LKPVLILPLL STAITGLIMV YVVGTPVAAI LAAMTAFLQG LGTTNAVVLG LILGGMMAVD
430 440 450 460 470 480
MGGPINKAAY TFAVGLLTSS TYAPMAAVMA AGMTPPLGLA LATLVAKNRF TAEEREAGGA
490 500 510 520 530 540
AAVLGLSFIT EGAIPFAAKD PARVIPSIIV GSAITGALSM ALGCLLVAPH GGIFVLAIPH
550 560 570
AVTNLGLYAL SIVVGTLVTT GLLIALKKPI PAEERARS
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P23387 in FASTA format |
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