[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Brain;
DOI=10.1038/349760a0; PubMed=1847995 [NCBI, ExPASy, EBI, Israel, Japan]
Masu M.,
Tanabe Y.,
Tsuchida K.,
Shigemoto R.,
Nakanishi S.;
"Sequence and expression of a metabotropic glutamate receptor.";
Nature 349:760-765(1991).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1656524 [NCBI, ExPASy, EBI, Israel, Japan]
Houamed K.M.,
Kuijper J.L.,
Gilbert T.L.,
Haldeman B.A.,
O'Hara P.J.,
Mulvihill E.R.,
Almers W.,
Hagen F.S.;
"Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.";
Science 252:1318-1321(1991).
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[3]
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ALTERNATIVE SPLICING (ISOFORM 1B).
TISSUE=Brain;
DOI=10.1016/0896-6273(92)90118-W; PubMed=1309649 [NCBI, ExPASy, EBI, Israel, Japan]
Tanabe Y.,
Masu M.,
Ishii T.,
Shigemoto R.,
Nakanishi S.;
"A family of metabotropic glutamate receptors.";
Neuron 8:169-179(1992).
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[4]
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ALTERNATIVE SPLICING (ISOFORM 1C).
TISSUE=Brain;
PubMed=1438218 [NCBI, ExPASy, EBI, Israel, Japan]
Pin J.-P.,
Waeber C.,
Prezeau L.,
Bockaert J.,
Heinemann S.F.;
"Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.";
Proc. Natl. Acad. Sci. U.S.A. 89:10331-10335(1992).
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[5]
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INTERACTION WITH SIAH1.
PubMed=10469171 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa K.,
Nash S.R.,
Nishimune A.,
Neki A.,
Kaneko S.,
Nakanishi S.;
"Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors.";
Genes Cells 4:381-390(1999).
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[6]
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INTERACTION WITH GRASP.
PubMed=11850456 [NCBI, ExPASy, EBI, Israel, Japan]
Kitano J.,
Kimura K.,
Yamazaki Y.,
Soda T.,
Shigemoto R.,
Nakajima Y.,
Nakanishi S.;
"Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.";
J. Neurosci. 22:1280-1289(2002).
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- FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
- SUBUNIT: Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3 (By similarity). Interacts with SIAH1 and GRASP.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
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| Name | 1B |
| Isoform ID | P23385-2 |
| Note: C-terminally truncated forms of isoform 1A. |
| Features which should be applied to build the isoform sequence: VSP_002026, VSP_002027. |
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| Name | 1C |
| Isoform ID | P23385-3 |
| Note: C-terminally truncated forms of isoform 1A. |
| Features which should be applied to build the isoform sequence: VSP_002028, VSP_002029. |
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- TISSUE SPECIFICITY: Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb.
- MISCELLANEOUS: Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate; inhibited by 2-amino-3-phosphonopropionate.
- SIMILARITY: Belongs to the G-protein coupled receptor 3 family [view classification].
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