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UniProtKB/Swiss-Prot entry P23280


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CAH6_HUMAN
Primary accession number P23280
Secondary accession numbers Q96QX8 Q9UF03
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on October 17, 2006 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 79)
Name and origin of the protein
Protein name Carbonic anhydrase 6 [Precursor]
Synonyms EC 4.2.1.1
Carbonic anhydrase VI
CA-VI
Carbonate dehydratase VI
Secreted carbonic anhydrase
Salivary carbonic anhydrase
Gene name
Name: CA6
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-90.
DOI=10.1021/bi00216a035; PubMed=1899030 [NCBI, ExPASy, EBI, Israel, Japan]
Aldred P., Fu P., Barrett G., Penschow J.D., Wright R., Coghlan J.P., Fernley R.T.;
"Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry.";
Biochemistry 30:569-575(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-90.
Grubb D.J.;
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M57892; AAA51892.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128418; AAF22565.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128411; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128412; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128413; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128414; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128415; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128416; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF128417; AAF22565.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139415; CAC42429.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A37917; CRHU6.
RefSeq NP_001206.2; -.
UniGene Hs.100322
3D structure databases
HSSP O43570; 1JD0. [HSSP ENTRY / PDB]
ModBase P23280.
Organism-specific databases
H-InvDB HIX0020003; -.
HIX0028508; -.
HGNC HGNC:1380; CA6.
GenAtlas CA6.
MIM 114780; gene. [NCBI / EBI]
PharmGKB PA24381; -.
GeneCards P23280.
Gene expression databases
ArrayExpress P23280; -.
CleanEx HS_CA6; -.
GermOnline ENSG00000131686; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004089; Molecular function: carbonate dehydratase activity (traceable author statement from ProtInc).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001148; Euk_COanhd.
Graphical view of domain structure.
Gene3D G3DSA:3.10.200.10; Euk_COanhd; 1.
PANTHER PTHR18952; Euk_COanhd; 1.
Pfam PF00194; Carb_anhydrase; 1.
Pfam graphical view of domain structure.
ProDom PD000865; Euk_COanhd; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00162; ALPHA_CA_1; 1.
PS51144; ALPHA_CA_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P23280.
ProtoNet P23280.
Genome annotation databases
Ensembl ENSG00000131686; Homo sapiens. [Contig view]
GeneID 765; -.
KEGG hsa:765; -.
Phylogenomic databases
HOVERGEN P23280; -.
Other
NextBio 3092; -.
SOURCE CA6; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Lyase; Metal-binding; Polymorphism; Secreted; Signal; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   308  291     Carbonic anhydrase 6. PRO_0000004241
METAL   111   111        Zinc; catalytic (By similarity). 
METAL   113   113        Zinc; catalytic (By similarity). 
METAL   138   138        Zinc; catalytic (By similarity). 
CARBOHYD   67    67        N-linked (GlcNAc...) (Potential). 
CARBOHYD   256   256        N-linked (GlcNAc...) (Potential). 
DISULFID   42   224        Potential. 
VARIANT   37    37  1     Q -> L (in dbSNP:rs34265054 [NCBI]). VAR_033712 
VARIANT   55    55  1     T -> M (in dbSNP:rs2274327 [NCBI]). VAR_028268 
VARIANT   68    68  1     M -> L (in dbSNP:rs2274328 [NCBI]). VAR_028269 
VARIANT   70    70  1     G -> A (in dbSNP:rs2274329 [NCBI]). VAR_028270 
VARIANT   90    90  1     S -> G (in dbSNP:rs2274333 [NCBI]). VAR_028271 
CONFLICT   103   103        T -> I (in Ref. 1; AAA51892). 
CONFLICT   148   148        S -> T (in Ref. 1; AAA51892 and 2; AAF22565). 
CONFLICT   270   270        N -> K (in Ref. 1; AAA51892 and 2; AAF22565). 
Sequence information
Length: 308 AA [This is the length of the unprocessed precursor] Molecular weight: 35367 Da [This is the MW of the unprocessed precursor] CRC64: 6EBFF15085E7112D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI NLQRTKVRYN 

        70         80         90        100        110        120 
PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA DGTVYIAQQM HFHWGGASSE 

       130        140        150        160        170        180 
ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD IAQDAPDGLA VLAAFVEVKN YPENTYYSNF 

       190        200        210        220        230        240 
ISHLANIKYP GQRTTLTGLD VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS 

       250        260        270        280        290        300 
RTQVWKLENS LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL 


DYLRRALN 

P23280 in FASTA format

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