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UniProtKB/Swiss-Prot entry P23362


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CCKN_MACFA
Primary accession number P23362
Secondary accession number Q4R5N2
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on November 1, 1991 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name Cholecystokinin [Precursor]
Synonym CCK
Contains Cholecystokinin-58
     (CCK58)
Cholecystokinin-58 desnonopeptide
     ((1-49)-CCK58)
Cholecystokinin-39
     (CCK39)
Cholecystokinin-33
     (CCK33)
Cholecystokinin-25
     (CCK25)
Cholecystokinin-18
     (CCK18)
Cholecystokinin-12
     (CCK12)
Cholecystokinin-8
     (CCK8)
Cholecystokinin-7
     (CCK7)
Cholecystokinin-5
     (CCK5)
Gene name
Name: CCK
ORFNames: QccE-12659
From
Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2174979 [NCBI, ExPASy, EBI, Israel, Japan]
Bernal J., Godbout M., Hasel K.W., Travis G.H., Sutcliffe J.G.;
"Patterns of cerebral cortex mRNA expression.";
J. Neurosci. Res. 27:153-158(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
International consortium for macaque cDNA sequencing and analysis;
"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications.";
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
  • SUBUNIT: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity).
  • SUBCELLULAR LOCATION: Secreted.
  • PTM: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
  • SIMILARITY: Belongs to the gastrin/cholecystokinin family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M60458; AAA36837.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB169511; BAE01593.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A48318; A48318.
3D structure databases
ModBase P23362.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from InterPro).
GO:0005179; Molecular function: hormone activity (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR015499; CCK.
IPR001651; Gastrin.
IPR013152; Gastrin_CCK_CS.
Graphical view of domain structure.
PANTHER PTHR10786; CCK; 1.
Pfam PF00918; Gastrin; 1.
Pfam graphical view of domain structure.
SMART SM00029; GASTRIN; 1.
SMART graphical view of domain structure.
PROSITE PS00259; GASTRIN; 1.
ProtoNet P23362.
Phylogenomic databases
HOVERGEN P23362; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Cleavage on pair of basic residues; Hormone; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     By similarity. 
CHAIN   21   115  95     Cholecystokinin. PRO_0000010544
PROPEP   21    44  24      PRO_0000010545
PEPTIDE   46   103  58     Cholecystokinin-58 (By similarity). PRO_0000010546
PEPTIDE   46    94  49     Cholecystokinin-58 desnonopeptide (By similarity). PRO_0000306309
PEPTIDE   65   103  39     Cholecystokinin-39 (By similarity). PRO_0000010547
PEPTIDE   71   103  33     Cholecystokinin-33 (By similarity). PRO_0000010548
PEPTIDE   79   103  25     Cholecystokinin-25 (By similarity). PRO_0000306310
PEPTIDE   86   103  18     Cholecystokinin-18 (By similarity). PRO_0000306311
PEPTIDE   92   103  12     Cholecystokinin-12 (By similarity). PRO_0000010549
PEPTIDE   96   103  8     Cholecystokinin-8 (By similarity). PRO_0000010550
PEPTIDE   97   103  7     Cholecystokinin-7 (By similarity). PRO_0000306312
PEPTIDE   99   103  5     Cholecystokinin-5 (By similarity). PRO_0000306313
PROPEP   107   115  9      PRO_0000010551
MOD_RES   97    97        Sulfotyrosine (By similarity). 
MOD_RES   103   103        Phenylalanine amide. 
MOD_RES   111   111        Sulfotyrosine (By similarity). 
MOD_RES   113   113        Sulfotyrosine (By similarity). 
Sequence information
Length: 115 AA [This is the length of the unprocessed precursor] Molecular weight: 12665 Da [This is the MW of the unprocessed precursor] CRC64: C151B73646E95019 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNSGVSLCVL MAVLAAGALT QPVPPAEPAG SGLQRAEEAP RRQLRAVQRT DGESRAHLGA 

        70         80         90        100        110 
LLARYIQQAR KAPSGRMSII KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS 

P23362 in FASTA format

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