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UniProtKB/Swiss-Prot entry P23247

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHAS_VIBCH
Primary accession number P23247
Secondary accession numbers O34226 Q9KQ93
Integrated into Swiss-Prot on November 1, 1991
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Aspartate-semialdehyde dehydrogenase
Synonyms ASA dehydrogenase
ASADH
EC 1.2.1.11
Gene name
Name: asd
OrderedLocusNames: VC_2107
From
Vibrio cholerae [TaxID: 666] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CDV 101;
Avest A.R., Frits R.M.;
Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=El Tor C7258 / Serotype O1;
Fando R., Benitez J.;
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 39315 / El Tor Inaba N16961 / Serotype O1;
DOI=10.1038/35020000; PubMed=10952301 [NCBI, ExPASy, EBI, Israel, Japan]
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.";
Nature 406:477-483(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X55363; CAA39048.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y15281; CAA75569.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE003852; AAF95253.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B82118; B82118.
S14523; S14523.
RefSeq NP_231739.1; -.
3D structure databases
PDB
2QZ9; X-ray; 2.20 A; A/B/C=2-337.[ExPASy / RCSB / EBI]
2R00; X-ray; 2.03 A; A/B/C=2-337.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2QZ9; -.
2R00; -.
ModBase P23247.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0019877; Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000319; Asp-semialdehyde_DHase_CS.
IPR012080; Asp_semialdehyde_DHase.
IPR005986; Asp_semialdehyde_DHase_bac.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000148; ASA_dh; 1.
TIGRFAMs TIGR01296; asd_B; 1.
PROSITE PS01103; ASD; 1.
ProtoNet P23247.
Genome annotation databases
GeneID 2613363; -.
GenomeReviews AE003852_GR; VC_2107.
KEGG vch:VC2107; -.
TIGR VC_2107; -.
Phylogenomic databases
HOGENOM P23247; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   337  337     Aspartate-semialdehyde dehydrogenase. PRO_0000141394
ACT_SITE   132   132        Acyl-thioester intermediate (By similarity). 
VARIANT   40    40  1     E -> D (in strain: C7258). 
CONFLICT   188   189        NT -> QA (in Ref. 1; CAA39048). 
STRAND   5    11  7      
HELIX   15    26  12      
STRAND   31    38  8      
TURN   40    44  5      
STRAND   46    49  4      
STRAND   52    58  7      
HELIX   59    61  3      
HELIX   64    66  3      
STRAND   68    72  5      
HELIX   76    88  13      
STRAND   92    95  4      
TURN   99   102  4      
TURN   111   113  3      
HELIX   115   123  9      
STRAND   125   128  4      
HELIX   132   148  17      
STRAND   150   163  14      
TURN   204   206  3      
HELIX   212   224  13      
STRAND   231   241  11      
STRAND   243   255  13      
HELIX   259   268  10      
STRAND   272   274  3      
HELIX   281   283  3      
STRAND   289   291  3      
STRAND   293   301  9      
STRAND   304   316  13      
HELIX   317   336  20      
Sequence information
Length: 337 AA [This is the length of the unprocessed precursor] Molecular weight: 37375 Da [This is the MW of the unprocessed precursor] CRC64: 143D7E55593308FD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQQFNVAIF GATGAVGETM LEVLQEREFP VDELFLLASE RSEGKTYRFN GKTVRVQNVE 

        70         80         90        100        110        120 
EFDWSQVHIA LFSAGGELSA KWAPIAAEAG VVVIDNTSHF RYDYDIPLVV PEVNPEAIAE 

       130        140        150        160        170        180 
FRNRNIIANP NCSTIQMLVA LKPIYDAVGI ERINVTTYQS VSGAGKAGID ELAGQTAKLL 

       190        200        210        220        230        240 
NGYPAETNTF SQQIAFNCIP QIDQFMDNGY TKEEMKMVWE TQKIFNDPSI MVNPTCVRVP 

       250        260        270        280        290        300 
VFYGHAEAVH VETRAPIDAE QVMDMLEQTD GIELFRGADF PTQVRDAGGK DHVLVGRVRN 

       310        320        330 
DISHHSGINL WVVADNVRKG AATNAVQIAE LLVRDYF
P23247 in FASTA format

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