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UniProtKB/Swiss-Prot entry P23371

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PAP1_VACCV
Primary accession number P23371
Secondary accession number Q80HX2
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on December 7, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Poly(A) polymerase catalytic subunit
Synonyms EC 2.7.7.19
Poly(A) polymerase large subunit
PAP-L
VP55
Gene name
Name: PAPL
OrderedLocusNames: VACWR057
ORFNames: E1L
From
Vaccinia virus (strain Western Reserve / WR) (VACV) [TaxID: 10254] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Gershon P.D., Jones E.V., Moss B., Ahn B.-Y.;
Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J., Wohlhueter R.;
"Sequencing of the coding region of Vaccinia-WR to an average 9-fold redundancy and an error rate of 0.16/10kb.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[3]
 FUNCTION.
DOI=10.1016/0092-8674(91)90048-4; PubMed=1670500 [NCBI, ExPASy, EBI, Israel, Japan]
Gershon P.D., Ahn B.-Y., Garfield M., Moss B.;
"Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus.";
Cell 66:1269-1278(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M36339; AAB59821.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY243312; AAO89336.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_232939.1; -.
3D structure databases
PDB
2GA9; X-ray; 2.30 A; D=11-479.[ExPASy / RCSB / EBI]
2GAF; X-ray; 2.40 A; D=11-479.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2GA9; -.
2GAF; -.
SMR P23371; 12-479.
ModBase P23371.
Ontologies
GO
GO:0004652; Molecular function: polynucleotide adenylyltransferase activity (inferred from electronic annotation from InterPro).
GO:0006397; Biological process: mRNA processing (inferred from electronic annotation from InterPro).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004976; PolyA_pol_cat_poxviral.
Graphical view of domain structure.
Pfam PF03296; Pox_polyA_pol; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF015693; VAC-48L_nuct; 1.
BLOCKS P23371.
ProtoNet P23371.
Genome annotation databases
GeneID 3707514; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; mRNA processing; Transcription; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   479  479     Poly(A) polymerase catalytic subunit. PRO_0000099107
ACT_SITE   202   202        By similarity. 
ACT_SITE   204   204        By similarity. 
CONFLICT   10    10        L -> F (in Ref. 1; AAB59821). 
CONFLICT   68    68        N -> D (in Ref. 1; AAB59821). 
CONFLICT   199   199        R -> L (in Ref. 1; AAB59821). 
Sequence information
Length: 479 AA [This is the length of the unprocessed precursor] Molecular weight: 55531 Da [This is the MW of the unprocessed precursor] CRC64: 2E76F2BB1A246D5F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNRNPDQNTL PNITLKIIET YLGRVPSVNE YHMLKLQARN IQKITVFNKD IFVSLVKKNK 

        70         80         90        100        110        120 
KRFFSDVNTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL QSVLVTTYTD ILGVLTIKAP 

       130        140        150        160        170        180 
NVISSKISYN VTSMEELARD MLNSMNVAVI DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN 

       190        200        210        220        230        240 
KSCICYGSYS LYLINPNIRY GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY 

       250        260        270        280        290        300 
MVIKDENDNH IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 

       310        320        330        340        350        360 
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD YFSFKKCLVY 

       370        380        390        400        410        420 
LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF SNTILLSDKG KVHEISARGL 

       430        440        450        460        470 
CAHILLYQML TSGEYKQCLS DLLNSMMNRD KIPIYSHTER DKKPGRHGFI NIEKDIIVF
P23371 in FASTA format

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